Serum acetylcholine receptor antibodies in diagnosis and therapy monitoring of myasthenia gravis

1980 ◽  
Vol 301 (2) ◽  
pp. 127-128 ◽  
Author(s):  
K. Heininger ◽  
A. Fateh-Moghadam ◽  
K. V. Toyka ◽  
U. A. Besinger ◽  
J. Witthöft
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Therapy Monitoring ◽  
Diagnosis And Therapy ◽  
Receptor Antibodies

Therapeutic Immunoadsorption of Acetylcholine Receptor Antibodies in Myasthenia Gravis

1988 ◽  
Vol 540 (1 Advances in N) ◽  
pp. 554-556 ◽  
Author(s):  
TAKESHI SATO ◽  
YASUNORI ISHIGAKI ◽  
TADATOSHI KOMIYA ◽  
HIROSHI TSUDA
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Receptor Antibodies

Subunit specificity of the acetylcholine receptor antibodies in double seropositive myasthenia gravis

2021 ◽  
Author(s):  
Vasiliki Zouvelou ◽  
Maria Michail ◽  
Maria Belimezi ◽  
Paraskevi Zisimopoulou
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Receptor Antibodies

scholarly journals Myasthenia gravis in children: analysis of 18 patients

2001 ◽  
Vol 59 (3B) ◽  
pp. 681-685 ◽  
Author(s):  
Maria da Penha A. Morita ◽  
Alberto A. Gabbai ◽  
Acary S.B. Oliveira ◽  
Audrey S. Penn
Keyword(s):  
Myasthenia Gravis ◽  
Intravenous Immunoglobulin ◽  
Acetylcholine Receptor ◽  
Nerve Stimulation ◽  
Chest Ct ◽  
Clinical Severity ◽  
Myasthenic Crisis ◽  
Repetitive Nerve Stimulation ◽  
Follicular Hyperplasia ◽  
Receptor Antibodies

Myasthenia gravis (MG) in childhood is rare comprising 10 to 20 % of all myasthenic patients. We studied 18 patients with MG whose first symptoms started from 1 to 12 years of age, followed at the Department of Neurology of the UNIFESP-EPM, from January 1983 to August 1997. There were 10 girls and 8 boys (1.2:1). Eleven patients (61%) presented moderate or severe generalized disease and 4 (22%) had at least one myasthenic crisis. EMG with supramaximal repetitive nerve stimulation was diagnostic in 8 (47%) out of 17 patients, and chest CT was normal in 14 patients. Seropositivity to acetylcholine receptor antibodies was found in 81.6% (9 out of 11 tested) and the levels had no relation to clinical severity. Nine out of 16 patients (56%) worsened with pyridostigmine alone and were treated with prednisone. Four out of those nine continued worsening despite steroids and were subjected to thymectomy (all showed thymic lymphoid follicular hyperplasia). Three patients (75%) improved markedly after thymectomy and one (25%) worsened, eventually getting better with intravenous immunoglobulin and oral azathioprine. MG treatment, using all resources available, has to be individualized for each child.

Acetylcholine Receptor Antibodies in Penicillamine-lnduced Myasthenia Gravis

JAMA ◽  
1981 ◽  
Vol 246 (17) ◽  
pp. 1901
Author(s):  
Tomas S. Bocanegra
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Receptor Antibodies

Binding properties and subclass distribution of anti-acetylcholine receptor antibodies in myasthenia gravis

1981 ◽  
Vol 1 (1) ◽  
pp. 125-135 ◽  
Author(s):  
Ann Kari Lefvert ◽  
Sylvia Cuénoud ◽  
Bernard W. Fulpius
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Binding Properties ◽  
Receptor Antibodies ◽  
Anti Acetylcholine

Serum Acetylcholine Receptor Antibodies Before the Clinical Onset of Myasthenia Gravis

2018 ◽  
Vol 5 (2) ◽  
pp. 261-264 ◽  
Author(s):  
Ellen Strijbos ◽  
Jan J.G.M. Verschuuren ◽  
Jan B.M. Kuks
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Clinical Onset ◽  
Receptor Antibodies

Immunoenzymometric assay and radioimmunoassay measure different populations of antibody against human acetylcholine receptor.

1985 ◽  
Vol 31 (6) ◽  
pp. 835-840 ◽  
Author(s):  
C L Hinman ◽  
C M Kellogg ◽  
R M Ernstoff ◽  
H C Rauch ◽  
R A Hudson
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Nicotinic Acetylcholine ◽  
Receptor Antibody ◽  
Low Concentrations ◽  
Sandwich Type ◽  
Different Populations ◽  
Receptor Antibodies

Abstract We used a "sandwich"-type immunoenzymometric assay (IEMA) and a radioimmunoassay (RIA) to measure antibody against the human nicotinic acetylcholine receptor in serum from individuals with myasthenia gravis, with markedly different results for certain specimens, as measured by the two techniques. In some cases, antibody concentrations were high by RIA but low by IEMA; in others, the reverse was found. Such differences persisted through 30 months after thymectomy. An investigation of potential causes of this disparity suggests that high IEMA measurements reflect specific anti-receptor antibody and are not artifactual. The IEMA is recommended as an adjunct to the RIA because some patients with myasthenia gravis who have low concentrations of anti-receptor antibodies as measured by RIA have significantly above-normal concentrations of anti-receptor antibodies as measured by IEMA.

Anti-acetylcholine receptor antibodies in neonatal myasthenia gravis: Heterogeneity and pathogenic significance

1991 ◽  
Vol 4 (2) ◽  
pp. 185-195 ◽  
Author(s):  
Bruno Eymard ◽  
Béatrice Vernet-der Garabedian ◽  
Sonia Berrih-Aknin ◽  
Claude Pannier ◽  
Jean-François Bach ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Receptor Antibodies ◽  
Anti Acetylcholine

Molecular analysis of anti-acetylcholine receptor antibodies in experimental autoimmune myasthenia gravis (EAMG)

1994 ◽  
Vol 4 (5-6) ◽  
pp. S38
Author(s):  
Y. Graus ◽  
F. Meng ◽  
R. Aarts ◽  
A. Vincent ◽  
P. van Breda Vriesman ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Molecular Analysis ◽  
Experimental Autoimmune Myasthenia Gravis ◽  
Autoimmune Myasthenia ◽  
Receptor Antibodies ◽  
Experimental Autoimmune ◽  
Anti Acetylcholine
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