Prognostic significance of p53 expression in relation to DNA ploidy in colorectal adenocarcinoma

1993 ◽  
Vol 423 (6) ◽  
pp. 443-448 ◽  
Author(s):  
Xiao-Feng Sun ◽  
John M. Carstensen ◽  
Olle Stål ◽  
Hong Zhang ◽  
Erik Nilsson ◽  
...  
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Dna Ploidy ◽  
Prognostic Significance ◽  
P53 Expression

Prognostic Significance of p53 Expression, Chromosome 17 Copy Number, and DNA Ploidy in Non-Metastasized Colorectal Carcinomas (Stages IB and II)

1996 ◽  
Vol 31 (5) ◽  
pp. 481-489 ◽  
Author(s):  
G. B. Baretton ◽  
M. Vogt ◽  
C. Müller ◽  
J. Diebold ◽  
K. Schneiderbanger ◽  
...  
Keyword(s):  
Copy Number ◽  
Dna Ploidy ◽  
Prognostic Significance ◽  
Chromosome 17 ◽  
Colorectal Carcinomas ◽  
P53 Expression

scholarly journals Prognostic significance of the DNA ploidy of the early glottic cancer.

1990 ◽  
Vol 93 (8) ◽  
pp. 1171-1178 ◽  
Author(s):  
NORIO YASUDA ◽  
ATSUKO OMORI ◽  
TATSUYA GOTO ◽  
YASUO HISA ◽  
YASUSHI MURAKAMI ◽  
...  
Keyword(s):  
Dna Ploidy ◽  
Prognostic Significance ◽  
Glottic Cancer ◽  
Early Glottic Cancer

scholarly journals Lack of prognostic significance of DNA ploidy and S phase fraction in breast cancer

1992 ◽  
Vol 66 (5) ◽  
pp. 925-929 ◽  
Author(s):  
PD Stanton ◽  
TG Cooke ◽  
SJ Oakes ◽  
J Winstanley ◽  
S Holt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Ploidy ◽  
Prognostic Significance ◽  
S Phase ◽  
Phase Fraction

scholarly journals Prognostic significance of DNA ploidy and proliferation in 309 colorectal carcinomas as determined by two-color multiparametric DNA flow cytometry

Cancer ◽  
1997 ◽  
Vol 79 (11) ◽  
pp. 2073-2086 ◽  
Author(s):  
Richard J. Zarbo ◽  
Raouf E. Nakhleh ◽  
Ronald D. Brown, James J. Kubus, Ch Ma ◽  
Patricia Mackowiak
Keyword(s):  
Flow Cytometry ◽  
Dna Ploidy ◽  
Prognostic Significance ◽  
Dna Flow Cytometry ◽  
Colorectal Carcinomas

Prognostic significance of DNA ploidy in patients with stage II colorectal cancer

2001 ◽  
Vol 13 (1) ◽  
pp. 53-56
Author(s):  
Hong-yi Wang ◽  
Shan Jin ◽  
Zhong-qi Xue ◽  
Jin Gu ◽  
You-yong Lu
Keyword(s):  
Colorectal Cancer ◽  
Dna Ploidy ◽  
Prognostic Significance ◽  
Stage Ii ◽  
Stage Ii Colorectal Cancer

scholarly journals p53 Expression in Colorectal Cancer:Relation to Tumor Type, DNA Ploidy Pattern, and Short-Term Survival

1996 ◽  
Vol 105 (5) ◽  
pp. 604-612 ◽  
Author(s):  
Giovanni Lanza ◽  
Iva Maestri ◽  
Alessandra Dubini ◽  
Roberta Gafa′ ◽  
Alessandra Santini ◽  
...  
Keyword(s):  
Dna Ploidy ◽  
Tumor Type ◽  
Short Term ◽  
Dna Ploidy Pattern ◽  
Term Survival ◽  
P53 Expression ◽  
Ploidy Pattern ◽  
Short Term Survival

The prognostic significance of DNA ploidy for neuroblastoma

Surgery Today ◽  
1993 ◽  
Vol 23 (3) ◽  
pp. 215-219 ◽  
Author(s):  
Makoto Nakazawa
Keyword(s):  
Dna Ploidy ◽  
Prognostic Significance

High microRNA-28-5p expression in colorectal adenocarcinoma predicts short-term relapse of node-negative patients and poor overall survival of patients with non-metastatic disease

2018 ◽  
Vol 56 (6) ◽  
pp. 990-1000 ◽  
Author(s):  
Panagiotis Tsiakanikas ◽  
Christos K. Kontos ◽  
Dimitrios Kerimis ◽  
Iordanis N. Papadopoulos ◽  
Andreas Scorilas
Keyword(s):  
Overall Survival ◽  
Reverse Transcription ◽  
Colorectal Adenocarcinoma ◽  
Quantitative Polymerase Chain Reaction ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Colorectal Tumors ◽  
Mesenchymal Transition ◽  
Cox Regression Analysis ◽  
Total Rna

Abstract Background: MicroRNAs (miRNAs) may function either as oncogenes or tumor suppressors and are heavily involved in the initiation and progression of cancer, and in metastasis of tumor cells. MicroRNA-28-5p (miR-28-5p) targets several cancer-related genes and is hence involved in cell proliferation, migration, invasion and epithelial-mesenchymal transition. In this study, we investigated the potential diagnostic and prognostic significance of miR-28-5p expression in colorectal adenocarcinoma, the most frequent type of colorectal cancer (CRC). Methods: Therefore, we isolated total RNA from 182 colorectal adenocarcinoma specimens and 86 paired non-cancerous colorectal mucosae. After polyadenylation of 2 μg total RNA and its reverse transcription using an oligo-dT-adapter primer, we quantified miR-28-5p levels using an in-house-developed reverse-transcription real-time quantitative polymerase chain reaction (RT-qPCR) method, based on the SYBR Green chemistry. Results: Comparison of miR-28-5p levels among 86 pairs of colorectal tumors and their adjacent non-cancerous mucosae uncovered the downregulation of miR-28-5p expression in the majority of malignant colorectal tumors. More importantly, high miR-28-5p expression predicts poor disease-free survival (DFS) and overall survival (OS) of colorectal adenocarcinoma patients. Multivariate Cox regression analysis revealed that miR-28-5p overexpression is a significant predictor of poor prognosis in colorectal adenocarcinoma, independent of tumor size, histological grade, TNM staging, radiotherapy and chemotherapy. Interestingly, strong miR-28-5p expression retains its predictive potential regarding relapse among patients with negative regional lymph nodes, and predicts poor OS in patients diagnosed with non-metastatic colorectal adenocarcinoma. Conclusions: High miR-28-5p expression predicts poor DFS and OS of colorectal adenocarcinoma patients, independently of clinicopathological prognosticators and standard patient treatment, including radiotherapy and chemotherapy.

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