Nitro derivatives of the thiophene series. 4. Nitration of thiophene derivatives with metal nitrates in acetic anhydride

1981 ◽  
Vol 17 (7) ◽  
pp. 673-675 ◽  
Author(s):  
Yu. D. Churkin ◽  
L. V. Panfilova ◽  
V. D. Lugovoi ◽  
N. V. Boiko
Keyword(s):  
Acetic Anhydride ◽  
Thiophene Series ◽  
Metal Nitrates ◽  
Nitro Derivatives ◽  
Thiophene Derivatives ◽  
Derivatives Of

ChemInform Abstract: NITRO DERIVATIVES OF THE THIOPHENE SERIES. 4. NITRATION OF THIOPHENE DERIVATIVES BY METAL NITRATES IN ACETIC ANHYDRIDE

1981 ◽  
Vol 12 (50) ◽  
Author(s):  
YU. D. CHURKIN ◽  
L. V. PANFILOVA ◽  
V. D. LUGOVOI ◽  
N. V. BOIKAO
Keyword(s):  
Acetic Anhydride ◽  
Thiophene Series ◽  
Metal Nitrates ◽  
Nitro Derivatives ◽  
Thiophene Derivatives ◽  
Derivatives Of

Nitro derivatives of the thiophene series. 2. Nitration of thienyl-substituted unsaturated methyl ketones

1981 ◽  
Vol 17 (3) ◽  
pp. 232-235 ◽  
Author(s):  
Yu. D. Churkin ◽  
L. V. Panfilova ◽  
A. S. Shashkov ◽  
K. Ya. Burshtein
Keyword(s):  
Methyl Ketones ◽  
Thiophene Series ◽  
Nitro Derivatives ◽  
Derivatives Of

Nitration of 3,4-Dimethylacetophenone and 3,4-Dimethylbenzophenone. Formation and Rearomatization of Adducts

1975 ◽  
Vol 53 (11) ◽  
pp. 1570-1578 ◽  
Author(s):  
Alfred Fischer ◽  
Colin Campbell Greig ◽  
Rolf Röderer
Keyword(s):  
Acetic Acid ◽  
Acetic Anhydride ◽  
Nitro Group ◽  
Nitrous Acid ◽  
Main Product ◽  
Intermediate Formation ◽  
Nitro Derivatives ◽  
Acidic Conditions ◽  
Cis And Trans ◽  
Derivatives Of

Nitration of 3,4-dimethylacetophenone in acetic anhydride gives a mixture of cis-and trans-2-acetyl-4,5-dimethyl-4-nitro-1,4-dihydrophenyl acetate as the main product, together with 3,4-dimethyl-2-, 3,4-dimethyl-5-, and 3,4-dimethyl-6-nitroacetophenone. Analogous products are obtained from 3,4-dimethylbenzophenone. Rearomatization of the adducts under mildly acidic conditions occurs via 1,4-elimination of nitrous acid to form 2-acetyl- and 2-benzoyl-4,5-dimethylphenyl acetate, respectively. In strongly acidic conditions elimination of acetic acid accompanied by 1,2- and 1,3-shifts of the nitro group occurs to form the 2- and 5-nitro derivatives of the parent ketones. The rearomatization to the nitro derivatives involves the intermediate formation of an ipso-cyclohexadienyl cation which may be trapped by anisole or mesitylene to form biphenyl derivatives.

ChemInform Abstract: NITRO DERIVATIVES OF THE THIOPHENE SERIES. 3. STUDY OF THE NITRATION OF THIOPHENE α,β-UNSATURATED KETONES IN THE PRESENCE OF PROTONIC AND APROTIC ACIDS

1981 ◽  
Vol 12 (44) ◽  
Author(s):  
YU. D. CHURKIN ◽  
L. V. PANFILOVA ◽  
A. S. SHASHKOV ◽  
K. YA. BURSHTEIN
Keyword(s):  
Unsaturated Ketones ◽  
Thiophene Series ◽  
Nitro Derivatives ◽  
Derivatives Of

Nitro derivatives of the thiophene series. 3. Study of the nitration of thiophene ?,?-unsaturated ketones in the presence of protic and aprotic acids

1981 ◽  
Vol 17 (6) ◽  
pp. 549-552
Author(s):  
Yu. D. Churkin ◽  
L. V. Panfilova ◽  
A. S. Shashkov ◽  
K. Ya. Burshtein
Keyword(s):  
Unsaturated Ketones ◽  
Thiophene Series ◽  
Nitro Derivatives ◽  
Derivatives Of

ChemInform Abstract: NITRO DERIVATIVES OF THE THIOPHENE SERIES. 2. NITRATION OF THIOPHENE UNSATURATED METHYL KETONES

1981 ◽  
Vol 12 (35) ◽  
Author(s):  
YU. D. CHURKIN ◽  
L. V. PANFILOVA ◽  
A. S. SHASHKOV ◽  
K. YA. BURSHTEIN
Keyword(s):  
Methyl Ketones ◽  
Thiophene Series ◽  
Nitro Derivatives ◽  
Derivatives Of

QSAR Analysis of Selected Antimicrobial Structures Belonging to Nitro-derivatives of Heterocyclic Compounds

2020 ◽  
Vol 17 (2) ◽  
pp. 214-225 ◽  
Author(s):  
Piotr Kawczak ◽  
Leszek Bober ◽  
Tomasz Bączek
Keyword(s):  
Antimicrobial Activity ◽  
Heterocyclic Compounds ◽  
Molecular Descriptors ◽  
Microbiological Activity ◽  
Activity Data ◽  
Qsar Analysis ◽  
Qsar Models ◽  
Nitro Derivatives ◽  
Semi Empirical ◽  
Derivatives Of

Background: Nitro-derivatives of heterocyclic compounds were used as active agents against pathogenic microorganisms. A set of 4- and 5-nitroimidazole derivatives exhibiting antimicrobial activity was analyzed with the use of Quantitative Structure-Activity Relationships (QSAR) method. The study included compounds used both in documented treatment and those described as experimental. Objective: The purpose of this study was to demonstrate the common and differentiating characteristics of the above-mentioned chemical compounds alike physicochemically as well as pharmacologically based on the quantum chemical calculations and microbiological activity data. Methods: During the study PCA and MLR analysis were performed, as the types of proposed chemometric approach. The semi-empirical and ab initio level of in silico molecular modeling was performed for calculations of molecular descriptors. Results: QSAR models were proposed based on chosen descriptors. The relationship between the nitro-derivatives structure and microbiological activity data was able to class and describe the antimicrobial activity with the use of statistically significant molecular descriptors. Conclusion: The applied chemometric approaches revealed the influential features of the tested structures responsible for the antimicrobial activity of studied nitro-derivatives.

Electrochemical reduction of para-substituted 2-acyl-5-phenylfuranes in dimethylformamide

1981 ◽  
Vol 46 (2) ◽  
pp. 498-502 ◽  
Author(s):  
Jozef Černák ◽  
František Tomanovič ◽  
Andrej Staško ◽  
Anna Fedosyevna Oleinikova ◽  
Jaroslav Kováč
Keyword(s):  
Electrochemical Reduction ◽  
Unpaired Electron ◽  
Anion Radical ◽  
Electron Wave ◽  
Epr Method ◽  
Electron Center ◽  
Nitrogen Nucleus ◽  
Nitro Derivatives ◽  
Stable Anion ◽  
Derivatives Of

para Substituted chloro, bromo, and nitro derivatives of 2-acyl-5-phenylfurane are reduced polarographically in a one-electron wave to the corresponding anion radicals, which were studied by the EPR method. The reduction of nitro derivatives, studied by the Kalousek switch, is reversible and leads to a stable anion radical with an unpaired electron center on the nitrogen nucleus; the reduction of the halogen derivatives is only partly reversible and leads to unstable ketyl radicals. The bromo derivatives give polarographic maxima typical for concurrent reactions.

Synthesis of 5,7-dihydroxynaphthoquinone derivatives and their reactions with nucleophiles: Nitration of 2,3-dimethylnaphthalene and subsequent transformations

1976 ◽  
Vol 29 (10) ◽  
pp. 2247 ◽  
Author(s):  
HJ Banks ◽  
DW Cameron ◽  
MJ Crossley ◽  
EL Samuel
Keyword(s):  
Unusual Reaction ◽  
Nitro Derivatives ◽  
Reactions With Nucleophiles ◽  
Derivatives Of ◽  
Related Compounds ◽  
Benzenoid Ring

5,7-Dihydroxy-2,3-dimethyl-l,4-naphthoquinone (5) and related compounds have been synthesized. The quinone affords an accessible substrate for studying an unusual reaction with nucleophiles, which involves attack at the 8-position, i.e. at the benzenoid ring. An unsuccessful approach to (5) has led to tri- and tetra-nitro derivatives of 2,3-dimethylnaphthalene. Reduction of the former and subsequent conversions have given aminonaphthoquinone and perimidinone derivatives.

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