Influence of the intracellular free calcium level and calmodulin antagonists on prostaglandin and leukotriene synthesis in murine macrophages

1991 ◽  
Vol 32 (1-2) ◽  
pp. 82-84 ◽  
Author(s):  
V. Kaever ◽  
K. Wessel ◽  
H. H. Radeke ◽  
K. Resch
Keyword(s):  
Calcium Level ◽  
Intracellular Free Calcium ◽  
Free Calcium ◽  
Calmodulin Antagonists ◽  
Murine Macrophages

Dysfunction of Ca2+/ CaM kinase IIA cascades in basolateral amygdala of posttraumatic stress disorder rats

2011 ◽  
Vol 26 (S2) ◽  
pp. 178-178
Author(s):  
Y. Shi ◽  
F. Han
Keyword(s):  
Normal Level ◽  
Calcium Level ◽  
Basolateral Amygdala ◽  
Intracellular Free Calcium ◽  
Free Calcium ◽  
Rt Pcr ◽  
Control Groups ◽  
Male Wistar Rats ◽  
Polymerase Chain ◽  
Set Up

ObjectiveTo explore changes of Ca2+-CaM-CaMKIIα in basolateral amygdala of PTSD rats may reveal part of the pathogensis.MethodsThe SPS-method was used to set up the rat PTSD models. A total of 90 male Wistar rats were randomly divided into1d, 4d, 7d, 14d groups of SPS and normal control groups. The intracellular free calcium level in basolateral amygdala was examined by fluorescence spectrophotometer. CaM and CaMKIIα expression in basolateral amygdala were examined by immunohistochemistry, western blotting and reverse transcription-polymerase chain reaction (RT-PCR).ResultsThe intracellular free calcium level reached the peak 1 day after SPS stimulation, then gradually decreased to normal level. The expression of CaM 1day after SPS is also the most and then decreased to normal level. In contrast, CaMKIIα expression showed a significant down-regulation 1day after SPS throughout and then gradually increased to normal level. This findings suggest dysfunction of Ca2+-CaM-CaMKIIα in basolateral amygdala of PTSD rats.ConclusionThus, the trauma-induced enhanced anxiety appear to be associated with, and possibly caused by, changes of Ca2+-CaM-CaMKIIα in basolateral amygdala.

The ratio of macrophage prostaglandin and leukotriene synthesis is determined by the intracellular free calcium level

1990 ◽  
Vol 39 (8) ◽  
pp. 1313-1319 ◽  
Author(s):  
Volkhard Kaever ◽  
Hans-Jürgen Pfannkuche ◽  
Klaus Wessel ◽  
Klaus Resch
Keyword(s):  
Calcium Level ◽  
Intracellular Free Calcium ◽  
Free Calcium

scholarly journals Intracellular free calcium level and its response to cAMP stimulation in developingDictyosteliumcells transformed with jellyfish apoaequorin cDNA

FEBS Letters ◽  
1994 ◽  
Vol 337 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Shweta Saran ◽  
Hajime Nakao ◽  
Masao Tasaka ◽  
Hidetoshi Iida ◽  
Frederick I. Tsuji ◽  
...  
Keyword(s):  
Calcium Level ◽  
Intracellular Free Calcium ◽  
Free Calcium ◽  
Camp Stimulation

scholarly journals Superoxide anion increases intracellular free calcium in human myometrial cells.

1990 ◽  
Vol 265 (36) ◽  
pp. 22533-22536
Author(s):  
N Masumoto ◽  
K Tasaka ◽  
A Miyake ◽  
O Tanizawa
Keyword(s):  
Superoxide Anion ◽  
Intracellular Free Calcium ◽  
Free Calcium ◽  
Myometrial Cells
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