Changing patterns of glucose metabolism during the course of subacute sclerosing panencephalitis as measured with18FDG-positron-emission tomography

1992 ◽  
Vol 239 (3) ◽  
pp. 157-161 ◽  
Author(s):  
M. Huber ◽  
G. Pawlik ◽  
S. Bamborschke ◽  
G. R. Finke ◽  
H. Karbe ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Glucose Metabolism ◽  
Subacute Sclerosing Panencephalitis ◽  
Emission Tomography ◽  
Positron Emission ◽  
Changing Patterns

Glucose metabolism evaluated by positron emission tomography in Lafora disease

1999 ◽  
Vol 41 (6) ◽  
pp. 689-692 ◽  
Author(s):  
ZENICHIRO Kato ◽  
KANJI Yasuda ◽  
KAZUNARI Ishii ◽  
HAJIME Takagi ◽  
SHINJI Mizuno ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Glucose Metabolism ◽  
Emission Tomography ◽  
Lafora Disease ◽  
Positron Emission

Detection of alterations in brain glucose metabolism by positron emission tomography in Takayasu?s arteritis

2004 ◽  
Vol 31 (2) ◽  
pp. 300-302 ◽  
Author(s):  
Stefan M. Weiner ◽  
Peter Vaith ◽  
Ulrich A. Walker ◽  
Ingo Brink
Keyword(s):  
Positron Emission Tomography ◽  
Glucose Metabolism ◽  
Emission Tomography ◽  
Brain Glucose ◽  
Brain Glucose Metabolism ◽  
Positron Emission

scholarly journals The Influence of Tissue Heterogeneity on Results of Fitting Nonlinear Model Equations to Regional Tracer Uptake Curves: With an Application to Compartmental Models Used in Positron Emission Tomography

1987 ◽  
Vol 7 (2) ◽  
pp. 214-229 ◽  
Author(s):  
K. Herholz ◽  
C. S. Patlak
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Glucose Metabolism ◽  
Capillary Permeability ◽  
Input Function ◽  
Tracer Uptake ◽  
Compartmental Models ◽  
Emission Tomography ◽  
Tissue Heterogeneity ◽  
Positron Emission

An analytical method based on Taylor expansions was developed to analyze errors caused by tissue heterogeneity in dynamic positron emission tomography (PET) measurements. Some general rules concerning the effect of parameter variances and covariances were derived. The method was further applied to various compartmental models currently used for measurement of blood flow, capillary permeability, glucose metabolism, and tracer binding. Blood flow and capillary permeability are shown to be generally underestimated in heterogenous tissue, the underestimation being more severe for slowly decaying, constant or increasing input functions rather than for bolus input, and increasing with measurement time. Typical errors caused by the heterogeneity due to insufficient separation between gray and white matter by a PET scanner with full width at half-maximum (FWHM)= 5 to 10 mm resolution range between–0.9 and–6% in dynamic CBF measurements with intravenous (i. v.) bolus injection of 15O-water or inhalation of 18F-fluoromethane and total measurement times of6 or 10 min, respectively. Binding or metabolic rates determined with tracers that are essentially trapped in tissue (e.g., FDG for measurement of cerebral glucose metabolism) are only slightly overestimated (0.5–3.0%) at typical measurement times and are essentially independent of the shape of the input function. The error increases considerably if tracer accumulation is very slow, however, or if short measurement times [<5/(k2 + k3)] are used. Some rate constants are also subject to larger errors.

scholarly journals Usefulness of Brain Positron Emission Tomography with Different Tracers in the Evaluation of Patients with Idiopathic Normal Pressure Hydrocephalous

2020 ◽  
Vol 21 (18) ◽  
pp. 6523
Author(s):  
Maria Vittoria Mattoli ◽  
Giorgio Treglia ◽  
Maria Lucia Calcagni ◽  
Annunziato Mangiola ◽  
Carmelo Anile ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Basal Ganglia ◽  
Glucose Metabolism ◽  
Pet Imaging ◽  
Surgical Outcome ◽  
D2 Receptor ◽  
Normal Pressure ◽  
Emission Tomography ◽  
Positron Emission ◽  
18F Fdg

Idiopathic normal pressure hydrocephalus (iNPH) is the only form of dementia that can be cured by surgery. Its diagnosis relies on clinical and radiological criteria. Identifying patients who can benefit from surgery is challenging, as other neurological diseases can be concomitant or mimic iNPH. We performed a systematic review on the role of positron emission tomography (PET) in iNPH. We retrieved 35 papers evaluating four main functional aspects with different PET radiotracers: (1) PET with amyloid tracers, revealing Alzheimer’s disease (AD) pathology in 20–57% of suspected iNPH patients, could be useful in predictions of surgical outcome. (2) PET with radiolabeled water as perfusion tracer showed a global decreased cerebral blood flow (CBF) and regional reduction of CBF in basal ganglia in iNPH; preoperative perfusion parameters could predict surgical outcome. (3) PET with 2-Deoxy-2-[18F]fluoroglucose ([18F]FDG ) showed a global reduction of glucose metabolism without a specific cortical pattern and a hypometabolism in basal ganglia; [18F]FDG PET may identify a coexisting neurodegenerative disease, helping in patient selection for surgery; postsurgery increase in glucose metabolism was associated with clinical improvement. (4) Dopaminergic PET imaging showed a postsynaptic D2 receptor reduction and striatal upregulation of D2 receptor after treatment, associated with clinical improvement. Overall, PET imaging could be a useful tool in iNPH diagnoses and treatment response.

scholarly journals The Effect of Diazepam Sedation on Cerebral Glucose Metabolism in Alzheimer's Disease as Measured Using Positron Emission Tomography

1987 ◽  
Vol 7 (4) ◽  
pp. 415-420 ◽  
Author(s):  
Norman L. Foster ◽  
Abraham F. L. VanDerSpek ◽  
Michael S. Aldrich ◽  
Stanley Berent ◽  
Richard H. Hichwa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Positron Emission Tomography ◽  
Glucose Metabolism ◽  
Metabolic Activity ◽  
Glucose Utilization ◽  
Activity Level ◽  
Emission Tomography ◽  
Positron Emission ◽  
Intravenous Diazepam

The effect of sedation induced by intravenous diazepam on cerebral glucose metabolic activity was examined with [18F]2-fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET) in five patients with probable Alzheimer's disease. Each subject was studied on 2 separate days: on one occasion at rest with eyes patched and ears open, and on the second when sedated with intravenous diazepam titrated to maintain stage II sleep by clinical and EEG criteria. Similar patterns of glucose uptake were observed in both the presence and the absence of sedation, but overall glucose utilization was depressed an average of 20% and was closely correlated with the amount of diazepam administered prior to the injection of FDG. The predominant temporoparietal hypometabolism and relative sparing of frontal metabolism observed in this disease are therefore not explained by differences in anxiety or activity level in this patient group. Utilization of diazepam sedation for PET study appears to be safe and may permit the study of patients otherwise unable to cooperate with FDG-PET procedures.

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