Granular cell tumors of the gastrointestinal tract and perianal region A study of 74 cases

Abstract The granular cell tumor is a solitary painless nodule that arises most commonly on the skin or the tongue. The vast majority are benign. Approximately 5% to 9% of granular cell tumors have been reported in the gastrointestinal tract, most commonly in the esophagus. We report a case of a 45-year-old African American woman with multifocal granular cell tumors of the esophagus and proximal stomach. Two lesions within the distal esophagus and proximal stomach were characteristic nodular granular cell tumors. Within the mid esophagus there was poorly defined transmural involvement by benign-appearing granular cells. This pattern of infiltration by benign cells is uncharacteristic. A review of the literature with emphasis on the determination of malignancy is also presented.

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Perianal Granular Cell Tumor: Report of a Case and Review of the Literature

Tumori Journal ◽

10.1177/030089160909500424 ◽

2009 ◽

Vol 95 (4) ◽

pp. 538-541 ◽

Cited By ~ 6

Author(s):

Massimiliano Mistrangelo ◽

Paola Cassoni ◽

Gitana Scozzari ◽

Isabella Castellano ◽

Giorgia Gavello ◽

...

Keyword(s):

Literature Search ◽

Granular Cell Tumor ◽

Clinical Course ◽

Granular Cell ◽

Surgical Excision ◽

Cell Tumor ◽

Pathological Examination ◽

Perianal Region ◽

Therapeutic Procedures

Introduction Granular cell tumor was first described by Abrikossoff in 1926. Over the years several cases of this neoplasm have been reported, with a variety of localizations. We here report a case of perianal granular cell tumor and discuss its histogenesis and its relevance to clinical practice. Methods The clinical course and histopathology of the case are reviewed, and a literature search for other reported cases has been performed. Results A 46-year-old woman presented with a perianal nodular lesion. Pathological examination revealed a granular cell tumor. A literature search produced only 25 other cases of anal and perianal granular cell tumors. Conclusions Granular cell tumors are rarely observed in the perianal region. Their existence must always be borne in mind in the differential diagnosis of perianal neoplasms. In most cases surgical excision is curative, but potential malignant transformation must be considered during therapeutic procedures and follow-up.

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Multiple Metachronous Granular Cell Tumors of the Gastrointestinal Tract within a Single Patient: a Case Report and Review of the Literature

Cancer and Oncology Research ◽

10.13189/cor.2013.010205 ◽

2013 ◽

Vol 1 (2) ◽

pp. 52-54

Author(s):

Jeffrey M. Sutton MD ◽

Jonathan Tobias MD ◽

Ian M. Paquette MD

Keyword(s):

Case Report ◽

Gastrointestinal Tract ◽

Granular Cell ◽

Review Of The Literature ◽

Single Patient

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Premalignant and Malignant Perianal Lesions

Clinics in Colon and Rectal Surgery ◽

10.1055/s-0039-1687835 ◽

2019 ◽

Vol 32 (05) ◽

pp. 386-393

Author(s):

Mohammad Ali Abbass ◽

Michael A. Valente

Keyword(s):

Gastrointestinal Tract ◽

Treatment Options ◽

Disease Process ◽

Perianal Skin ◽

Precursor Lesions ◽

Perianal Region ◽

Treatment Delays ◽

Impact On Survival ◽

Missed Diagnosis ◽

Malignant Lesions

AbstractAnal cancer is a heterogeneous and rare disease process that accounts for ∼1.5% of all gastrointestinal tract malignancies. The perianal skin plays host to a variety of different premalignant and malignant lesions, all with variable histology, treatment options, and prognosis. Anal cancers in general are notorious for having a delayed or missed diagnosis leading to treatment delays and may have an impact on survival. This delay is in part due to the nonspecific symptomatology and also improper physical examination of the sensitive and anatomically complex perianal region and anal canal. This article examines the various types of perianal cancers and their precursor lesions and will explore treatment options as well as outcomes and prognosis.

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Multifocal granular cell tumors of the gastrointestinal tract: Immunohistochemical findings compared with those of solitary tumors

Pathology International ◽

10.1111/j.1440-1827.2004.01579.x ◽

2004 ◽

Vol 54 (1) ◽

pp. 47-51 ◽

Cited By ~ 7

Author(s):

Hiroyuki Mitomi ◽

Yutaka Matsumoto ◽

Akio Mori ◽

Nobuyasu Arai ◽

Keita Ishii ◽

...

Keyword(s):

Gastrointestinal Tract ◽

Granular Cell

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Recurrent granular cell tumor of the anal–perianal region: how much anal sphincter can be resected?

Techniques in Coloproctology ◽

10.1007/s10151-013-1043-6 ◽

2013 ◽

Vol 18 (6) ◽

pp. 597-600 ◽

Cited By ~ 2

Author(s):

X. Y. Wan ◽

B. Hu ◽

Z. Y. Zhou ◽

Y. Huang ◽

D. L. Ren

Keyword(s):

Anal Sphincter ◽

Granular Cell Tumor ◽

Granular Cell ◽

Cell Tumor ◽

Perianal Region

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Rare case of granular cell tumor of perianal region: a case report and literature review

Journal of International Medical Research ◽

10.1177/0300060520982689 ◽

2021 ◽

Vol 49 (1) ◽

pp. 030006052098268

Author(s):

Jianhua Ma ◽

Yicheng Cheng ◽

Xue Li ◽

Wei Liu ◽

Renghai Liu ◽

...

Keyword(s):

Granular Cell Tumor ◽

Immunohistochemical Analysis ◽

Granular Cell ◽

Cell Tumor ◽

Accurate Diagnosis ◽

Perianal Region ◽

Appropriate Treatment ◽

Anal Neoplasm ◽

Clinical Complaint

Granular cell tumors (GCTs) are rare submucosal neoplasms, with tumors in the oral mucosa accounting for about a third of all cases. In contrast, GCT is a rare anal neoplasm, with fewer than 30 cases of perianal GCT reported in the literature. We report the case of a 36-year-old woman with a perianal lump with no obvious local lesion as the main clinical complaint. The tumor was completely resected and histologically confirmed as a GCT. The patient remained under continuous follow-up. GCT is difficult for surgeons and pathologists to diagnose, and biopsy and immunohistochemical analysis are prerequisites for an accurate diagnosis. An integrated understanding of GCT in terms of its differential diagnosis will contribute to better identification and more appropriate treatment of this disease.

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Granular Cell Tumor of Rectum: A Very Rare Entity

Case Reports in Gastrointestinal Medicine ◽

10.1155/2017/3795482 ◽

2017 ◽

Vol 2017 ◽

pp. 1-3 ◽

Cited By ~ 3

Author(s):

Tagore Sunkara ◽

Savitha V. Nagaraj ◽

Vinaya Gaduputi

Keyword(s):

Gastrointestinal Tract ◽

Curative Resection ◽

Granular Cell Tumor ◽

Granular Cell ◽

Cell Tumor ◽

Rare Entity

Granular cell tumors are predominantly benign, occurring more commonly in women, with about 10% developing in the gastrointestinal tract. Rectal location of this tumor is very rare. We herein report one such case of a 61-year-old man with granular cell tumor in the rectum who underwent endoscopic curative resection.

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