A-factor and streptomycin biosynthesis inStreptomyces griseus

Sucharu Horinouchi; Teruhiko Beppu

doi:10.1007/bf00873026

Streptomycin Biosynthesis and Metabolism

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)62588-8 ◽

1970 ◽

Vol 245 (24) ◽

pp. 6683-6689

Author(s):

Margaret S. Walker ◽

James B. Walker

Keyword(s):

Streptomycin Biosynthesis

Detection of an A-factor-responsive protein that binds to the upstream activation sequence of strR, a regulatory gene for streptomycin biosynthesis in Streptomyces griseus.

Journal of Bacteriology ◽

10.1128/jb.175.9.2652-2661.1993 ◽

1993 ◽

Vol 175 (9) ◽

pp. 2652-2661 ◽

Cited By ~ 56

Author(s):

D Vujaklija ◽

S Horinouchi ◽

T Beppu

Keyword(s):

Regulatory Gene ◽

Streptomyces Griseus ◽

Upstream Activation Sequence ◽

Streptomycin Biosynthesis ◽

Activation Sequence

Synthesis and absolute configuration of A-factor, the inducer of streptomycin biosynthesis in inactive mutants of

Tetrahedron Letters ◽

10.1016/s0040-4039(01)81924-9 ◽

1981 ◽

Vol 22 (35) ◽

pp. 3431-3432 ◽

Cited By ~ 17

Author(s):

Kenji Mori

Keyword(s):

Absolute Configuration ◽

Streptomycin Biosynthesis

Streptomycin biosynthesis. I. Existence of two amidinotransferase activities in Streptomyces griseus

Biochimica et Biophysica Acta (BBA) - Enzymology ◽

10.1016/0005-2744(71)90147-1 ◽

1971 ◽

Vol 242 (3) ◽

pp. 541-548 ◽

Cited By ~ 9

Author(s):

Luis Costa Plá

Keyword(s):

Streptomyces Griseus ◽

Streptomycin Biosynthesis

Streptomycin biosynthesis conversion of myo-inositol to O-phosphorylstreptidine

Biochimica et Biophysica Acta (BBA) - General Subjects ◽

10.1016/0304-4165(67)90072-4 ◽

1967 ◽

Vol 136 (2) ◽

pp. 272-278 ◽

Cited By ~ 15

Author(s):

Margaret S. Walker ◽

James B. Walker

Keyword(s):

Streptomycin Biosynthesis

Streptomycin biosynthesis. Enzymatic synthesis of O-phosphorylstreptidine from streptidine and adenosinetriphosphate

Biochimica et Biophysica Acta (BBA) - General Subjects ◽

10.1016/0304-4165(67)90128-6 ◽

1967 ◽

Vol 148 (2) ◽

pp. 335-341 ◽

Cited By ~ 17

Author(s):

James B. Walker ◽

Margaret S. Walker

Keyword(s):

Enzymatic Synthesis ◽

Streptomycin Biosynthesis

Evidence for participation of a phosphorylated derivative of streptidine in streptomycin biosynthesis

Biochimica et Biophysica Acta (BBA) - General Subjects ◽

10.1016/0304-4165(65)90122-4 ◽

1965 ◽

Vol 97 (2) ◽

pp. 397-398 ◽

Cited By ~ 9

Author(s):

Margaret S. Walker ◽

James B. Walker

Keyword(s):

Streptomycin Biosynthesis

Crystal Structure ofl-Arginine:Inosamine-Phosphate Amidinotransferase StrB1 fromStreptomycesgriseus: An Enzyme Involved in Streptomycin Biosynthesis‡

Biochemistry ◽

10.1021/bi981949p ◽

1998 ◽

Vol 37 (51) ◽

pp. 17664-17672 ◽

Cited By ~ 29

Author(s):

Erich Fritsche ◽

Andreas Bergner ◽

Andreas Humm ◽

Wolfgang Piepersberg ◽

Robert Huber

Keyword(s):

Crystal Structure ◽

Streptomycin Biosynthesis

Transfer of Streptomycin Biosynthesis Gene Clusters within Streptomycetes Isolated from Soil

Applied and Environmental Microbiology ◽

10.1128/aem.64.12.5061-5063.1998 ◽

1998 ◽

Vol 64 (12) ◽

pp. 5061-5063 ◽

Cited By ~ 33

Author(s):

Sharon Egan ◽

Pamela Wiener ◽

Dimitrios Kallifidas ◽

Elizabeth M. H. Wellington

Keyword(s):

Gene Transfer ◽

Gene Clusters ◽

Transfer Event ◽

Streptomycin Biosynthesis ◽

Biosynthesis Gene

ABSTRACT Streptomyces strains isolated from soil were found to possess various numbers of genes from the streptomycin biosynthesis cluster. The strains missing genes from the cluster also lacked the ability to produce streptomycin. Two of the isolates which contain only part of the cluster are apparently recipients of a gene transfer event. The implications for the role of gene transfer in antibiotic evolution are discussed.

The effect of inorganic phosphate on cyclic adenosine 3′, 5′-monophosphate in streptomycin-producing cultures of Streptomyces griseus

Canadian Journal of Microbiology ◽

10.1139/m81-162 ◽

1981 ◽

Vol 27 (10) ◽

pp. 1044-1047 ◽

Cited By ~ 7

Author(s):

J. Terry ◽

D. G. Springham

Keyword(s):

Cyclic Amp ◽

Inorganic Phosphate ◽

Streptomyces Griseus ◽

Phosphate Concentration ◽

Concentration Addition ◽

Defined Media ◽

Streptomycin Biosynthesis

Intracellular and extracellular cyclic adenosine 3′, 5′-monophosphate (cyclic AMP) levels were measured during the growth of a streptomycin-producing strain of Streptomyces griseus. Increasing the inorganic phosphate concentration of the defined media resulted in a decreased streptomycin titre and alterations in the magnitude and timing of changes in cyclic AMP concentration. Addition of excess inorganic phosphate after 24 h of growth reduced steptomycin production but had no effect on the intracellular cyclic AMP concentration. The results do not suggest that the effect of inorganic phosphate on streptomycin biosynthesis is mediated by cyclic AMP.