Chemosensitivity of head and neck squamous carcinoma cell lines is not primarily correlated with glutathione level but is modified by glutathione depletion

1996 ◽  
Vol 122 (11) ◽  
pp. 653-658 ◽  
Author(s):  
Henning Bier ◽  
Thomas Hoffmann ◽  
Peter Eickelmann ◽  
Dieter Hafner
Keyword(s):  
Head And Neck ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Squamous Carcinoma ◽  
Glutathione Depletion ◽  
Glutathione Level ◽  
Carcinoma Cell Lines ◽  
Squamous Carcinoma Cell

Non-steroidal anti-inflammatory drugs inhibit telomerase activity in head and neck squamous carcinoma cell lines

Head & Neck ◽  
2001 ◽  
Vol 23 (12) ◽  
pp. 1049-1055 ◽  
Author(s):  
Dietmar Thurnher ◽  
Maia Bakroeva ◽  
Michael Formanek ◽  
Birgit Knerer ◽  
Johannes Kornfehl
Keyword(s):  
Head And Neck ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Squamous Carcinoma ◽  
Telomerase Activity ◽  
Carcinoma Cell Lines ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Squamous Carcinoma Cell

Relationship of glutathione and glutathione-S-transferase to cisplatin sensitivity in human head and neck squamous carcinoma cell lines

1994 ◽  
Vol 85 (2) ◽  
pp. 223-232 ◽  
Author(s):  
Seth A. Yellin ◽  
Bruce J. Davidson ◽  
John T. Pinto ◽  
Peter G. Sacks ◽  
Changhong Qiao ◽  
...  
Keyword(s):  
Head And Neck ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Squamous Carcinoma ◽  
Human Head ◽  
Glutathione S Transferase ◽  
Carcinoma Cell Lines ◽  
Cisplatin Sensitivity ◽  
Squamous Carcinoma Cell ◽  
Relationship Of

scholarly journals The antitumor drug F14512 enhances cisplatin and ionizing radiation effects in head and neck squamous carcinoma cell lines

Oral Oncology ◽  
2014 ◽  
Vol 50 (2) ◽  
pp. 113-119 ◽  
Author(s):  
F. Mouawad ◽  
A. Gros ◽  
B. Rysman ◽  
C. Bal-Mahieu ◽  
C. Bertheau ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Head And Neck ◽  
Cell Lines ◽  
Radiation Effects ◽  
Carcinoma Cell ◽  
Squamous Carcinoma ◽  
Antitumor Drug ◽  
Carcinoma Cell Lines ◽  
Squamous Carcinoma Cell

Fenretinide-induced apoptosis of human head and neck squamous carcinoma cell lines☆☆☆★★★

1998 ◽  
Vol 118 (4) ◽  
pp. 464-471 ◽  
Author(s):  
RICHARD L. SCHER ◽  
WILFRED SAITO ◽  
RICHARD K. DODGE ◽  
WILLIAM J. RICHTSMEIER ◽  
ROBERT L. FINE
Keyword(s):  
Head And Neck ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Squamous Carcinoma ◽  
Human Head ◽  
Carcinoma Cell Lines ◽  
Squamous Carcinoma Cell ◽  
Induced Apoptosis

Multiparametric Flow Cytometry of Human Squamous Cell Carcinoma Lines from the Head and Neck

1988 ◽  
Vol 98 (6) ◽  
pp. 552-557 ◽  
Author(s):  
Thomas P.U. Wustrow ◽  
Alexander Raffael ◽  
Günter Valet
Keyword(s):  
Drug Resistance ◽  
Head And Neck ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Squamous Carcinoma ◽  
Cytotoxic Drug ◽  
Chemotherapeutic Drugs ◽  
Carcinoma Cell Lines ◽  
Squamous Carcinoma Cell

Squamous cell carcinomas of the head and neck consist of heterogeneous cell populations. The purpose of the present study was to Investigate whether established cell lines from human head and neck cancers under chemotherapy behaved similarly to tumors in patients during in vivo treatment. This Is of Interest in terms of improvements of chemotherapeutic protocols and understanding of the mechanisms of cytotoxic drug resistance. Permanent squamous carcinoma cell lines of the larynx (HLaC 78, 79), parotid gland (HPaC 79), tongue (SCC-15, SCC-25), hypopharynx (FaDu), and tumor lines with different histology and origin, as mucoepidermoid cancer cells of the submandibular gland (A 253), Epstein-Barr virus-infected human B cells (BC-1) and mouse fibroblasts (3T3) were Incubated with chemotherapeutic drugs for 1 to 4 days at 37° C. Despite the microscopic similarities to patient carcinomas, cancer cell lines of the head and neck showed different susceptibilities to cell kill mediated by chemotherapeutic drugs, as compared to in vivo therapeutic results with patients. The nonsquamous carcinoma lines demonstrated high chemosensitive responses after incubation with daunorubicin, cyclophosphamide, dactinomycin, vincristine, and aclarubicin. Surprisingly, only low cell killing rates in squamous carcinoma cell lines were observed after incubation with chemotherapeutic agents such as cis-platinum, 5-fluorouracil, methotrexate, or bleomycin, which are most commonly used for head and neck cancers. The results show that cytotoxic drug action on in vitro cultured squamous carcinoma cell lines of the head and neck is not representative for the in vivo responses of patient tumors. The cell lines are, however, of potential value for evaluation of cell biochemical changes associated with cytotoxic drug resistance.

scholarly journals E1A-mediated suppression of EGFR expression and induction of apoptosis in head and neck squamous carcinoma cell lines

Oncogene ◽  
2003 ◽  
Vol 22 (13) ◽  
pp. 1965-1977 ◽  
Author(s):  
Marcella Flinterman ◽  
Joop Gäken ◽  
Farzin Farzaneh ◽  
Mahvash Tavassoli
Keyword(s):  
Head And Neck ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Squamous Carcinoma ◽  
Carcinoma Cell Lines ◽  
Egfr Expression ◽  
Induction Of Apoptosis ◽  
Squamous Carcinoma Cell

scholarly journals Macromolecular osteolytic factor synthesised by squamous carcinoma cell lines from the head and neck in vitro is interleukin 1

1988 ◽  
Vol 58 (1) ◽  
pp. 17-21 ◽  
Author(s):  
S Meghji ◽  
JR Sandy ◽  
AM Scutt ◽  
W Harvey ◽  
RL Carter ◽  
...  
Keyword(s):  
Head And Neck ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Interleukin 1 ◽  
Squamous Carcinoma ◽  
Carcinoma Cell Lines ◽  
Squamous Carcinoma Cell

In vitro activity of novel antifolates against human squamous carcinoma cell lines of the head and neck with inherent resistance to methotrexate

1992 ◽  
Vol 51 (6) ◽  
pp. 909-914 ◽  
Author(s):  
B. F. A. M. van der Laan ◽  
G. Jansen ◽  
G. A. M. Kathmann ◽  
G. R. Westerhof ◽  
J. H. Schornagel ◽  
...  
Keyword(s):  
Head And Neck ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Squamous Carcinoma ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Carcinoma Cell Lines ◽  
Squamous Carcinoma Cell

Abstract 902: XRCC1 induction after cisplatin treatment in head and neck squamous carcinoma cell lines: Evaluation using nanoimmunoassay

2014 ◽  
Author(s):  
Stephen S. Schoeff ◽  
Dane M. Barrett ◽  
James Teng ◽  
Ashraf Khalil ◽  
Matthew A. Hubbard ◽  
...  
Keyword(s):  
Head And Neck ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Squamous Carcinoma ◽  
Carcinoma Cell Lines ◽  
Squamous Carcinoma Cell

Abstract 372: Taselisib enhances the potency of ERBB inhibitors in biomarker-defined subsets of head and neck squamous carcinoma cell lines

2016 ◽  
Author(s):  
Heidi M. Savage ◽  
Carol O’Brien ◽  
Heather Moore ◽  
Mark R. Lackner ◽  
Robert Yauch ◽  
...  
Keyword(s):  
Head And Neck ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Squamous Carcinoma ◽  
Carcinoma Cell Lines ◽  
Squamous Carcinoma Cell
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