scholarly journals Comparative determination of chlorpromazine hydrochloride content in multi-sourced chlorpromazine tablets in Nigeria

2010 ◽  
Vol 1 (1) ◽  
Author(s):  
H Okeri ◽  
P Alonge ◽  
E Etareri
Keyword(s):  
Chlorpromazine Hydrochloride ◽  
Comparative Determination

scholarly journals Comparative determination of the efficacy of bispyridinium oximes in paraoxon poisoning / Usporedno određivanje učinkovitosti bispiridinijevih oksima pri trovanju paraoksonom

2015 ◽  
Vol 66 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Suzana Žunec ◽  
Božica Radić ◽  
Kamil Kuča ◽  
Kamil Musilek ◽  
Ana Lucić Vrdoljak
Keyword(s):  
Therapeutic Efficacy ◽  
Standard Therapy ◽  
Organophosphorus Compounds ◽  
Nerve Agents ◽  
Therapeutic Efficiency ◽  
Hi 6 ◽  
Comparative Determination

Abstract The inability of standard therapy to provide adequate protection against poisoning by organophosphorus compounds (pesticides and nerve agents) motivated us to search for new, more effective oximes. We investigated the pharmacotoxicological properties of six experimental K-oximes (K027, K033, K048, K074, K075, and K203) in vivo. The therapeutic efficacy of K-oximes (at doses of 5 or 25 % of their LD50) combined with atropine was assessed in paraoxon-poisoned mice and compared with conventionally used oximes HI-6 and TMB-4. The bisoxime K074 was the most toxic (LD50=21.4 mg kg-1) to mice, while monoxime K027 was the least toxic (LD50=672.8 mg kg-1). With the exception of K033, all of the tested K-oximes showed better therapeutic efficiency than HI-6 and TMB-4. K027 and K048 stood out by demonstrating low acute toxicities and ensuring protective indices ranging from 60.0 to 100.0 LD50 of paraoxon. Taking into account that these two oximes showed a similar therapeutic efficacy regardless of the applied doses, our results suggest that K027 and K048 could be antidotes for paraoxon intoxication.

Spectrophotometric Determination of Chlorpromazine Hydrochloride Using 4-Nitroanilline by Oxidative Coupling Reaction

2019 ◽  
Vol 16 (1(Suppl.)) ◽  
pp. 0194
Author(s):  
Al-rashidy Et al.
Keyword(s):  
Oxidative Coupling ◽  
Analytical Data ◽  
Reaction Medium ◽  
Coupling Reaction ◽  
Suggested Method ◽  
Sensitivity Index ◽  
Chlorpromazine Hydrochloride ◽  
Oxidative Coupling Reaction ◽  
Relative Standard

A simple, rapid spectrophotometric method has been established for the determination of chlorpromazine hydrochloride (CPZ) in its pure form and in a tablet formulations. The  suggested  method  is  based  on  the  oxidative coupling  reaction  with4-nitroainlline using KIO3 in acidic solution to produce a violet colored product with maximum absorption at λ=526 nm.The  analytical data  obtained  throughout  this  study  could  be  summarid  as  follows:  1ml of 1M HCl (pH=2.2), 1 ml  of  4-nitroanilline (1x10-2M), and 1.5ml  of (1x10-2)KIO3 per 25 ml reaction medium. The order of additions, coupling reaction time, and temperature in addition to the type of solvent were studied. The Beer′s law is obeyed over the concentration range of(5–40) µg ml-1, but the detection limit and quantification limit are 0.34 besides 1.03 µg ml-1 respectively. The correlation coefficient (r) for the calibration graph was found to be 0.9980, molar absorptivity of 10. 25 × 103 L.mol -1.cm-1, and Sandell′s sensitivity index of 0.03467 µg.cm-2. The precision and accuracy of the method were tested by calculating the percentage of relative standard deviation (RSD%) (<1.831%) and the average recovery percent (99.22%) average error percent Erel%(0.558). Direct and standard addition procedures were applied to both standards and specimens of pharmaceutical and the results indicate that the suggested method was successfully applied for the determination of CPZ.

Fabrication of chemically and in situ modified carbon paste electrodes for the potentiometric determination of chlorpromazine HCl in pure pharmaceutical preparations, urine and serum

2017 ◽  
Vol 41 (24) ◽  
pp. 15612-15624 ◽  
Author(s):  
Gehad G. Mohamed ◽  
Eman Y. Z. Frag ◽  
M. A. Zayed ◽  
M. M. Omar ◽  
Sally E. A. Elashery
Keyword(s):  
Biological Fluids ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Carbon Paste ◽  
Chlorpromazine Hydrochloride ◽  
Carbon Paste Electrodes ◽  
Urine And Serum ◽  
Modified Carbon Paste Electrodes

Newly developed modified and in situ modified carbon paste sensors were developed for the determination of chlorpromazine hydrochloride (CPZHC) in pharmaceutical formulations and biological fluids (urine and serum).

scholarly journals On the power of penetrating into space by telescopes; with a comparative determination of the extent of that power in natural vision, and in telescopes of various sizes and constructions; illustrated by select observations

1832 ◽  
Vol 1 ◽  
pp. 5-7
Keyword(s):  
Optic Nerve ◽  
Optical Instrument ◽  
Distant Star ◽  
Naked Eye ◽  
Natural Vision ◽  
Luminous Objects ◽  
Comparative Determination ◽  
Made In

It has long been observed that the power of distinguishing objects at great distances depends not only on the magnifying power applied to the telescope through which they are viewed, but also on the quantity of light emitted by the object, and collected and conveyed to the eye by means of the instrument. The superiority of telescopes with large apertures must hence appear obvious; and we have long witnessed the essential improvements made in this respect by Dr. Herschel, which have enabled him to extend his view into the firmament to distances, the bare mention of which is sufficient to astonish a mind unaccustomed to investigations of this nature. That it is principally the increased quantity of light that enables us to view luminous objects at great distances will appear manifest if we reflect that, since the density of light decreases in the ratio of the squares of the distances of the objects emitting the light, it follows that an object may be removed to distances at which its light will be so rarefied as to produce no longer any sensation upon the optic nerve: that if an optical instrument be used with an object-glass of a larger diameter than the pupil of the eye, the quantity of light collected by this means in the eye will be greater in proportion to the greater extent of the object-glass compared with that of the pupil: and that hence the most distant star that can be seen with the naked eye, if it be viewed through a tube with an object-glass of twice the diameter of the pupil, it will without any magnifying power be visible at a distance four times greater than that at which the naked eye ceased to perceive it. Dr. Herschel many years ago adverted to this circumstance, when in his paper on the Construction of the Heavens, he introduced what he then figuratively called his sounding line , to which he now substitutes the appellation of the power of penetrating into space . And in the present paper he fully investigates a comparative determination of the extent of that power in natural vision, and in telescopes of various sizes and constructions; all which he illustrates by a number of select and curious observations.

Comparative determination of riboflavin in milk by HPLC and lumiflavin methods

Nahrung/Food ◽  
1987 ◽  
Vol 31 (1) ◽  
pp. 77-79 ◽  
Author(s):  
F. Ribarova ◽  
S. Shishkov ◽  
N. Obretenova ◽  
L. Metchkueva
Keyword(s):  
Comparative Determination
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