In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines

1992 ◽  
Vol 30 (6) ◽  
pp. 417-422 ◽  
Author(s):  
Yoshikazu Sugimoto ◽  
Yuichiro Ohe ◽  
Kazuto Nishio ◽  
Tohru Ohmori ◽  
Yasuhiro Fujiwara ◽  
...  
Keyword(s):  
Cell Lines ◽  
Carcinoma Cell ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Gastric Carcinoma Cell ◽  
Cell Lung Carcinoma ◽  
Carcinoma Cell Lines ◽  
Gastric Carcinoma Cell Lines

Expression of the Vasopressin and Gastrin-Releasing Peptide Genes in Small Cell Lung Carcinoma Cell Lines

Pathobiology ◽  
1992 ◽  
Vol 60 (3) ◽  
pp. 136-142 ◽  
Author(s):  
Marleen A.E. Verbeeck ◽  
Jack P.M. Elands ◽  
Lou F.M.H. de Leij ◽  
Charles H.C.M. Buys ◽  
Desmond N. Carney ◽  
...  
Keyword(s):  
Cell Lines ◽  
Lung Carcinoma ◽  
Carcinoma Cell ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Gastrin Releasing Peptide ◽  
Carcinoma Cell Lines ◽  
Lung Carcinoma Cell

Notch1 controls cell invasion and metastasis in small cell lung carcinoma cell lines

Lung Cancer ◽  
2014 ◽  
Vol 86 (3) ◽  
pp. 304-310 ◽  
Author(s):  
Wael Abdo Hassan ◽  
Ryoji Yoshida ◽  
Shinji Kudoh ◽  
Koki Hasegawa ◽  
Kanako Niimori-Kita ◽  
...  
Keyword(s):  
Cell Lines ◽  
Lung Carcinoma ◽  
Cell Invasion ◽  
Carcinoma Cell ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Invasion And Metastasis ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Carcinoma Cell Lines

Proneurotensin/neuromedin N secreted from small cell lung carcinoma cell lines as a potential tumor marker

2008 ◽  
Vol 2 (12) ◽  
pp. 1620-1627 ◽  
Author(s):  
Shun-ichiro Ogura ◽  
Kumi Kaneko ◽  
Shoji Miyajima ◽  
Keiichi Ohshima ◽  
Ken Yamaguchi ◽  
...  
Keyword(s):  
Tumor Marker ◽  
Cell Lines ◽  
Lung Carcinoma ◽  
Carcinoma Cell ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Carcinoma Cell Lines ◽  
Neuromedin N

scholarly journals Clozapine Induces Autophagic Cell Death in Non-Small Cell Lung Cancer Cells

2015 ◽  
Vol 35 (3) ◽  
pp. 945-956 ◽  
Author(s):  
Yu-Chun Yin ◽  
Chao-Cheng Lin ◽  
Tzu-Ting Chen ◽  
Jen-Yeu Chen ◽  
Hui-Ju Tsai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Bafilomycin A1 ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Carcinoma Cell Lines

Background/Aims: Previous studies have shown that patients with schizophrenia have a lower incidence of cancer than the general population, and several antipsychotics have been demonstrated to have cytotoxic effects on cancer cells. However, the mechanisms underlying these results remain unclear. The present study aimed to investigate the effect of clozapine, which is often used to treat patients with refractory schizophrenia, on the growth of non-small cell lung carcinoma cell lines and to examine whether autophagy contributes to its effects. Methods: A549 and H1299 cells were treated with clozapine, and cell cytotoxicity, cell cycle and autophagy were then assessed. The autophagy inhibitor bafilomycin A1 and siRNA-targeted Atg7 were used to determine the role of autophagy in the effect of clozapine. Results: Clozapine inhibited A549 and H1299 proliferation and increased p21 and p27 expression levels, leading to cell cycle arrest. Clozapine also induced a high level of autophagy, but not apoptosis, in both cell lines, and the growth inhibitory effect of clozapine was blunted by treatment with the autophagy inhibitor bafilomycin A1 or with an siRNA targeting atg7. Conclusions: Clozapine inhibits cell proliferation by inducing autophagic cell death in two non-small cell lung carcinoma cell lines. These findings may provide insights into the relationship between clozapine use and the lower incidence of lung cancer among patients with schizophrenia.

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