Improvement of epidermal differentiation and barrier function in reconstructed human skin after grafting onto athymic nude mice

1994 ◽  
Vol 286 (2) ◽  
pp. 107-114 ◽  
Author(s):  
I. Higounenc ◽  
M. D�marchez ◽  
M. R�gnier ◽  
R. Schmidt ◽  
M. Ponec ◽  
...  
Keyword(s):  
Human Skin ◽  
Nude Mice ◽  
Barrier Function ◽  
Epidermal Differentiation ◽  
Athymic Nude Mice ◽  
Reconstructed Human Skin ◽  
Grafting Onto

Lipid Composition and Barrier Function of Human Skin after Grafting onto Athymic Nude Mice

1994 ◽  
Vol 7 (4) ◽  
pp. 167-175 ◽  
Author(s):  
Isabelle Higounenc ◽  
Ferry Spies ◽  
Harry Boddé ◽  
Hans Schaefer ◽  
Michel Demarchez ◽  
...  
Keyword(s):  
Human Skin ◽  
Nude Mice ◽  
Lipid Composition ◽  
Barrier Function ◽  
Athymic Nude Mice ◽  
Grafting Onto

Hyperpigmentation of human skin grafted on to athymic nude mice: immunohistochemical study

1996 ◽  
Vol 135 (3) ◽  
pp. 412-418 ◽  
Author(s):  
K. MATSUMOTO ◽  
E. ROBB ◽  
G. WARDEN ◽  
J. NORDLUND
Keyword(s):  
Human Skin ◽  
Nude Mice ◽  
Immunohistochemical Study ◽  
Athymic Nude Mice

Wound healing using human skin transplanted onto athymic nude mice: A comparison of “dry” and “moist” wound healing

1991 ◽  
Vol 32 (1-2) ◽  
pp. 122-124 ◽  
Author(s):  
G. R. Elliott ◽  
A. H. Hammer ◽  
M. J. Fasbender ◽  
E. Claassen
Keyword(s):  
Wound Healing ◽  
Human Skin ◽  
Nude Mice ◽  
Athymic Nude Mice

Epithelial Differentiation of Human Skin Equivalents After Grafting Onto Nude Mice

1988 ◽  
Vol 91 (2) ◽  
pp. 136-141 ◽  
Author(s):  
Ana Ramirez Bosca ◽  
Estelle Tinois ◽  
Michel Faure ◽  
Jean Kanitakis ◽  
Pascale Roche ◽  
...  
Keyword(s):  
Human Skin ◽  
Nude Mice ◽  
Epithelial Differentiation ◽  
Skin Equivalents ◽  
Grafting Onto

Ultraviolet B induces hyperproliferation and modification of epidermal differentiation in normal human skin grafted on to nude mice

2004 ◽  
Vol 150 (4) ◽  
pp. 658-667 ◽  
Author(s):  
S. Del Bino ◽  
C. Vioux ◽  
P. Rossio-Pasquier ◽  
A. Jomard ◽  
M. Demarchez ◽  
...  
Keyword(s):  
Human Skin ◽  
Nude Mice ◽  
Ultraviolet B ◽  
Epidermal Differentiation ◽  
Normal Human Skin ◽  
Normal Human

scholarly journals Ultrastructural and Molecular Analysis of Ribose-Induced Glycated Reconstructed Human Skin

2018 ◽  
Vol 19 (11) ◽  
pp. 3521 ◽  
Author(s):  
Roberta Balansin Rigon ◽  
Sabine Kaessmeyer ◽  
Christopher Wolff ◽  
Christian Hausmann ◽  
Nan Zhang ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Human Skin ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Aging ◽  
Skin Barrier Function ◽  
Stratum Granulosum ◽  
End Products ◽  
Cell Layers ◽  
Reconstructed Human Skin

Aging depicts one of the major challenges in pharmacology owing to its complexity and heterogeneity. Thereby, advanced glycated end-products modify extracellular matrix proteins, but the consequences on the skin barrier function remain heavily understudied. Herein, we utilized transmission electron microscopy for the ultrastructural analysis of ribose-induced glycated reconstructed human skin (RHS). Molecular and functional insights substantiated the ultrastructural characterization and proved the relevance of glycated RHS beyond skin aging. In particular, electron microscopy mapped the accumulation and altered spatial orientation of fibrils and filaments in the dermal compartment of glycated RHS. Moreover, the epidermal basement membrane appeared thicker in glycated than in non-glycated RHS, but electron microscopy identified longitudinal clusters of the finest collagen fibrils instead of real thickening. The stratum granulosum contained more cell layers, the morphology of keratohyalin granules decidedly differed, and the stratum corneum lipid order increased in ribose-induced glycated RHS, while the skin barrier function was almost not affected. In conclusion, dermal advanced glycated end-products markedly changed the epidermal morphology, underlining the importance of matrix–cell interactions. The phenotype of ribose-induced glycated RHS emulated aged skin in the dermis, while the two to three times increased thickness of the stratum granulosum resembled poorer cornification.

Pathology Produced by Sulfur Mustard in Human Skin Grafts on Athymic Nude Mice. I. Gross and Light Microscopic Changes

1984 ◽  
Vol 3 (4) ◽  
pp. 371-391 ◽  
Author(s):  
Bruno Papimeisier ◽  
Clark L. Gross ◽  
John P. Petrali ◽  
Clifford J. Hixson
Keyword(s):  
Human Skin ◽  
Nude Mice ◽  
Sulfur Mustard ◽  
Skin Grafts ◽  
Athymic Nude Mice
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