Effect of hydrocortisone, deoxycorticosterone acetate, testosterone propionate, and estradiol dipropionate on incorporation of glycine-1-C14 into subcellular fractions of liver cells

1971 ◽  
Vol 72 (1) ◽  
pp. 755-757
Author(s):  
P. V. Sergeev ◽  
R. D. Seifulla ◽  
N. P. Saksonov
1960 ◽  
Vol XXXIV (IV) ◽  
pp. 536-542 ◽  
Author(s):  
Richard A. Edgren ◽  
Helene D. Neer

ABSTRACT In an earlier paper simultaneous testosterone propionate (TP) was shown to inhibit the vaginal smear effects of oestrone given over two days to spayed female mice. Deoxycorticosterone acetate (DCA) and progesterone were inactive in that test. Oestrone was given at a dose of 2 μg and the other steroid at 1000 μg. If these same doses were given over a four day period, however, all three steroids blocked the oestrone-induced changes. In a series of tests in which the oestrone was given over four days and the blocker either in one or two day periods, TP was found to antagonize when administered with the early but not with the late oestrone injections. DCA was an inhibitor only when given with the late oestrone administrations. The period of progesterone activity was midway between that for TP and that for DCA, and overlapped each. These patterns of response were best discriminated when the blocker was administered in a single injection.


1949 ◽  
Vol 27d (2) ◽  
pp. 37-42 ◽  
Author(s):  
D. G. Chapman ◽  
M. Gluck ◽  
R. H. Common ◽  
W. A. Maw

The serum vitamin A level of sexually immature pullets was increased threefold to fourfold by intramuscular injection of 24 mgm. estradiol dipropionate plus 4.5 mgm. testosterone propionate administered in six equal doses over a 12-day period as compared with the level in similar pullets receiving only testosterone propionate. It is suggested that gonadal hormone activity is one of the factors that regulate serum vitamin A levels in the domestic fowl.


1967 ◽  
Vol 50 (7) ◽  
pp. 1849-1864 ◽  
Author(s):  
E. Carafoli

After injection of 45Ca++ or 89Sr++ into rats, the largest part of the radioactivity in the liver cell is associated with the subcellular structures, only negligible amounts of it being found in the soluble hyaloplasm. 50 % or more of the 45Ca++ and 89Sr++ in the liver cell is recovered in the mitochondrial fraction. The specific activity of Ca++ after injection of 45Ca++ is far greater in mitochondria than in microsomes. Pretreatment of the rats with uncouplers of oxidative phosphorylation markedly decreases the amount of radioactivity associated with the mitochondrial fraction. The amount of radioactivity recovered in the microsomes and in the final supernatant on the contrary increases. These effects are present only when mitochondrial oxidative phosphorylation is completely uncoupled. The Ca++ content of mitochondria from the livers of rats pretreated with uncouplers is sharply decreased with respect to the controls. It is concluded that in the liver cells of the intact animal energy-linked movements of Ca++ and Sr++ take place in mitochondria.


1951 ◽  
Vol 7 (4) ◽  
pp. 318-320 ◽  
Author(s):  
P. L. KROHN

Intermenstrual bleeding in normal monkeys can readily be induced by DOCA and with more difficulty by testosterone propionate. The amount of DOCA required (c. 40–50 mg.) is greater than the amount of progesterone (c. 15–20 mg.) needed to induce bleeding. The amount of androgen required (c. 100 mg.) is higher still.


Sign in / Sign up

Export Citation Format

Share Document