Laminin and heparan sulphate proteoglycan in the lesioned adult mammalian central nervous system and their possible relationship to axonal sprouting

1988 ◽  
Vol 17 (3) ◽  
pp. 385-397 ◽  
Author(s):  
N. Giftochristos ◽  
S. David
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Heparan Sulphate ◽  
Heparan Sulphate Proteoglycan ◽  
Axonal Sprouting ◽  
Sulphate Proteoglycan ◽  
Mammalian Central Nervous System

Light microscopic immunolocalization of laminin, type IV collagen, nidogen, heparan sulphate proteoglycan and fibronectin in the enteric nervous system of rat and guinea pig

1986 ◽  
Vol 15 (6) ◽  
pp. 733-743 ◽  
Author(s):  
Peter G. C. Bannerman ◽  
Rhona Mirsky ◽  
Kristjàn R. Jessen ◽  
Rupert Timpl ◽  
Victor C. Duance
Keyword(s):  
Nervous System ◽  
Guinea Pig ◽  
Enteric Nervous System ◽  
Type Iv Collagen ◽  
Heparan Sulphate ◽  
Heparan Sulphate Proteoglycan ◽  
Sulphate Proteoglycan ◽  
Type Iv

Mosaic serine proteases in the mammalian central nervous system

10.2741/2818 ◽  
2008 ◽  
Vol 13 (13) ◽  
pp. 1991 ◽  
Author(s):  
Shinichi Mitsui
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Serine Proteases ◽  
Mammalian Central Nervous System

Recent Advances in the Pharmacology of Excitatory Amino Acids in the Mammalian Central Nervous System

Excitotoxins ◽  
1983 ◽  
pp. 43-54 ◽  
Author(s):  
J. Davies ◽  
R. H. Evans ◽  
A. W. Jones ◽  
K. N. Mewett ◽  
D. A. S. Smith ◽  
...  
Keyword(s):  
Amino Acids ◽  
Central Nervous System ◽  
Nervous System ◽  
Excitatory Amino Acids ◽  
Mammalian Central Nervous System ◽  
Recent Advances

Grafting in the mammalian central nervous system

1993 ◽  
Vol 73 (3) ◽  
pp. 583-616 ◽  
Author(s):  
L. J. Fisher ◽  
F. H. Gage
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mammalian Central Nervous System

Function of Catecholamine-containing Neurones in Mammalian Central Nervous System

1972 ◽  
Vol 238 (86) ◽  
pp. 245-246 ◽  
Author(s):  
T. J. CROW ◽  
G. W. ARBUTHNOTT
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mammalian Central Nervous System

Axonal Sprouting and Neuronal Connectivity following Central Nervous System Insult: Implications for Occupational Therapy

2002 ◽  
Vol 65 (10) ◽  
pp. 469-475 ◽  
Author(s):  
Muriel Kelly ◽  
Surya Shah
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Occupational Therapy ◽  
Critical Analysis ◽  
Treatment Strategies ◽  
Axonal Sprouting ◽  
Motor Tasks ◽  
Collateral Sprouting ◽  
Therapy Interventions ◽  
Occupational Therapy Interventions

Based on selected contemporary research, this paper presents a critical analysis of central nervous system (CNS) reorganisation following insult and the need for therapists better to understand the processes that constitute reorganisation and their possible contribution to the development of spasticity. In the treatment of the sequelae of CNS lesions, the synaptic reorganisation as a result of losses caused by injury - in the form of axonal sprouting - is illustrated, focusing on neuronal reconnectivity. Critical analysis of laboratory, electron microscopy and other animal and human studies is also conducted to integrate the controversies identified and to highlight the concepts that become relevant for occupational therapists, in order to optimise therapeutic intervention for maximising restitution in patients with CNS insult. The paper further discusses the capacity of the CNS to compensate and the need to utilise occupational therapy interventions, such as imagining, mental rehearsals, constraint-induced therapy, virtual reality, biofeedback and the traditional repetitive tasks, which leads to ensuring and facilitating the emergence of new synapses to perform motor tasks and manual skills and to prevent secondary changes. These external stimulations provided by the therapists are likely to stimulate both the damaged hemisphere cross-innervation and/or collateral sprouting. These scientifically based treatment strategies and neurological rehabilitation programmes would, in turn, contribute to improving the quality of life of people with CNS insult.

Sign in / Sign up

Export Citation Format

Share Document