Degeneration activity of the pineal gland after sympathetic denervation

1982 ◽  
Vol 321 (4) ◽  
pp. 298-301 ◽  
Author(s):  
M. A. Luchelli-Fortis ◽  
F. J. E. Stefano ◽  
C. J. Perec
Keyword(s):  
Pineal Gland ◽  
Sympathetic Denervation ◽  
Degeneration Activity

DEGENERATION ACTIVITY in the PINEAL GLAND AFTER SYMPATHETIC DENERVATION

Abstracts ◽  
1978 ◽  
pp. 816
Author(s):  
F.J.E. Stefano ◽  
M.A. Luchelli-Fortis
Keyword(s):  
Pineal Gland ◽  
Sympathetic Denervation ◽  
Degeneration Activity

Maternal Coordination of the Daily Rhythm of Malate Dehydrogenase Activity in Testes from Young Rats: Effect of Maternal Sympathetic Denervation of the Pineal Gland and Administration of Melatonin

1995 ◽  
Vol 12 (1) ◽  
pp. 8-18 ◽  
Author(s):  
N. T. Vermouth ◽  
C. S. Carriazo ◽  
R. V. Gallará ◽  
A. R. Carpentieri ◽  
S. L. Bellavía
Keyword(s):  
Pineal Gland ◽  
Dehydrogenase Activity ◽  
Malate Dehydrogenase ◽  
Daily Rhythm ◽  
Sympathetic Denervation ◽  
Young Rats

Effect of sympathetic denervation of the pineal gland on maternal co-ordination of the circadian rhythm of α-amylase in parotid gland from young rats

1993 ◽  
Vol 38 (12) ◽  
pp. 1121-1125 ◽  
Author(s):  
S.L. Bellavía ◽  
E.G. Sanz ◽  
R.V. Gallará ◽  
A. Carpentieri ◽  
N.T. Vermouth
Keyword(s):  
Circadian Rhythm ◽  
Parotid Gland ◽  
Pineal Gland ◽  
Sympathetic Denervation ◽  
Young Rats

Pineal gland

AccessScience ◽  
2015 ◽  
Keyword(s):  
Pineal Gland

Monosodium glutamate administration early in life alters pineal melatonin nocturnal profile in adulthood

2021 ◽  
Vol 4 (1) ◽  
pp. 99-114
Author(s):  
Janaína B Garcia ◽  
Fernanda G Do Amaral ◽  
Daniela C Buonfiglio ◽  
Rafaela FA Vendrame ◽  
Patrícia L Alves ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Pineal Gland ◽  
Serum Insulin ◽  
Monosodium Glutamate ◽  
Female Rats ◽  
Pineal Melatonin ◽  
Melatonin Synthesis ◽  
Male And Female Rats ◽  
Melatonin Production

The pineal gland synthesizes melatonin exclusively at night, which gives melatonin the characteristic of a temporal synchronizer of the physiological systems. Melatonin is a regulator of insulin activities centrally and also peripherally and its synthesis is reduced in diabetes.  Since monosodium glutamate (MSG) is often used to induce the type 2 diabetic and metabolic syndrome in animal models, the purpose of this work is to evaluate the potential effects of MSG given to neonates on the pineal melatonin synthesis in different aged male and female rats. Wistar rats were subcutaneously injected with MSG (4mg/g/day) or saline solution (0.9%) from the second to eighth post-natal day. The circadian profiles both melatonin levels and AANAT activity were monitored at different ages. Body weight, naso-anal length, adipose tissues weight, GTT, ITT and serum insulin levels were also evaluated. Typical obesity with the neonatal MSG treatment was observed, indicated by a great increase in adipose depots without a concurrent increase in body weight. MSG treatment did not cause hyperglycemia or glucose intolerance, but induced insulin resistance. An increase of melatonin synthesis at ZT 15 with phase advance was observed in in some animals. The AANAT activity was positively parallel to the melatonin circadian profile. It seems that MSG causes hypothalamic obesity which may increase AANAT activity and melatonin production in pineal gland. These effects were not temporally correlated with insulin resistance and hyperinsulinemia indicating the hypothalamic lesions, particularly in arcuate nucleus induced by MSG in early age, as the principal cause of the increase in melatonin production.

Low melatonin as a contributor to SARS-CoV-2 disease

2020 ◽  
Vol 3 (4) ◽  
pp. 558-576
Author(s):  
Seithikurippu R Pandi-Perumal ◽  
Daniel P Cardinali ◽  
Russel J Reiter ◽  
Gregory M Brown
Keyword(s):  
Reactive Oxygen Species ◽  
Oxidative Phosphorylation ◽  
Pineal Gland ◽  
Oxygen Species ◽  
Cytokine Storm ◽  
Major Site ◽  
Immune Modulator ◽  
Inflammatory Agent ◽  
Site Of Action ◽  
Extrapineal Melatonin

That the pineal gland is a source of melatonin is widely known; however, by comparison, few know of the much larger pool of extrapineal melatonin. That pool is widely distributed in all animals, including those that do not have a pineal gland, e.g., insects.  Extrapineal melatonin is not released into the blood but is used locally to function as an antioxidant, anti-inflammatory agent, etc. A major site of action of peripherally-produced melatonin is the mitochondria where it neutralizes reactive oxygen species (ROS) that are generated during oxidative phosphorylation. Its role also includes major actions as an immune modulator reducing overreactions to foreign agents while simultaneously boosting immune processes. During a pandemic such as coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, melatonin is capable of suppressing the damage inflicted by the cytokine storm. The implications of melatonin in susceptibility and treatment of COVID-19 disease are discussed. 

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