Flow cytometric analysis of the DNA distribution in human brain tumors

1979 ◽  
Vol 46 (1-2) ◽  
pp. 39-44 ◽  
Author(s):  
K. Kawamoto ◽  
F. Herz ◽  
R. C. Wolley ◽  
A. Hirano ◽  
H. Kajikawa ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Flow Cytometric Analysis ◽  
Human Brain Tumors ◽  
Flow Cytometric ◽  
Dna Distribution

Flow-cytometric DNA analysis and immunohistochemical measurement of Ki-67 and BUdR labeling indices in human brain tumors

1989 ◽  
Vol 70 (3) ◽  
pp. 379-384 ◽  
Author(s):  
Takafumi Nishizaki ◽  
Tetsuji Orita ◽  
Yasuhiro Furutani ◽  
Yukihide Ikeyama ◽  
Hideo Aoki ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Malignant Glioma ◽  
Dna Analysis ◽  
Labeling Index ◽  
Ki 67 ◽  
Content Type ◽  
Dna Aneuploidy ◽  
Human Brain Tumors ◽  
Flow Cytometric

✓ Cell proliferation potential was assessed by measuring the labeling indices of the monoclonal antibody Ki-67 and of 5-bromodeoxyuridine (BUdR), and the cellular deoxyribonucleic acid (DNA) content in 48 human brain tumors. The diagnostic and prognostic value of flow-cytometric DNA analysis was also evaluated using ethanol-fixed paraffin-embedded BUdR-labeled specimens; these were the same specimens as were used for measuring the BUdR and Ki-67 labeling indices. Both the Ki-67 and the BUdR labeling indices correlated with the degree of malignancy estimated from conventional histological preparations. The Ki-67 labeling index was 1.7 times greater than the BUdR labeling index. The relationship of DNA aneuploidy to the labeling indices or to morphology in cases of glioma was examined. All of the tumors with an aneuploid line corresponded to malignant glioma classified by histological criteria, although malignant glioma did not always show DNA aneuploidy. In addition, the cases with aneuploid lines showed high BUdR and Ki-67 labeling indices. The cell kinetic data, which indicate the biological character of tumors, allowed prediction of the prognosis of the patients with gliomas. In contrast, despite the presence of an aneuploid line, three of 13 meningiomas showed a benign histological pattern without an aggressive clinical course, and neither the Ki-67 nor the BUdR labeling index was high. These results indicate an unequivocal relationship between DNA aneuploidy and clinical behavior; in general, both labeling indices may prove to be objective indicators of the outcome of patients with brain tumors.

scholarly journals Human Brain Tumors and Simian Virus 40

1995 ◽  
Vol 87 (17) ◽  
pp. 1331-1331 ◽  
Author(s):  
F. MARTINI ◽  
M. D. MATTEI ◽  
L. IACCHERI ◽  
L. LAZZARIN ◽  
G. BARBANTI-BRODANO ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
Human Brain Tumors

Neurogenetics and the molecular biology of human brain tumors

Brain Tumors ◽  
2012 ◽  
pp. 83-101
Author(s):  
Ivan Radovanovic ◽  
Abhijit Guha
Keyword(s):  
Molecular Biology ◽  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors

Sterols in cerebrospinal fluid during nitrosourea chemotherapy of human brain tumors

1976 ◽  
Vol 8 (2) ◽  
pp. 127-141 ◽  
Author(s):  
Remo Fumagalli ◽  
Stefano Pezzotta ◽  
Anna R. Racca ◽  
Pietro Paoletti
Keyword(s):  
Cerebrospinal Fluid ◽  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors

Magnetic Field Dependence of 1/T1of Human Brain Tumors

1990 ◽  
Vol 25 (11) ◽  
pp. 1197-1205 ◽  
Author(s):  
N LUNDBOM ◽  
R D BROWN ◽  
S H KOENIG ◽  
T A LANSEN ◽  
M P VALSAMIS ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Brain Tumors ◽  
Human Brain ◽  
Field Dependence ◽  
Magnetic Field Dependence ◽  
Human Brain Tumors

Ultrastructure of concentric laminations in primary human brain tumors

1986 ◽  
Vol 71 (1-2) ◽  
pp. 83-87 ◽  
Author(s):  
H. Kamitani ◽  
H. Masuzawa ◽  
J. Sato ◽  
M. Okada
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors

The expression of Galβ1,4GlcNAc α2,6 sialyltransferase and α2,6-linked sialoglycoconjugates in human brain tumors

1996 ◽  
Vol 91 (3) ◽  
pp. 284-292 ◽  
Author(s):  
Yoichi Kaneko ◽  
Hirotaka Yamamoto ◽  
Donna S. Kersey ◽  
Karen J. Colley ◽  
J. E. Leestma ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors
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