Use of the edge effect arising during heating of the end of a cylinder for comparative determination of the heat resistance of brittle material

1972 ◽  
Vol 4 (3) ◽  
pp. 309-315 ◽  
Author(s):  
O. V. Minin ◽  
N. A. Yaryshev
1969 ◽  
Vol 1 (3) ◽  
pp. 258-263
Author(s):  
G. S. Pisarenko ◽  
G. A. Gogotsi ◽  
V. M. Antonenko ◽  
I. I. Nemets ◽  
G. B. Dobrovol'skii

2015 ◽  
Vol 66 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Suzana Žunec ◽  
Božica Radić ◽  
Kamil Kuča ◽  
Kamil Musilek ◽  
Ana Lucić Vrdoljak

Abstract The inability of standard therapy to provide adequate protection against poisoning by organophosphorus compounds (pesticides and nerve agents) motivated us to search for new, more effective oximes. We investigated the pharmacotoxicological properties of six experimental K-oximes (K027, K033, K048, K074, K075, and K203) in vivo. The therapeutic efficacy of K-oximes (at doses of 5 or 25 % of their LD50) combined with atropine was assessed in paraoxon-poisoned mice and compared with conventionally used oximes HI-6 and TMB-4. The bisoxime K074 was the most toxic (LD50=21.4 mg kg-1) to mice, while monoxime K027 was the least toxic (LD50=672.8 mg kg-1). With the exception of K033, all of the tested K-oximes showed better therapeutic efficiency than HI-6 and TMB-4. K027 and K048 stood out by demonstrating low acute toxicities and ensuring protective indices ranging from 60.0 to 100.0 LD50 of paraoxon. Taking into account that these two oximes showed a similar therapeutic efficacy regardless of the applied doses, our results suggest that K027 and K048 could be antidotes for paraoxon intoxication.


1992 ◽  
Vol 31 (Part 1, No. 5A) ◽  
pp. 1403-1404
Author(s):  
Hajime Tomokage ◽  
Hidefumi Kamibayashi ◽  
Tokuo Miyamoto

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