Effect of estradiol dipropionate and testosterone propionate on the glycogen, lipid, and water contents of liver, muscle, and gonad of male and female (vitellogenic and nonvitellogenic) Singi fish (Heteropneustes fossilis bloch)

1982 ◽  
Vol 48 (4) ◽  
pp. 476-484 ◽  
Author(s):  
A.K. Dasmahapatra ◽  
A.K. Medda
Keyword(s):  
Testosterone Propionate ◽  
Heteropneustes Fossilis ◽  
Male And Female ◽  
Estradiol Dipropionate ◽  
Water Contents

GONADOTROPHIN PATTERNS IN MALE AND FEMALE RATS:

1968 ◽  
Vol 58 (4) ◽  
pp. 600-612 ◽  
Author(s):  
Robert Boyd ◽  
Donald C. Johnson
Keyword(s):  
Ascorbic Acid ◽  
Testosterone Propionate ◽  
Female Rats ◽  
Female Rat ◽  
Feedback Effects ◽  
Male And Female ◽  
Prostate Weight ◽  
Male And Female Rats ◽  
Males And Females ◽  
Normal Males

ABSTRACT The effects of various doses of testosterone propionate (TP) upon the release of luteinizing hormone (LH or ICSH) from the hypophysis of a gonadectomized male or female rat were compared. Prostate weight in hypophysectomized male parabiotic partners was used to evaluate the quantity of circulating LH. Hypophyseal LH was measured by the ovarian ascorbic acid depletion method. Males castrated when 45 days old secreted significantly more LH and had three times the amount of pituitary LH as ovariectomized females. Administration of 25 μg TP daily reduced the amount of LH in the plasma, and increased the amount in the pituitary gland, in both sexes. Treatment with 50 μg caused a further reduction in plasma LH in males, but not in females, while pituitary levels in both were equal to that of their respective controls. LH fell to the same low level in partners of males or females receiving 100 μg TP. When gonadectomized at 39 days, males and females had the same amount of plasma LH, but males had more stored hormone. Pituitary levels were unchanged from controls following treatment with 12.5, 25 or 50 μg TP daily, but plasma values dropped an equal amount in both sexes with the latter two doses. Androgenized males or females, gonadectomized when 39 days old, were very sensitive to the effects of TP and plasma LH was significantly reduced with 12.5 μg daily. Pituitary LH in androgenized males was higher than that of normal males but was reduced to normal by small amounts of TP. The amount of stored LH in androgenized females was not different from that of normal females and it was unchanged by any dose of TP tested. Results are consistent with the conclusion that the male hypothalamic-hypophyseal axis is at least as sensitive as the female axis to the negative feedback effects of TP. Androgenization increases the sensitivity to TP in both males and females.

INHIBITION OF SEXUAL DEVELOPMENT IN MALE AND FEMALE RATS TREATED WITH VARIOUS STEROIDS AT THE AGE OF FIVE DAYS

1965 ◽  
Vol 49 (2) ◽  
pp. 193-206 ◽  
Author(s):  
Fred A. Kind ◽  
A. Folch Pi ◽  
M. Maqueo ◽  
L. Herrera Lasso ◽  
A. Oriol ◽  
...  
Keyword(s):  
Sexual Development ◽  
Testosterone Propionate ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

ABSTRACT The effect of various steroids injected into 5 day old male and female rats was evaluated at the age of 45 days. In the males the degree in which testes and accessory sex tissues were atrophied, and in the females the degree of inhibition of luteinization were the indices. Various synthetic oestrogens were potent inhibitors of sexual development in both sexes while androgens were less active. The activity of several oestrogens in this test does not correlate with oestrogenic potency as measured in the uterotrophic test. Testosterone propionate produced moderate atrophy of testes and accessory sex tissue but spermatogenesis was not impaired.

PREVENTION OF CENTRAL DEFEMINIZATION BUT NOT MASCULINIZATION IN MALE RATS BY INHIBITION NEONATALLY OF OESTROGEN BIOSYNTHESIS

1977 ◽  
Vol 74 (3) ◽  
pp. 375-382 ◽  
Author(s):  
J. T. M. VREEBURG ◽  
PAULA D. M. VAN DER VAART ◽  
P. VAN DER SCHOOT
Keyword(s):  
Sexual Function ◽  
Ovarian Function ◽  
Testosterone Propionate ◽  
Neonatal Period ◽  
Female Rats ◽  
Male Rats ◽  
Normal Male ◽  
Male And Female ◽  
Male And Female Rats ◽  
Copulatory Behaviour

SUMMARY An inhibitor of aromatization, androsta-1,4,6-triene-3,17-dione (ATD), was administered to newborn male and female rats and various parameters of gonadal and sexual function were examined in adulthood. Males injected with 1 mg ATD on the day of birth (day 1) and on days 3, 5, 10 and 15 postnatally, subsequently (day 55) showed normal male and female copulatory behaviour, but were not able to maintain cyclicity in ovarian transplants. When the ATD was administered by Silastic implants, however, cyclicity in ovarian transplants did occur. Neither form of treatment brought about significant changes in neonatal plasma or testicular testosterone concentrations. Female rats implanted on day 3 of life with Silastic capsules containing ATD and then given an injection of 0·25 mg testosterone propionate on day 5 subsequently showed normal ovarian function, whereas the controls receiving only testosterone propionate showed persistent vaginal cornification, anovulation and polyfollicular ovaries. The results support the view that the central conversion of testicular androgens to oestrogens during the neonatal period is necessary to abolish cyclic gonadotrophin release and to suppress female copulatory behaviour.

THE EFFECTS OF GONADECTOMY AND THE ADMINISTRATION OF TESTOSTERONE PROPIONATE ON THE GROWTH OF ANTLERS IN MALE AND FEMALE DEER1

Endocrinology ◽  
1947 ◽  
Vol 40 (3) ◽  
pp. 202-224 ◽  
Author(s):  
GEORGE B. WISLOCKI ◽  
JOSEPH C. AUB ◽  
CHARLES M. WALDO
Keyword(s):  
Testosterone Propionate ◽  
Male And Female

STEROID FEEDBACK ON LUTEINIZING HORMONE SECRETION DURING SEXUAL MATURATION IN THE PIG

1978 ◽  
Vol 78 (3) ◽  
pp. 329-342 ◽  
Author(s):  
F. ELSAESSER ◽  
N. PARVIZI ◽  
F. ELLENDORFF
Keyword(s):  
Plasma Concentration ◽  
Testosterone Propionate ◽  
Hormone Secretion ◽  
Feedback Mechanism ◽  
Intact Male ◽  
Luteinizing Hormone Secretion ◽  
Strong Negative Correlation ◽  
Newborn Animal ◽  
Male And Female ◽  
Oestradiol Benzoate

The effects of gonadal secretions on the release of LH and the stimulation of LH secretion by oestradiol have been investigated in newborn male and female miniature pigs; the differences in the feedback action of testosterone in newborn and pubertal male pigs were also studied. Hemi-orchidectomy or orchidectomy of 1-week-old pigs had no effect on the level of LH in the plasma; total orchidectomy significantly reduced the levels of testosterone (P<0·01) and progesterone (P<0·05). In female pigs ovariectomized at 1 week of age, the concentration of LH in the plasma decreased, with a strong negative correlation between the level of LH and age (r = −0·41; P < 0·05). The plasma concentration of progesterone was generally low and unaffected by ovariectomy. Orchidectomy and treatment of male pigs, at 1 week of age, with testosterone (6 mg/kg body weight) had no effect on the plasma concentration of testosterone 24 h after treatment. If testosterone propionate was given rather than testosterone, the level of LH was significantly reduced (P< 0·001) 24 h after the injection and the concentration of testosterone in the plasma corresponded to that found in the intact adult male pig. Treatment with oestradiol or oestradiol benzoate did not affect the concentration of LH. Orchidectomy and treatment of pubertal male pigs with testosterone propionate resulted in a significantly (P < 0·001) higher concentration of testosterone in the plasma, compared with newborn pigs treated similarly, but the level of LH was unchanged. This suggests that there is a more rapid rate of clearance of testosterone in the newborn than in the pubertal male miniature pig and that the negative feedback of testosterone is not mediated by aromatization in the newborn animal and it declines before or during puberty. Treatment of newborn intact male and female and gonadectomized male pigs with oestradiol benzoate produced similar variations in the plasma level of oestradiol in all groups of animals. In the female pigs, however, a surge-like release of LH was observed 60–72 h after the injection of oestradiol benzoate, suggesting that the stimulatory feedback mechanism can operate soon after birth and that the response is sexually dimorphic.

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