Ultraviolet B induces hyperproliferation and modification of epidermal differentiation in normal human skin grafted on to nude mice

2004 ◽  
Vol 150 (4) ◽  
pp. 658-667 ◽  
Author(s):  
S. Del Bino ◽  
C. Vioux ◽  
P. Rossio-Pasquier ◽  
A. Jomard ◽  
M. Demarchez ◽  
...  
Keyword(s):  
Human Skin ◽  
Nude Mice ◽  
Ultraviolet B ◽  
Epidermal Differentiation ◽  
Normal Human Skin ◽  
Normal Human

scholarly journals Characterization of Epidermal Lipoxygenase Expression in Normal Human Skin and Tissue-Engineered Skin Substitutes

2018 ◽  
Vol 66 (11) ◽  
pp. 813-824 ◽  
Author(s):  
Carolyne Simard-Bisson ◽  
Lorraine Andrée Parent ◽  
Véronique J. Moulin ◽  
Bernard Fruteau de Laclos
Keyword(s):  
Human Skin ◽  
Expression Profiles ◽  
Skin Barrier ◽  
Epidermal Differentiation ◽  
Skin Barrier Function ◽  
Skin Substitutes ◽  
Differentiation Markers ◽  
Normal Human Skin ◽  
Normal Human ◽  
Engineered Skin Substitutes

Lipoxygenases (LOXs) are enzymes likely to be involved in corneocyte lipid envelope formation and skin barrier function. In humans, mutations in epidermis-type lipoxygenase 3 ( eLOX-3) and 12R–lipoxygenase ( 12R-LOX) genes are associated with autosomal recessive congenital ichthyosis (ARCI), whereas deletion of these genes in mice causes epidermal defects. LOXs also represent a matter of interest in psoriasis as well as in cancer research. However, their expression as well as the exact role of these enzymes in normal human skin have not been fully described. Our goal was to characterize the expression of epidermal LOXs in both normal human skin and Tissue-Engineered Skin Substitutes (TESS) and to consider TESS as a potential model for LOX functional studies. Staining for epidermal differentiation markers and LOXs was performed, in parallel, on normal human skin and TESS. Our results showed similar expression profiles in TESS when compared with native skin for e-LOX3, 12R-LOX, 12S-lipoxygenase (12S-LOX), and 15-lipoxygenase 2 (15-LOX-2) but not for 15-lipoxygenase 1 (15-LOX-1). Because of their appropriate epidermal differentiation and LOX expression, TESS represent an alternative model for future studies on LOX function.

Neutrophils infiltrating ultraviolet B-irradiated normal human skin display high IL-10 expression

2004 ◽  
Vol 296 (7) ◽  
pp. 339-342 ◽  
Author(s):  
Gamze Piskin ◽  
Jan D. Bos ◽  
Marcel B. M. Teunissen
Keyword(s):  
Human Skin ◽  
Ultraviolet B ◽  
Normal Human Skin ◽  
Normal Human

The immunohistochemical effects of a single challenge with an intermediate dose of ultraviolet B on normal human skin

1996 ◽  
Vol 288 (9) ◽  
pp. 510-516 ◽  
Author(s):  
C. J. M. van der Vleuten ◽  
E. J. A. Kroot ◽  
E. M. G. J. de Jong ◽  
P. C. M. van de Kerkhof
Keyword(s):  
Human Skin ◽  
Ultraviolet B ◽  
Normal Human Skin ◽  
Normal Human ◽  
Intermediate Dose

Histological and ultrastructural effects of cyclosporin A on normal human skin xenografted on to nude mice

1990 ◽  
Vol 416 (6) ◽  
pp. 505-511 ◽  
Author(s):  
Jean Kanitakis ◽  
Ana Ramirez-Bosca ◽  
Marek Haftek ◽  
Jean Thivolet
Keyword(s):  
Cyclosporin A ◽  
Human Skin ◽  
Nude Mice ◽  
Normal Human Skin ◽  
Normal Human
Sign in / Sign up

Export Citation Format

Share Document