On the mechanism of action of some 4-aminoanalogues of folic acid

1961 ◽  
Vol 17 (3) ◽  
pp. 113-115 ◽  
Author(s):  
Véra Slavíková ◽  
K. Slavík
Keyword(s):  
Folic Acid ◽  
Mechanism Of Action

Studies of the mechanism of action of asulam in plants. Part II: Effect of asulam on the biosynthesis of folic acid

1981 ◽  
Vol 12 (3) ◽  
pp. 330-338 ◽  
Author(s):  
Ponnan Veerasekarana ◽  
Ralph C. Kirkwood ◽  
Edgar W. Parnell
Keyword(s):  
Folic Acid ◽  
Mechanism Of Action

Novel Therapeutics for Depression:L-methylfolate as a Trimonoamine Modulator and Antidepressant-Augmenting Agent

CNS Spectrums ◽  
2007 ◽  
Vol 12 (10) ◽  
pp. 739-744 ◽  
Author(s):  
Stephen M. Stahl
Keyword(s):  
Folic Acid ◽  
High Risk ◽  
Major Depression ◽  
Mechanism Of Action ◽  
Folate Deficiency ◽  
Major Depressive ◽  
Antidepressant Effects ◽  
Major Depressive Episodes ◽  
Depressive Episodes ◽  
Putative Mechanism

Folate deficiency may increase the risk of depression and reduce the action of antidepressants. Individuals with an inherited polymorphism that reduces the efficiency of folate formation may be at high risk for folate deficiency and for major depression. Antidepressant effects have been reported when antidepressants are augmented with folic acid, folinic acid, or the centrally active L-methylfolate (known formally as (6(S)-5-methyltetrahydrofolate [MTHF]), particularly in depressed patients with folate deficiency whose major depressive episodes have failed to respond to antidepressants. The putative mechanism of action of MTHF as an augmenting agent to antidepressants is that it acts as a trimonoamine modulator (TMM), enhancing the synthesis of the three monoamines: dopamine (DA), norepinephrine (NE), and serotonin (5-HT), resulting in a boost to the efficacy of antidepressants.

Drug and Environmental Factors Associated with Adverse Pregnancy Outcomes Part III: Folic Acid: Pharmacology, Therapeutic Recommendations, and Economics

1998 ◽  
Vol 32 (10) ◽  
pp. 1087-1095 ◽  
Author(s):  
Dale P Lewis ◽  
Don C Van Dyke ◽  
Phyllis J Stumbo ◽  
Mary J Berg
Keyword(s):  
Folic Acid ◽  
Mechanism Of Action ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Neural Tube Defect ◽  
Methylenetetrahydrofolate Reductase ◽  
Folate Intake ◽  
Cardiovascular Morbidity And Mortality ◽  
Cereal Grain ◽  
Therapeutic Recommendations

OBJECTIVE: To review folic acid's mechanism of action, adverse effects, therapeutic recommendations, compliance, and cost. DATA SOURCES: A MEDLINE search was conducted through December 1997. Additional sources were obtained from Current Contents and citations from the references obtained. Search terms included folate, folic acid, neural tube defect, homocysteine, and methylenetetrahydrofolate reductase. STUDY SELECTION: Animal and human studies examining the effects of folate were reviewed. DATA EXTRACTION: Data collected included mechanism of action, safety issues, dosing recommendations, compliance with recommendations, and economics. DATA SYNTHESIS: Folic acid decreases neural tube defect risk through an effect on methionine–homocysteine metabolism. In addition, increased folate intake may reduce cardiovascular morbidity and mortality. Since toxicity is minimal, everyone can potentially benefit from increased folate consumption. To help achieve this, the Food and Drug Administration has mandated that cereal grain be fortified with 140 μg of folic acid per 100 g of grain, which will add approximately 0.1 mg of folate to the average diet. Studies recommend supplementing with 0.2 mg to promote optimal homocysteine concentrations and for preventing neural tube defects. CONCLUSIONS: Despite fortification, most women will still receive less folate than the 0.4 mg/d recommended by the Public Health Service. All population groups would benefit from increased folate intake. Current studies indicate 200 μg/d may be the minimum effective amount of fortification needed for normalizing homocysteine concentrations and preventing a significant number of neural tube defects; thus, a higher level of food fortification may be warranted.

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