Vitamin A deficiency and the expression of retinoic acid receptors during early cardiogenesis in quail embryo

1996 ◽  
Vol 205 (5-6) ◽  
pp. 260-271 ◽  
Author(s):  
I. Kostetskii ◽  
K. K. Linask ◽  
M. H. Zile
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Retinoic Acid Receptors ◽  
Quail Embryo

Vitamin A and Retinoic Acid in Cognition and Cognitive Disease

2020 ◽  
Vol 40 (1) ◽  
pp. 247-272 ◽  
Author(s):  
Marta U. Wołoszynowska-Fraser ◽  
Azita Kouchmeshky ◽  
Peter McCaffery
Keyword(s):  
Retinoic Acid ◽  
Synaptic Plasticity ◽  
Vitamin A ◽  
Cognitive Decline ◽  
Developmental Disorders ◽  
Vitamin A Deficiency ◽  
Retinoic Acid Receptors ◽  
Controlled Synthesis ◽  
History Of ◽  
The Brain

The history of vitamin A goes back over one hundred years, but our realization of its importance for the brain and cognition is much more recent. The brain is more efficient than other target tissues at converting vitamin A to retinoic acid (RA), which activates retinoic acid receptors (RARs). RARs regulate transcription, but their function in the cytoplasm to control nongenomic actions is also crucial. Controlled synthesis of RA is essential for regulating synaptic plasticity in regions of the brain involved in learning and memory, such as the hippocampus. Vitamin A deficiency results in a deterioration of these functions, and failure of RA signaling is perhaps associated with normal cognitive decline with age as well as with Alzheimer's disease. Further, several psychiatric and developmental disorders that disrupt cognition are also linked with vitamin A and point to their possible treatment with vitamin A or RA.

Effect of marginal vitamin A deficiency during pregnancy on retinoic acid receptors and NMDA receptor expression in the offspring of rats

2010 ◽  
Vol 34 (8) ◽  
pp. S75-S75
Author(s):  
Xuan Zhang ◽  
Ting‑yu Li ◽  
Ke Chen ◽  
Jie Chen ◽  
You‑xue Liu ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Nmda Receptor ◽  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Receptor Expression ◽  
Retinoic Acid Receptors

Complex regulation of TGF beta expression by retinoic acid in the vitamin A-deficient rat

Development ◽  
1991 ◽  
Vol 111 (4) ◽  
pp. 1081-1086 ◽  
Author(s):  
A.B. Glick ◽  
B.K. McCune ◽  
N. Abdulkarem ◽  
K.C. Flanders ◽  
J.A. Lumadue ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Alveolar Epithelium ◽  
Tgf Beta ◽  
Basal Expression ◽  
Beta 2 ◽  
Complex Regulation ◽  
First Time

We report the results of a histochemical study, using polyclonal antipeptide antibodies to the different TGF beta isoforms, which demonstrates that retinoic acid regulates the expression of TGF beta 2 in the vitamin A-deficient rat. Basal expression of TGF beta 2 diminished under conditions of vitamin A deficiency. Treatment with retinoic acid caused a rapid and transient induction of TGF beta 2 and TGF beta 3 in the epidermis, tracheobronchial and alveolar epithelium, and intestinal mucosa. Induction of TGF beta 1 expression was also observed in the epidermis. In contrast to these epithelia, expression of the three TGF beta isoforms increased in vaginal epithelium during vitamin A deficiency, and decreased following systemic administration of retinoic acid. Our results show for the first time the widespread regulation of TGF beta expression by retinoic acid in vivo, and suggest a possible mechanism by which retinoics regulate the functions of both normal and pre-neoplastic epithelia.

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