Effect of treatment with LHRH analogs containing cytotoxic radicals on the binding characteristics of receptors for luteinizing-hormone-releasing hormone in MXT mouse mammary carcinoma

1993 ◽  
Vol 119 (5) ◽  
pp. 273-278 ◽  
Author(s):  
Slobodan R. Milovanovic ◽  
Elvira Monje ◽  
Karoly Szepeshazi ◽  
Sinisa Radulovic ◽  
Andrew Schally
Keyword(s):  
Luteinizing Hormone ◽  
Mammary Carcinoma ◽  
Mouse Mammary Carcinoma ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Binding Characteristics ◽  
Effect Of Treatment

Effect of luteinizing hormone-releasing hormone analogs containing cytotoxic radicals on growth of estrogen-independent MXT mouse mammary carcinoma in vivo

1992 ◽  
Vol 3 (2) ◽  
pp. 109-116 ◽  
Author(s):  
Karoly Szepeshazi ◽  
Andrew V Schally ◽  
Attila Juhasz ◽  
Attila Nagy ◽  
Tamas Janaky
Keyword(s):  
Luteinizing Hormone ◽  
Mammary Carcinoma ◽  
Mouse Mammary Carcinoma ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Hormone Analogs

Treatment of experimental DMBA induced mammary carcinoma with Cetrorelix (SB-75): a potent antagonist of luteinizing hormone-releasing hormone

1992 ◽  
Vol 118 (1) ◽  
pp. 44-49 ◽  
Author(s):  
Thomas Reissmann ◽  
Peter Hilgard ◽  
Johannes H. Harleman ◽  
J�rgen Engel ◽  
Ana M. Comaru-Schally ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Mammary Carcinoma ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Potent Antagonist

scholarly journals Postmenopause-Like Bone Loss by Mammary Carcinoma Walker256/S Which Secretes Luteinizing Hormone-Releasing Hormone

1999 ◽  
Vol 80 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Yoshihiro Waki ◽  
Ken-ichi Miyamoto ◽  
Shinya Yamamoto ◽  
Yukie Saitoh ◽  
Shohei Kasugai ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Bone Loss ◽  
Mammary Carcinoma ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone

EFFECT OF TREATMENT WITH AN AGONIST OF LUTEINIZING HORMONE RELEASING HORMONE ON EARLY MATURATIONAL CHANGES IN PITUITARY AND TESTICULAR FUNCTION IN THE RAT

1979 ◽  
Vol 80 (2) ◽  
pp. 249-257 ◽  
Author(s):  
R. M. SHARPE ◽  
H. M. FRASER ◽  
J. SANDOW
Keyword(s):  
Luteinizing Hormone ◽  
Serum Concentration ◽  
Male Rats ◽  
Testicular Function ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Testicular Weight ◽  
Effect Of Treatment ◽  
Lh Rh

Male rats aged 30 days were injected once daily for between 1 and 7 days with 50 ng (d-serine t-butyl6, des-glycine-NH210) luteinizing hormone releasing hormone ethylamide (LH-RH agonist), and pituitary and testicular function were assessed. Treatment for 7 days significantly (P < 0·02) inhibited maturational increases in the pituitary content and serum concentration of gonadotrophins, testicular luteinizing hormone (LH)-receptor concentration and the testicular capacity to secrete testosterone; the pituitary content and serum concentration of prolactin, the hypothalamic content of LH-RH and testicular weight were unaffected. In rats treated with LH-RH agonist, the initial (2 to 3 days) reduction in testicular LH-receptors and the capacity to secrete testosterone probably resulted from acutely raised levels of LH in the blood, whilst later effects may have resulted from the apparently chronic reduction in serum gonadotrophin levels. The latter may reflect a decrease in pituitary responsiveness to repeated stimulation with LH-RH agonist. Despite the extensive loss of testicular LH-receptors and diminished responsiveness, the concentration of HCG which significantly (P < 0·05) increased testosterone secretion by the testis in vitro was the same (2 pmol/l) as that for testes from control rats.

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