Unit activity in an epileptic focus formed in the cat motor cortex with tetanus toxin

1979 ◽  
Vol 10 (6) ◽  
pp. 425-431
Author(s):  
G. N. Kryzhanovskii ◽  
V. M. Okudzhava ◽  
M. B. Rekhtman ◽  
I. A. Mzhaviya
Keyword(s):  
Motor Cortex ◽  
Unit Activity ◽  
Tetanus Toxin ◽  
Epileptic Focus

scholarly journals Locally Applied Valproate Enhances Survival in Rats after Neocortical Treatment with Tetanus Toxin and Cobalt Chloride

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Dirk-Matthias Altenmüller ◽  
Jonas M. Hebel ◽  
Michael P. Rassner ◽  
Silvanie Volz ◽  
Thomas M. Freiman ◽  
...  
Keyword(s):  
Tetanus Toxin ◽  
Cobalt Chloride ◽  
Local Application ◽  
Controlled Study ◽  
Epileptic Focus ◽  
Depth Electrodes ◽  
Spontaneous Seizures ◽  
Neocortical Epilepsy ◽  
The Right ◽  
Therapy Strategies

Purpose. In neocortical epilepsies not satisfactorily responsive to systemic antiepileptic drug therapy, local application of antiepileptic agents onto the epileptic focus may enhance treatment efficacy and tolerability. We describe the effects of focally applied valproate (VPA) in a newly emerging rat model of neocortical epilepsy induced by tetanus toxin (TeT) plus cobalt chloride (CoCl2).Methods. In rats, VPA (n=5) or sodium chloride (NaCl) (n=5) containing polycaprolactone (PCL) implants were applied onto the right motor cortex treated before with a triple injection of 75 ng TeT plus 15 mg CoCl2. Video-EEG monitoring was performed with intracortical depth electrodes.Results. All rats randomized to the NaCl group died within one week after surgery. In contrast, the rats treated with local VPA survived significantly longer (P<0.01). In both groups, witnessed deaths occurred in the context of seizures. At least3/4of the rats surviving the first postoperative day developed neocortical epilepsy with recurrent spontaneous seizures.Conclusions. The novel TeT/CoCl2approach targets at a new model of neocortical epilepsy in rats and allows the investigation of local epilepsy therapy strategies. In this vehicle-controlled study, local application of VPA significantly enhanced survival in rats, possibly by focal antiepileptic or antiepileptogenic mechanisms.

Unit activity of motor cortex during acoustically signalled reaching in rats

1984 ◽  
Vol 12 (3) ◽  
pp. 317-326 ◽  
Author(s):  
V.M. Storozhuk ◽  
V. Brácha ◽  
G. Brožek ◽  
J. Bureš
Keyword(s):  
Motor Cortex ◽  
Unit Activity

Skilled forelimb movements and unit activity in motor cortex and caudate nucleus in rats

Neuroscience ◽  
1977 ◽  
Vol 2 (1) ◽  
pp. 73-80 ◽  
Author(s):  
E. Dolbakyan ◽  
N. Hernandez-Mesa ◽  
J. Buresˇ
Keyword(s):  
Motor Cortex ◽  
Caudate Nucleus ◽  
Unit Activity ◽  
Forelimb Movements

scholarly journals Single-unit activity, threshold crossings, and local field potentials in motor cortex differentially encode reach kinematics

2015 ◽  
Vol 114 (3) ◽  
pp. 1500-1512 ◽  
Author(s):  
Sagi Perel ◽  
Patrick T. Sadtler ◽  
Emily R. Oby ◽  
Stephen I. Ryu ◽  
Elizabeth C. Tyler-Kabara ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Local Field ◽  
Unit Activity ◽  
Single Unit ◽  
Primary Motor Cortex ◽  
Spatial Scales ◽  
Local Field Potentials ◽  
Single Unit Activity ◽  
Field Potentials ◽  
Threshold Crossing

A diversity of signals can be recorded with extracellular electrodes. It remains unclear whether different signal types convey similar or different information and whether they capture the same or different underlying neural phenomena. Some researchers focus on spiking activity, while others examine local field potentials, and still others posit that these are fundamentally the same signals. We examined the similarities and differences in the information contained in four signal types recorded simultaneously from multielectrode arrays implanted in primary motor cortex: well-isolated action potentials from putative single units, multiunit threshold crossings, and local field potentials (LFPs) at two distinct frequency bands. We quantified the tuning of these signal types to kinematic parameters of reaching movements. We found 1) threshold crossing activity is not a proxy for single-unit activity; 2) when examined on individual electrodes, threshold crossing activity more closely resembles LFP activity at frequencies between 100 and 300 Hz than it does single-unit activity; 3) when examined across multiple electrodes, threshold crossing activity and LFP integrate neural activity at different spatial scales; and 4) LFP power in the “beta band” (between 10 and 40 Hz) is a reliable indicator of movement onset but does not encode kinematic features on an instant-by-instant basis. These results show that the diverse signals recorded from extracellular electrodes provide somewhat distinct and complementary information. It may be that these signal types arise from biological phenomena that are partially distinct. These results also have practical implications for harnessing richer signals to improve brain-machine interface control.

Effects of GABAB antagonists on transcallosal responses of unit activity recorded in the cat motor cortex

1994 ◽  
Vol 19 ◽  
pp. S188
Author(s):  
Md Syed Ahsan Chowdhury ◽  
Takashi Kawashima ◽  
Tokitaka Konishi ◽  
Ken'ichi Matsunami
Keyword(s):  
Motor Cortex ◽  
Unit Activity ◽  
Gabab Antagonists

Changes in single unit activity in the cat senso motor cortex during repetitive stimulation

1976 ◽  
Vol 7 (4) ◽  
pp. 340-342
Author(s):  
A. A. Pirogov
Keyword(s):  
Motor Cortex ◽  
Unit Activity ◽  
Single Unit ◽  
Repetitive Stimulation ◽  
Single Unit Activity

Statistical analysis of unit activity in the cat motor cortex

1980 ◽  
Vol 11 (3) ◽  
pp. 145-150
Author(s):  
B. M. Sidorov ◽  
V. V. Shul'govskii ◽  
B. I. Kotlyar
Keyword(s):  
Statistical Analysis ◽  
Motor Cortex ◽  
Unit Activity
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