Comparative in vitro activity of BAY 12-8039 and five other antimicrobial agents against anaerobic bacteria

1998 ◽  
Vol 17 (3) ◽  
pp. 193-195 ◽  
Author(s):  
C. Edlund ◽  
S. Sabouri ◽  
C. E. Nord
Keyword(s):  
Antimicrobial Agents ◽  
Anaerobic Bacteria ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals In vitro activity of Bay 12-8039, a new 8-methoxyquinolone, compared to the activities of 11 other oral antimicrobial agents against 390 aerobic and anaerobic bacteria isolated from human and animal bite wound skin and soft tissue infections in humans.

1997 ◽  
Vol 41 (7) ◽  
pp. 1552-1557 ◽  
Author(s):  
E J Goldstein ◽  
D M Citron ◽  
M Hudspeth ◽  
S Hunt Gerardo ◽  
C V Merriam
Keyword(s):  
Antimicrobial Agents ◽  
Anaerobic Bacteria ◽  
Fusobacterium Nucleatum ◽  
Vitro Activity ◽  
Penicillin G ◽  
In Vitro Activity ◽  
Bite Wound ◽  
Amoxicillin Clavulanate ◽  
Prevotella Species

The in vitro activity of Bay 12-8039, a new oral 8-methoxyquinolone, was compared to the activities of 11 other oral antimicrobial agents (ciprofloxacin, levofloxacin, ofloxacin, sparfloxacin, azithromycin, clarithromycin, amoxicillin clavulanate, penicillin, cefuroxime, cefpodoxime, and doxycycline) against 250 aerobic and 140 anaerobic bacteria recently isolated from animal and human bite wound infections. Bay 12-8039 was active against all aerobic isolates, both gram-positive and gram-negative isolates, at < or = 1.0 microg/ml (MICs at which 90% of isolates are inhibited [MIC90s < or = 0.25 microg/ml) and was active against most anaerobes at < or = 0.5 microg/ml; the exceptions were Fusobacterium nucleatum and other Fusobacterium species (MIC90s, > or = 4.0 microg/ml) and one strain of Prevotella loeschii (MICs, 2.0 microg/ml). In comparison, the other quinolones tested had similar in vitro activities against the aerobic strains but were less active against the anaerobes, including peptostreptococci, Porphyromonas species, and Prevotella species. The fusobacteria were relatively resistant to all the antimicrobial agents tested except penicillin G (one penicillinase-producing strain of F. nucleatum was found) and amoxicillin clavulanate.

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