Double-blind comparative study of ofloxacin (hoe 280) and trimethoprim-sulfamethoxazole in the treatment of patients with acute exacerbations of chronic bronchitis and chronic obstructive lung disease

Infection ◽  
1991 ◽  
Vol 19 (S7) ◽  
pp. S388-S390 ◽  
Author(s):  
N. P. Boye ◽  
P. Gaustad
Keyword(s):  
Comparative Study ◽  
Lung Disease ◽  
Chronic Bronchitis ◽  
Obstructive Lung Disease ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Double Blind ◽  
Acute Exacerbations

Reversal of Acute Exacerbations of Chronic Obstructive Lung Disease by Inspiratory Assistance with a Face Mask

1990 ◽  
Vol 323 (22) ◽  
pp. 1523-1530 ◽  
Author(s):  
Laurent Brochard ◽  
Daniel Isabey ◽  
Jacques Piquet ◽  
Piedade Amaro ◽  
Jorge Mancebo ◽  
...  
Keyword(s):  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Chronic Obstructive Lung Disease ◽  
Face Mask ◽  
Chronic Obstructive ◽  
Acute Exacerbations

A Double-Blind Parallel Study of Acetylcysteine-Isoproterenol and Saline-Isoproterenol in Patients with Chronic Obstructive Lung Disease

1977 ◽  
Vol 5 (3) ◽  
pp. 175-183 ◽  
Author(s):  
Allen Cato ◽  
Ira Goldstein ◽  
Milton Millman
Keyword(s):  
Side Effects ◽  
Pulmonary Function ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Parallel Study ◽  
Double Blind ◽  
Safety And Efficacy ◽  
Pre Treatment

A double-blind parallel study in patients with asthma compared the safety and efficacy of saline-isoproterenol (SI) and acetylcysteine-isoproterenol (AI), when administered at home as an aerosol, over a one-week period, using a conventional nebulizer compressor. Measurements of pulmonary function revealed statistically significant differences between the two therapies for FEV1 and FVC in favour of AI. In the group treated with AI, the average sputum viscosity after six days of treatment was significantly less than pre-treatment values, or when compared to the results with SI treatment. No serious side-effects were reported during treatment with either therapy. These results indicate that acetylcysteine combined with a bronchodilator, such as isoproterenol, may be safe and of significant value in the treatment of patients with asthma who are also sputum producers.

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