DNA ploidy and S-phase fraction in medullary carcinoma of the breast -a flow cytometric analysis using archival material

1994 ◽  
Vol 29 (3) ◽  
pp. 297-306 ◽  
Author(s):  
Lise Pedersen ◽  
J�rgen K. Larsen ◽  
Ib Jarle Christensen ◽  
Anne Lykkesfeldt ◽  
Susanne Holck ◽  
...  
Keyword(s):  
Dna Ploidy ◽  
Flow Cytometric Analysis ◽  
Medullary Carcinoma ◽  
S Phase ◽  
Phase Fraction ◽  
Carcinoma Of The Breast ◽  
Archival Material ◽  
Flow Cytometric

scholarly journals Flow cytometric analysis of DNA ploidy and S-phase fraction from prostatic carcinomas: implications for prognosis and response to endocrine therapy

1991 ◽  
Vol 64 (3) ◽  
pp. 578-582 ◽  
Author(s):  
T Visakorpi ◽  
O-P Kallioniemi ◽  
IYI Paronen ◽  
JJ Isola ◽  
AI Heikkinen ◽  
...  
Keyword(s):  
Endocrine Therapy ◽  
Dna Ploidy ◽  
Flow Cytometric Analysis ◽  
S Phase ◽  
Phase Fraction ◽  
Flow Cytometric

Flow Cytometric Analysis of DNA Ploidy and S-Phase Fraction in Primary Localized Myxofibrosarcoma: Correlations with Clinicopathological Factors, Skp2 Expression, and Patient Survival

2008 ◽  
Vol 15 (8) ◽  
pp. 2239-2249 ◽  
Author(s):  
Hsuan-Ying Huang ◽  
Wen-Wei Huang ◽  
Jing-Mei Wu ◽  
Chiung-Kuei Huang ◽  
Jun-Wen Wang ◽  
...  
Keyword(s):  
Patient Survival ◽  
Dna Ploidy ◽  
Flow Cytometric Analysis ◽  
S Phase ◽  
Phase Fraction ◽  
Clinicopathological Factors ◽  
Skp2 Expression ◽  
Flow Cytometric

Flow cytometric DNA ploidy and S-phase fraction correlate with histopathologic indicators of tumor behavior in colorectal carcinoma

1997 ◽  
Vol 40 (4) ◽  
pp. 411-419 ◽  
Author(s):  
António E. Pinto ◽  
Paula Chaves ◽  
Paulo Fidalgo ◽  
António G. Oliveira ◽  
Carlos N. Leitøo ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Dna Ploidy ◽  
S Phase ◽  
Phase Fraction ◽  
Flow Cytometric

scholarly journals DNA flow cytometric analysis of primary operable breast cancer. Relation of ploidy and S-Phase fraction to outcome of patients in NSABP B-04

Cancer ◽  
1991 ◽  
Vol 68 (7) ◽  
pp. 1465-1475 ◽  
Author(s):  
Bernard Fisher ◽  
Nurten Gunduz ◽  
Joseph Costantino ◽  
Edwin R. Fisher ◽  
Carol Redmond ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Flow Cytometric Analysis ◽  
Operable Breast Cancer ◽  
S Phase ◽  
Phase Fraction ◽  
Flow Cytometric ◽  
Primary Operable Breast Cancer

scholarly journals Flow cytometric analysis of S-phase fraction in breast carcinomas using gating on cells containing cytokeratin

1994 ◽  
Vol 69 (3) ◽  
pp. 546-549 ◽  
Author(s):  
S Wingren ◽  
◽  
O Stål ◽  
B Nordenskjöld
Keyword(s):  
Flow Cytometric Analysis ◽  
S Phase ◽  
Phase Fraction ◽  
Breast Carcinomas ◽  
Flow Cytometric

Deoxyribonucleic acid flow cytometric analysis of cervical adenocarcinoma: Prognostic significance of deoxyribonucleic acid ploidy and S-phase fraction

1990 ◽  
Vol 162 (3) ◽  
pp. 848-853 ◽  
Author(s):  
Arto Leminen ◽  
Jorma Paavonen ◽  
Ervo Vesterinen ◽  
Matti Forss ◽  
Torsten Wahlström ◽  
...  
Keyword(s):  
Deoxyribonucleic Acid ◽  
Prognostic Significance ◽  
Flow Cytometric Analysis ◽  
S Phase ◽  
Cervical Adenocarcinoma ◽  
Phase Fraction ◽  
Flow Cytometric

The Flow-Cytometric Analysis of DNA Content and S-Phase Fraction (SPF) of Human Breast Cancer

1989 ◽  
Vol 185 (5) ◽  
pp. 694-697 ◽  
Author(s):  
M. Eskelinen ◽  
S. Nordling ◽  
J. Puittinen ◽  
E. Pesonen ◽  
Y. Collan
Keyword(s):  
Breast Cancer ◽  
Dna Content ◽  
Human Breast Cancer ◽  
Flow Cytometric Analysis ◽  
S Phase ◽  
Phase Fraction ◽  
Human Breast ◽  
Flow Cytometric

scholarly journals Flow Cytometric Analysis of DNA Index and S-phase Fraction in the Colonic Mucosa Adjacent to Colorectal Carcinoma

1991 ◽  
Vol 24 (9) ◽  
pp. 2486-2486
Author(s):  
Kazuhiko Yoshida ◽  
Akihiro Tanabe ◽  
Tatsuro Nakagawa ◽  
Hideyo Ishida ◽  
Toshiyuki Yoda ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Colonic Mucosa ◽  
Flow Cytometric Analysis ◽  
S Phase ◽  
Phase Fraction ◽  
Dna Index ◽  
Flow Cytometric

scholarly journals Evaluation of Prognostic Factors Following Flow-Cytometric DNA Analysis after Cytokeratin Labelling: II. Cervical and Endometrial Cancer

2002 ◽  
Vol 24 (4-5) ◽  
pp. 147-158 ◽  
Author(s):  
Pauline Wimberger ◽  
Peter Hillemanns ◽  
Thomas Kapsner ◽  
Hermann Hepp ◽  
Rainer Kimmig
Keyword(s):  
Cervical Cancer ◽  
Endometrial Cancer ◽  
Prognostic Factors ◽  
Endometrial Carcinoma ◽  
Dna Ploidy ◽  
S Phase ◽  
Phase Fraction ◽  
Dna Aneuploidy ◽  
Flow Cytometric

In gynecologic oncology valid prognostic factors are necessary to define biologically similar subgroups for analysis of therapeutic efficacy. This study is the first published prospective study concerning prognostic significance of DNA ploidy and S‐phase fraction in cervical and endometrial cancer following enrichment of tumor cells by cytokeratin labelling. Epithelial cells were labeled by FITC‐conjugated cytokeratin antibody (CK 5, 6, 8, and CK 17) prior to flow cytometric cell cycle analysis in 91 specimens of cervical cancer and 73 samples of endometrial cancer. In cervical cancer neither DNA‐ploidy nor S‐phase fraction were relevant prognostic parameters. But CV of the G0G1‐peak showed prognostic relevance in cervical cancer cells, even in multivariate analysis. This interesting observation, however, seems to have no therapeutic consequence due to the small discrimination capacity of CV. In endometrial carcinoma, gross DNA‐aneuploidy (DNA‐index > 1.3) and a high percentage of proliferating cells (>75th percentile) were univariate and multivariate highly significant prognostic factors for recurrence‐free survival. Especially DNA‐aneuploidy (DI>1.3) is one of the most important independent molecular biological prognostic factors. While diagnostic curettage we could identify risk patients even preoperatively by determination of the prognostic factors like histologic tumor type, grading, cervical involvement and DNA‐ploidy. Thereby these patients could be treated primarily in an oncologic center. In conclusion, our investigations showed that the determination of DNA‐ploidy should be done in endometrial carcinoma. In cervical cancer no clinical significance for determination of DNA‐parameters was found.

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