Control theory of metabolic channelling

Boris N. Kholodenko; Marta Cascante; Hans V. Westerhoff

doi:10.1007/bf01267963

Control theory of metabolic channelling

Molecular and Cellular Biochemistry ◽

10.1007/bf01267963 ◽

1994 ◽

Vol 133-134 (1) ◽

pp. 313-331 ◽

Cited By ~ 15

Author(s):

Boris N. Kholodenko ◽

Marta Cascante ◽

Hans V. Westerhoff

Keyword(s):

Control Theory ◽

Metabolic Channelling

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Control theory of metabolic channelling

Cellular Bioenergetics: Role of Coupled Creatine Kinases ◽

10.1007/978-1-4615-2612-4_21 ◽

1994 ◽

pp. 313-331

Author(s):

Boris N. Kholodenko ◽

Marta Cascante ◽

Hans V. Westerhoff

Keyword(s):

Control Theory ◽

Metabolic Channelling

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CONTROL THEORY OF CELL METABOLISM: TOWARDS MORE REALISTIC “NON-IDEAL” SYSTEMS

Journal of Biological System ◽

10.1142/s0218339095000149 ◽

1995 ◽

Vol 03 (01) ◽

pp. 145-154

Author(s):

B.N. KHOLODENKO ◽

M. CASCANTE ◽

D. MOLENAAR ◽

O.V. DEMIN ◽

A.A. VAN DER GUGTEN ◽

...

Keyword(s):

Control Theory ◽

Metabolic Control ◽

Cell Metabolism ◽

Reaction Cycle ◽

Enzyme Reactions ◽

Metabolic Channelling ◽

High Enzyme ◽

Flux Control Coefficients ◽

Control Coefficients ◽

Complex Cases

Metabolic Control Analyses have led to significant advances in understanding the control of cell metabolism. However, the classical theory does not address all complex cases of the organization of cellular metabolism. Here the control theory is extended to include (i) pathways with high enzyme concentrations and moiety conservation and (ii) metabolic channelling in general. The new theory descends the microlevel of elemental steps into the reaction cycle of the enzymes and turns back to the macrolevel of complete enzyme reactions. We showed how the elemental control coefficients are related to the traditional flux control coefficients of the enzymes. We derived what the sums of the enzyme control coefficients are equal to in various non-ideal cell pathways.

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