Chemical sympathectomy reveals pre-and postsynaptic effects of neuropeptide Y (NPY) in the cardiovascular system

1987 ◽  
Vol 43 (9) ◽  
pp. 1018-1020 ◽  
Author(s):  
Y. Mabe ◽  
R. Pérez ◽  
K. Tatemoto ◽  
J. P. Huidobro-Toro
Keyword(s):  
Neuropeptide Y ◽  
Cardiovascular System ◽  
Chemical Sympathectomy

Distribution and activity of dogfish NPY and peptide YY in the cardiovascular system of the common dogfish

1993 ◽  
Vol 264 (6) ◽  
pp. R1119-R1124 ◽  
Author(s):  
C. Bjenning ◽  
N. Hazon ◽  
A. Balasubramaniam ◽  
S. Holmgren ◽  
J. M. Conlon
Keyword(s):  
Neuropeptide Y ◽  
Cardiovascular System ◽  
Peptide Yy ◽  
Nerve Fibers ◽  
Dependent Manner ◽  
Cardiovascular Tissue ◽  
Y1 Receptor ◽  
Selective Agonist ◽  
Y2 Receptor ◽  
The Common

Neuropeptide Y is present in sympathetic nerves in the mammalian cardiovascular system. This study has investigated the distribution of neuropeptide Y in the cardiovascular and gastrointestinal systems and the effect of dogfish neuropeptide Y and related peptides on cardiovascular tissue of an elasmobranch fish, the common dogfish (Scyliorhinus canicula). Neuropeptide Y-like immunoreactivity is present in varicose nerve fibers innervating dogfish gut and cardiovascular tissue and in endocrine cells of the dogfish spiral intestine. Dogfish neuropeptide Y, dogfish peptide YY, and porcine neuropeptide Y contract the dogfish afferent branchial artery in a concentration-dependent manner. The effect is not inhibited by the presence of tetrodotoxin or by removal of the endothelium. The mammalian Y1 receptor selective agonist [Leu31Pro34]NPY but not the mammalian Y2 receptor selective agonist neuropeptide Y-(13-36) peptide has vasoconstrictor properties in this system, suggesting that the receptor mediating the vasoconstriction resembles the mammalian Y1 receptor more than the Y2 receptor.

Hemodynamic effects of posterior hypothalamic injection of neuropeptide Y in awake rats

1991 ◽  
Vol 261 (3) ◽  
pp. H814-H824 ◽  
Author(s):  
J. R. Martin ◽  
M. M. Knuepfer ◽  
T. C. Westfall
Keyword(s):  
Heart Rate ◽  
Cardiac Output ◽  
Neuropeptide Y ◽  
Cardiovascular System ◽  
Peripheral Resistance ◽  
Hypothalamic Nucleus ◽  
Initial Increase ◽  
System Control ◽  
Posterior Hypothalamic Nucleus ◽  
Freely Moving

Unilateral microinjection of neuropeptide Y (NPY) into the posterior hypothalamic nucleus was previously found to evoke a sympathoexcitatory-mediated increase in mean arterial pressure (MAP) in urethan-anesthetized rats. In this study, the effect of unilateral injection of NPY into the posterior hypothalamic nucleus on the cardiovascular system of conscious, freely moving rats was determined. Microinjection of NPY (0.2-2.4 nmol) or the cholinergic agonist carbachol (0.5-5.5 nmol) resulted in concentration-dependent increases in MAP. Pretreatment of animals with 7.5 mg/kg iv of the ganglionic blocker pentolinium resulted in a blockade of the increase in MAP evoked by microinjection of NPY (2.4 nmol) or carbachol (3.3 nmol). Despite their similarity of effects on MAP, NPY and carbachol evoked different changes in heart rate. NPY increased heart rate, whereas carbachol evoked a biphasic change in heart rate that consisted of an initial increase followed by a decrease. In addition, carbachol caused increases in both hindquarter and mesenteric vascular resistances, whereas NPY caused a short-lasting increase in mesenteric resistance and a tendency toward an increase in hindquarter resistance. Both NPY and carbachol increased total peripheral resistance while NPY decreased stroke volume. Cardiac output was not significantly affected by either NPY or carbachol, although NPY had a tendency to decrease cardiac output. These results suggest that microinjection of NPY or carbachol into the posterior hypothalamic nucleus of conscious rats evokes an increase in MAP primarily as a result of sympathoexcitation and that NPY and carbachol selectively affect autonomic nervous system control of the cardiovascular system.

Localisation of neuropeptide Y in nerves of the rat cardiovascular system and the effect of 6-hydroxydopamine

1985 ◽  
Vol 19 (9) ◽  
pp. 570-577 ◽  
Author(s):  
J. M ALLEN ◽  
J. M POLAK ◽  
J. RODRIGO ◽  
K. DARCY ◽  
S. R BLOOM
Keyword(s):  
Neuropeptide Y ◽  
Cardiovascular System ◽  
6 Hydroxydopamine

Long-term chemical sympathectomy leads to an increase of neuropeptide Y immunoreactivity in cerebrovascular nerves and iris of the developing rat

Neuroscience ◽  
1990 ◽  
Vol 34 (2) ◽  
pp. 369-378 ◽  
Author(s):  
M.C. Mione ◽  
J.F.R. Cavanagh ◽  
J. Lincoln ◽  
P. Milner ◽  
G. Burnstock
Keyword(s):  
Neuropeptide Y ◽  
Chemical Sympathectomy ◽  
Developing Rat

Effects of neuropeptide Y on the cardiovascular system

1987 ◽  
Vol 8 (6) ◽  
pp. 231-235 ◽  
Author(s):  
L. Edvinsson ◽  
R. Håkanson ◽  
C. Wahlestedt ◽  
R. Uddman
Keyword(s):  
Neuropeptide Y ◽  
Cardiovascular System

scholarly journals Depressed cardiac contractility and its postnatal development in rats after chemical sympathectomy

2008 ◽  
pp. 507-515
Author(s):  
J Švíglerová ◽  
J Kuncová ◽  
L Nalos ◽  
J Slavíková ◽  
M Štengl
Keyword(s):  
Left Ventricle ◽  
Right Ventricle ◽  
Neuropeptide Y ◽  
Postnatal Development ◽  
Cardiac Contractility ◽  
Papillary Muscles ◽  
Chemical Sympathectomy ◽  
Postnatal Maturation ◽  
Time Points ◽  
The Right

The contribution of the sympathetic innervation to the postnatal development of cardiac contractility remains unclear. In this study, the postnatal maturation of cardiac contractility was compared in control rats and rats after chemical sympathectomy. The chemical sympathectomy was induced by administration of 6-hydroxydopamine to newborn rats. At days 20, 40 and 60 of postnatal life, the contractile parameters and concentrations of sympathetic neurotransmitters were measured in both right and left ventricles. In rats with chemical sympathectomy, concentrations of norepinephrine were reduced almost completely in both ventricles at all time points. The contractility of the left ventricle papillary muscles was substantially decreased at all time points. In contrast, the contractility of the right ventricle papillary muscles was decreased only transiently, showing a recovery at day 60 regardless of the permanently decreased concentration of norepinephrine. The concentration of neuropeptide Y, another neurotransmitter present in sympathetic nerves, showed the same developmental trend as contractility: permanent reduction in the left ventricle, transient reduction with a recovery at day 60 in the right ventricle. The data indicate that the sympathetic nervous system plays an important role in the postnatal development of cardiac contractility and neuropeptide Y may contribute to this effect.

Neuropeptide Y is present in the sympathetic nerves of the cardiovascular system

1985 ◽  
Vol 14 (1) ◽  
pp. 108
Author(s):  
J.M. Allen ◽  
J. Rodrigo ◽  
J.M. Polak ◽  
S.R. Bloom
Keyword(s):  
Neuropeptide Y ◽  
Cardiovascular System ◽  
Sympathetic Nerves

Chemical sympathectomy does not change the density of neuropeptide Y (NPY)-containing nerves in the cerebral vessels of the rat

1988 ◽  
Vol 22 (4) ◽  
pp. 423 ◽  
Author(s):  
M.C. Mione ◽  
L. Corr ◽  
J. Aberdeen ◽  
P. Milner ◽  
J. Lincoln ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Cerebral Vessels ◽  
Chemical Sympathectomy

Origin and Actions of Neuropeptide Y in the Cardiovascular System

2003 ◽  
pp. 315-388 ◽  
Author(s):  
Zofia Zukowska-Grojec ◽  
Claes Wahlestedt
Keyword(s):  
Neuropeptide Y ◽  
Cardiovascular System
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