Kidney transplantation in hepatitis B surface antigen carriers

1994 ◽  
Vol 72 (12) ◽  
pp. 1000-1006 ◽  
Author(s):  
V. Kliem ◽  
B. Ringe ◽  
K. Holhorst ◽  
U. Freei
2005 ◽  
Vol 37 (6) ◽  
pp. 2467-2468 ◽  
Author(s):  
M. Veroux ◽  
C. Puliatti ◽  
M. Macarone ◽  
D. Cappello ◽  
M. Gagliano ◽  
...  

2020 ◽  
Vol 27 (7) ◽  
pp. 739-746 ◽  
Author(s):  
Jihye Kim ◽  
Se Jin Chung ◽  
Dong Hyun Sinn ◽  
Kyo Won Lee ◽  
Jae Berm Park ◽  
...  

2020 ◽  
Vol 34 (1) ◽  
pp. S107-S107
Author(s):  
Hyejin Mo ◽  
Sangil Min ◽  
Ahram Han ◽  
In Mok Jung ◽  
Jongwon Ha

Author(s):  
Xian-ding Wang ◽  
Jin-peng Liu ◽  
Tu-run Song ◽  
Zhong-li Huang ◽  
Yu Fan ◽  
...  

Abstract Background Data on kidney transplantation (KTx) from hepatitis B surface antigen (HBsAg)–positive (HBsAg+) donors to HBsAg-negative (HBsAg−) recipients [D(HBsAg+)/R(HBsAg-)] are limited. We aimed to report the outcomes of D(HBsAg+)/R(HBsAg−) KTx in recipients with or without hepatitis B surface antibody (HBsAb). Methods Eighty-three D(HBsAg+)/R(HBsAg−) living KTx cases were retrospectively identified. The 384 cases of KTx from hepatitis B core antibody–positive (HBcAb+) living donors to HBcAb-negative (HBcAb−) recipients [D(HBcAb+)/R(HBcAb−)] were used as the control group. The primary endpoint was posttransplant HBsAg status change from negative to postive (-− →+). Results Before KTx, 24 donors (28.9%) in the D(HBsAg+)/R(HBsAg−) group were hepatitis B virus (HBV) DNA positive, and 20 recipients were HBsAb−. All 83 D(HBsAg+)/R(HBsAg−) recipients received HBV prophylaxis, while no D(HBcAb+)/R(HBcAb−) recipients received prophylaxis. After a median follow-up of 36 months (range, 6–106) and 36 months (range, 4–107) for the D(HBsAg+)/R(HBsAg−) and D(HBcAb+)/R(HBcAb−) groups, respectively, 2 of 83 (2.41%) D(HBsAg+)/R(HBsAg−) recipients and 1 of 384 (0.26%) D(HBcAb+)/R(HBcAb−) became HBsAg+, accompanied by HBV DNA-positive (P = .083). The 3 recipients with HBsAg−→+ were exclusively HBsAb−/HBcAb− before KTx. Recipient deaths were more frequent in the D(HBsAg+)/R(HBsAg−) group (6.02% vs 1.04%, P = .011), while liver and graft function, rejection, infection, and graft loss were not significantly different. In univariate analyses, pretransplant HBsAb−/HBcAb− combination in the D(HBsAg+)/R(HBsAg−) recipients carried a significantly higher risk of HBsAg−→+, HBV DNA−→+, and death. Conclusions Living D(HBsAg+)/R(HBsAg−) KTx in HBsAb+ recipients provides excellent graft and patient survivals without HBV transmission. HBV transmission risks should be more balanced with respect to benefits of D(HBsAg+)/R(HBsAg−) KTx in HBsAb-/HBcAb− candidates.


1999 ◽  
Vol 31 (7) ◽  
pp. 2869 ◽  
Author(s):  
M Okamoto ◽  
N Yoshimura ◽  
I Nakai ◽  
H Nakajima ◽  
N Mizuta ◽  
...  

2015 ◽  
Vol 68 ◽  
pp. 32-36 ◽  
Author(s):  
Valérie Moal ◽  
Anne Motte ◽  
Henri Vacher-Coponat ◽  
Catherine Tamalet ◽  
Yvon Berland ◽  
...  

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