Bronchodilator effect and serum theophylline level after combined treatment with fenoterol and theophylline in reversible chronic airflow obstruction

1988 ◽  
Vol 35 (6) ◽  
pp. 669-671
Author(s):  
M. I. Lucena ◽  
J. Almagro ◽  
F. Rius ◽  
F. Sanchez de la Cuesta
Keyword(s):  
Combined Treatment ◽  
Airflow Obstruction ◽  
Serum Theophylline ◽  
Bronchodilator Effect ◽  
Theophylline Level ◽  
Serum Theophylline Level

scholarly journals Salivary and Urine Theophylline Levels in Management of Childhood Asthma

1981 ◽  
Vol 74 (6) ◽  
pp. 415-418 ◽  
Author(s):  
S J Goldsworthy ◽  
M Kemp ◽  
J O Warner
Keyword(s):  
Body Weight ◽  
Surface Area ◽  
Childhood Asthma ◽  
Slow Release ◽  
Simple Method ◽  
Serum Theophylline ◽  
Theophylline Level ◽  
Serum Theophylline Level ◽  
Plasma Theophylline ◽  
Urine Levels

It is not possible to predict the plasma theophylline levels that can be achieved using slow-release aminophylline based on body weight or surface area. Improvement in FEV1 is directly related to increasing serum theophylline level, justifying the need for measuring levels in order to optimize therapy. As repeated venesection in children is unpleasant we have studied a simple method using saliva. Simultaneous blood and salivary theophylline levels correlated sufficiently well for salivary levels to be used for monitoring purposes. Urine levels did not correlate as well, but could be used for checking compliance.

Efficacy of a 12-Hour Sustained-Release Preparation in Maintaining Therapeutic Serum Theophylline Levels in Asthmatic Children

PEDIATRICS ◽  
1980 ◽  
Vol 66 (1) ◽  
pp. 97-102
Author(s):  
H. William Kelly ◽  
Shirley Murphy
Keyword(s):  
Sustained Release ◽  
Age Groups ◽  
Serum Theophylline ◽  
Asthmatic Children ◽  
Theophylline Level ◽  
Serum Theophylline Level ◽  
Significant Difference ◽  
Sustained Release Theophylline ◽  
The Mean ◽  
Two Age Groups

The purpose of this study was to determine whether a new sustained-release theophylline preparation TheoDur could maintain therapeutic serum theophylline levels in asthmatic children on a 12-hour dosage regimen. Twenty asthmatic children aged 6 to 18 years with a mean of 11.4 years who required continuous theophylline therapy for control of their asthma were enrolled in the study. Each patient's dosage was titrated to achieve a six-hour postdose serum theophylline level between 10 and 20 µg/ml. The patients required a mean ± SEM dose of 10.0 ± 0.54 mg/kg every 12 hours which gave a mean ± SEM six-hour postdose serum theophylline level of 15.65 ± 0.72 µg/ml. At the end of five days on this dosage, the patients were admitted and serum theophylline levels were determined every three hours for 24 hours. The mean ± SEM difference between maximum and minimum serum theophylline levels (ΔTL) for the group was 4.5 ± 0.3 µg/ml. There was not a significant difference in the ΔTL between the two age groups (6 to 9 years, 4.5 ± 0.5 µg/ml and 10 to 18 years 4.5 ± 0.4 µg/ml). In conclusion, TheoDur will maintain therapeutic serum theophylline levels with minimal fluctuations in asthmatic children on a 12-hour dosing schedule.

Letter to the Editor

PEDIATRICS ◽  
1982 ◽  
Vol 70 (3) ◽  
pp. 509-509
Author(s):  
Michael J. Kraemer ◽  
Clifton T. Furukawa ◽  
Jeffrey Koup ◽  
Gail G. Shapiro ◽  
William E. Pierson ◽  
...  
Keyword(s):  
Chronic Asthma ◽  
Serum Theophylline ◽  
Theophylline Level ◽  
Letter To The Editor ◽  
Serum Theophylline Level

We thank Walker and Middelkamp for sharing their experiences. We also would like to emphasize Weinberger's point that when nausea, vomiting, or headache are present in nonwheezing children, additional theophylline administration should always be withheld until a serum theophylline level is measured. Theophylline continues to be very effective in the treatment of chronic asthma, and its use is to be encouraged. However, for optimal benefits with minimal risks, serum theophylline determinations must be rapidly obtainable.

Albumin-Collodion Activated Charcoal Hemoperfusion in the Treatment of Severe Theophylline Intoxication in a 3-Year-Old Patient

PEDIATRICS ◽  
1980 ◽  
Vol 65 (4) ◽  
pp. 811-814 ◽  
Author(s):  
Thomas M. S. Chang ◽  
Enrique Espinosa-Meléndez ◽  
Thomas E. Francoeur ◽  
Norman R. Eade
Keyword(s):  
Activated Charcoal ◽  
Serum Theophylline ◽  
Theophylline Level ◽  
Serum Theophylline Level ◽  
Charcoal Hemoperfusion ◽  
Theophylline Intoxication

During treatment for asthma, a 3-year-old, 15-kg child was given 750 mg of theophylline in error. Within three hours she was treated with albumin-collodion activated charcoal (ACAC) hemoperfusion. Immediately before treatment her serum theophylline level was 74 µg/ml. At the end of three hours of hemoperfusion, her theophylline level had fallen to 14.4 µg/ml and four hours later it was 8.8 µg/ml. The ACAC hemoperfusion system completely removed all the theophylline passing through it without saturation, and the total amount of drug removed was 500.8 mg (more than two thirds of the dose administered). The technique described is an efficient and rapidly effective method for the treatment of potentially lethal theophylline intoxication. For maximum effectiveness, it must be instituted as soon after intoxication as possible.

scholarly journals Comparison of serum theophylline level determinations by Vision Analyzer and fluorescence polarization immunoassay.

1989 ◽  
Vol 38 (11) ◽  
pp. T179-T182
Author(s):  
Yasuhiro NAKAHARA ◽  
Yuko YOSHIOKA ◽  
Masahiro MURATA ◽  
Syuhei KURASHINA ◽  
Kyoko ISANO ◽  
...  
Keyword(s):  
Fluorescence Polarization ◽  
Fluorescence Polarization Immunoassay ◽  
Serum Theophylline ◽  
Theophylline Level ◽  
Serum Theophylline Level

Treatment of Theophylline Poisoning

PEDIATRICS ◽  
1992 ◽  
Vol 90 (5) ◽  
pp. 780-781
Author(s):  
ARTHUR STRAUSS ◽  
HOUCHANG D. MODANL0U
Keyword(s):  
Activated Charcoal ◽  
Invasive Procedure ◽  
Postoperative Phase ◽  
Serum Theophylline ◽  
Theophylline Level ◽  
Arterial Switch ◽  
Serum Theophylline Level ◽  
Multiple Exchange ◽  
Theophylline Poisoning ◽  
Multiple Complication

To the Editor.— We were interested in the report by Shannon and co-workers1 in which they described the use of multiple exchange transfusions for the treatment of an accidental toxic serum theophylline level in an infant in the postoperative phase of an arterial switch procedure. Although we have no problem with the rationale used for an invasive procedure that has multiple complication risks, we would like to emphasize the option for the use of activated charcoal products in infants who are able to tolerate orally administered medications.

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