Bicyclic resin acids of the oleoresins of Pinus mugo and P. strobus

1988 ◽  
Vol 24 (2) ◽  
pp. 260-260
Author(s):  
V. I. Bol'shakova ◽  
�. N. Shmidt ◽  
V. A. Pentegova
Keyword(s):  
Resin Acids ◽  
Pinus Mugo

Substitution reactions of aromatic resin acids

1960 ◽  
Author(s):  
Virgil Irvin Stenberg
Keyword(s):  
Resin Acids ◽  
Substitution Reactions

Fatty and Resin Acids Recovered from Spruce Wood by Supercritical Acetone Extraction

Holzforschung ◽  
1991 ◽  
Vol 45 (5) ◽  
pp. 337-339 ◽  
Author(s):  
Ayhan Demirbaş
Keyword(s):  
Resin Acids ◽  
Acetone Extraction ◽  
Spruce Wood

Cytochrome P450 mono-oxygenases in conifer genomes: discovery of members of the terpenoid oxygenase superfamily in spruce and pine

2006 ◽  
Vol 34 (6) ◽  
pp. 1209-1214 ◽  
Author(s):  
B. Hamberger ◽  
J. Bohlmann
Keyword(s):  
Cytochrome P450 ◽  
Loblolly Pine ◽  
Large Scale ◽  
Expressed Sequence Tag ◽  
Resin Acid ◽  
Functional Characterization ◽  
Structural Diversity ◽  
Resin Acids ◽  
Full Length Sequence ◽  
Diterpene Resin Acids

Diterpene resin acids, together with monoterpenes and sesquiterpenes, are the most prominent defence chemicals in conifers. These compounds belong to the large group of structurally diverse terpenoids formed by enzymes known as terpenoid synthases. CYPs (cytochrome P450-dependent mono-oxygenases) can further increase the structural diversity of these terpenoids. While most terpenoids are characterized as specialized or secondary metabolites, some terpenoids, such as the phytohormones GA (gibberellic acid), BRs (brassinosteroids) and ABA (abscisic acid), have essential functions in plant growth and development. To date, very few CYP genes involved in conifer terpenoid metabolism have been functionally characterized and were limited to two systems, yew (Taxus) and loblolly pine (Pinus taeda). The characterized yew CYP genes are involved in taxol diterpene biosynthesis, while the only characterized pine terpenoid CYP gene is part of DRA (diterpene resin acid) biosynthesis. These CYPs from yew and pine are members of two apparently conifer-specific CYP families within the larger CYP85 clan, one of four plant CYP multifamily clans. Other CYP families within the CYP85 clan were characterized from a variety of angiosperms with functions in terpenoid phytohormone metabolism of GA, BR, and ABA. The recent development of EST (expressed sequence tag) and FLcDNA (where FL is full-length) sequence databases and cDNA collections for species of two conifers, spruce (Picea) and pine, allows for the discovery of new terpenoid CYPs in gymnosperms by means of large-scale sequence mining, phylogenetic analysis and functional characterization. Here, we present a snapshot of conifer CYP data mining, discovery of new conifer CYPs in all but one family within the CYP85 clan, and suggestions for their functional characterization. This paper will focus on the discovery of conifer CYPs associated with diterpene metabolism and CYP with possible functions in the formation of GA, BR, and ABA in conifers.

Fungistaxic effects of Pinus radiata needle epicuticular fatty and resin acids on Dothistroma pini

1983 ◽  
Vol 23 (2) ◽  
pp. 183-195 ◽  
Author(s):  
R.A. Franich ◽  
P.D. Gadgil ◽  
L. Shain
Keyword(s):  
Pinus Radiata ◽  
Resin Acids ◽  
Dothistroma Pini

(1416) Proposal to conserve the name Pinus mugo (Pinaceae) with a conserved type

Taxon ◽  
1999 ◽  
Vol 48 (3) ◽  
pp. 571-572 ◽  
Author(s):  
Enio Nardi ◽  
Paolo Minghetti
Keyword(s):  
Pinus Mugo

Resin acids. XIV. Synthesis of methyl 13,16-cycloatisan-18-oate (methyl anti-trachylobanate)

1968 ◽  
Vol 33 (11) ◽  
pp. 4210-4219 ◽  
Author(s):  
Werner Herz ◽  
Robert N. Mirrington ◽  
Harry Young ◽  
Yong Yeng Lin
Keyword(s):  
Resin Acids

scholarly journals Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties

2021 ◽  
Vol 14 (5) ◽  
pp. 422
Author(s):  
Kseniya Kovaleva ◽  
Olga Yarovaya ◽  
Konstantin Ponomarev ◽  
Sergey Cheresiz ◽  
Amirhossein Azimirad ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Study ◽  
Biological Properties ◽  
Glioma Cell Line ◽  
Resin Acids ◽  
Adamantane Derivatives ◽  
Molecular Docking Study ◽  
Design Synthesis ◽  
Low Cytotoxicity ◽  
Covalent Intermediate

In this paper, a series of novel abietyl and dehydroabietyl ureas, thioureas, amides, and thioamides bearing adamantane moieties were designed, synthesized, and evaluated for their inhibitory activities against tyrosil-DNA-phosphodiesterase 1 (TDP1). The synthesized compounds were able to inhibit TDP1 at micromolar concentrations (0.19–2.3 µM) and demonstrated low cytotoxicity in the T98G glioma cell line. The effect of the terpene fragment, the linker structure, and the adamantane residue on the biological properties of the new compounds was investigated. Based on molecular docking results, we suppose that adamantane derivatives of resin acids bind to the TDP1 covalent intermediate, forming a hydrogen bond with Ser463 and hydrophobic contacts with the Phe259 and Trp590 residues and the oligonucleotide fragment of the substrate.

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