Pyrophosphate formation from phospho(enol)pyruvate adsorbed onto precipitated orthophosphate: A model for prebiotic catalysis of transphosphorylations

1989 ◽  
Vol 19 (2) ◽  
pp. 143-152 ◽  
Author(s):  
Marcelo Hermes-Lima ◽  
Adalberto Vieyra
Keyword(s):  
Prebiotic Catalysis

Polyamino acids as synthetic enzymes: mechanism, applications and relevance to prebiotic catalysis

2005 ◽  
Vol 23 (10) ◽  
pp. 507-513 ◽  
Author(s):  
Giacomo Carrea ◽  
Stefano Colonna ◽  
David R. Kelly ◽  
Antonio Lazcano ◽  
Gianluca Ottolina ◽  
...  
Keyword(s):  
Synthetic Enzymes ◽  
Prebiotic Catalysis

scholarly journals Porphyrin in prebiotic catalysis: Ascertaining a route for the emergence of early metalloporphyrins

2021 ◽  
Author(s):  
Shikha Dagar ◽  
Susovan Sarkar ◽  
Sudha Rajamani
Keyword(s):  
Catalytic Activity ◽  
Molecular Evolution ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Ion ◽  
Selective Advantage ◽  
Metal Porphyrin ◽  
Catalytic Core ◽  
Prebiotic Catalysis ◽  
Mediated Oxidation

Metal ions are known to catalyze certain prebiotic reactions. However, the transition from metal ions to extant metalloenzymes remains unclear. Porphyrins are found ubiquitously in the catalytic core of many ancient metalloenzymes. In this study, we evaluated the influence of porphyrin-based organic scaffold, on the catalysis, emergence and putative molecular evolution of prebiotic metalloporphyrins. We studied the effect of porphyrins on the transition metal ion-mediated oxidation of hydroquinone (HQ). We report a change in the catalytic activity of the metal ions in the presence of porphyrin. This was observed to be facilitated by the coordination between metal ions and porphyrins or by formation of non-coordinated complexes. The metal-porphyrin complexes also oxidized NADH, underscoring its versatility at oxidizing more than one substrate. Our study highlights the selective advantage that some of the metal ions would have had in the presence of porphyrin, underscoring their role in shaping the evolution of protometalloenzymes.

Modeling prebiotic catalysis with nucleic acid-like polymers and its implications for the proposed RNA world

2004 ◽  
Vol 76 (12) ◽  
pp. 2085-2099 ◽  
Author(s):  
S. G. Srivatsan
Keyword(s):  
Nucleic Acid ◽  
De Novo ◽  
Rna World ◽  
Acid Synthesis ◽  
Polymerization Process ◽  
Rna Molecules ◽  
Catalytic Material ◽  
Evolution Of Life ◽  
Prebiotic Catalysis

The theory that RNA molecules played a pivotal role in the early evolution of life is now widely accepted. Studies related to this hypothetical “RNA world” include three major areas: the formation of precursors for the first RNA molecules, the polymerization process, and the potential of RNA to catalyze chemical and biochemical reactions. Several chemical and biochemical studies performed under simulated prebiotic conditions support the role of RNA as both genetic as well as catalytic material. However, owing to the lack of credible mechanism for de novo nucleic acid synthesis and the hydrolytic instability of RNA molecules, there has been some serious discussion of whether biopolymers that closely resembled nucleic acid preceded the “RNA world”. In this context, an overview of prebiotic chemistry, the role of mineral surface, and the significance of studies related to RNA-like polymers in the origin of life are presented here.

Chiral amplification by polypeptides and its relevance to prebiotic catalysis

2004 ◽  
pp. 2021 ◽  
Author(s):  
David R. Kelly ◽  
Alastair Meek ◽  
Stanley M. Roberts
Keyword(s):  
Chiral Amplification ◽  
Prebiotic Catalysis

The Structure And Synthetic Capabilities Of A Catalytic Peptide Formed By Substrate-Directed Mechanism – Implications To Prebiotic Catalysis

2005 ◽  
Vol 35 (4) ◽  
pp. 369-382 ◽  
Author(s):  
Gideon Fleminger ◽  
Tal Yaron ◽  
Miriam Eisenstein ◽  
Akiva Bar-Nun
Keyword(s):  
Prebiotic Catalysis
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