Studies on the role of Na+, K+ and Cl? ion permeabilities in K+-induced release of 3H-noradrenaline from rat brain slices and synaptosomes and in its presynaptic ?-adrenergic modulation

1981 ◽  
Vol 317 (2) ◽  
pp. 103-109 ◽  
Author(s):  
Johan Wemer ◽  
Anton N. M. Schoffelmeer ◽  
Arie H. Mulder
Keyword(s):  
Rat Brain ◽  
Brain Slices ◽  
Adrenergic Modulation

scholarly journals The role of Ca2+ in the protoveratrine-induced release of γ-aminobutyrate from rat brain slices

1980 ◽  
Vol 190 (2) ◽  
pp. 333-339 ◽  
Author(s):  
M C W Minchin
Keyword(s):  
Cerebral Cortex ◽  
Rat Brain ◽  
Dose Response ◽  
Transmitter Release ◽  
Response Curve ◽  
Brain Slices ◽  
Veratrum Alkaloids ◽  
Similar Dose ◽  
22Na Uptake

1. Protoveratrine A increased the release of gamma-amino[3H]butyrate from small slices of rat cerebral cortex. This effect increased with increasing protoveratrine concentration, reaching a maximum at 100 microM. 2. Removal of Ca2+ from the superfusing medium did not change the increase in release due to 10 microM-protoveratrine; however, the Ca2+ antagonists, compound D-600, La3+, Mn2+, Mg2+ and also high Ca2+ concentration inhibited the effect of the alkaloid, as did procaine. 3. Protoveratrine A increased the uptake of 22Na+ into the slices with a similar dose-response curve to that found for gamma-aminobutyrate release. For the most part, the substances that inhibited protoveratrine-stimulated gamma-aminobutyrate release also inhibited 22Na+ uptake, although the correlation was not perfect. 4. Although extracellular Ca2+ is not required for protoveratrine-induced gamma-aminobutyrate release, an increase in Na+ influx that is susceptible to inhibition by some Ca2+ antagonists does appear to be associated with this phenomenon. However, the possibility remains that changes in the free intracellular Ca2+ concentration may be important for transmitter release induced by depolarizing veratrum alkaloids.

Na+ influx-induced decrease of (Na++ K+) -ATPase activity in rat brain slices: role of Ca2+

1991 ◽  
Vol 204 (3) ◽  
pp. 257-263 ◽  
Author(s):  
Matsuda Toshio ◽  
Shimizu Isao ◽  
Baba Akemichi
Keyword(s):  
Atpase Activity ◽  
Rat Brain ◽  
Brain Slices

scholarly journals Role of the Hyperpolarization‐Activated Cation Current ( I h ) in Pacemaker Activity in Area Postrema Neurons of Rat Brain Slices

2003 ◽  
Vol 552 (1) ◽  
pp. 135-148 ◽  
Author(s):  
Makoto Funahashi ◽  
Yoshihiro Mitoh ◽  
Atsushi Kohjitani ◽  
Ryuji Matsuo
Keyword(s):  
Rat Brain ◽  
Area Postrema ◽  
Brain Slices ◽  
Pacemaker Activity ◽  
Cation Current

Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxygenation

2013 ◽  
Vol 24 (12) ◽  
pp. 2152-2157 ◽  
Author(s):  
Susana Cabrerizo ◽  
José Pedro De La Cruz ◽  
Juan Antonio López-Villodres ◽  
Javier Muñoz-Marín ◽  
Ana Guerrero ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Inflammatory Mediators ◽  
Brain Slices ◽  
Neuroprotective Effects ◽  
Hypoxia Reoxygenation
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