T cells or active epstein-barr virus infection in the development of lymphoproliferative disease in human B cell-injected severe combined immunodeficient mice

1994 ◽  
Vol 1 (5) ◽  
pp. 405-410 ◽  
Author(s):  
Robert E. Coles ◽  
Terrence J. Boyle ◽  
J. Michael DiMaio ◽  
Keith R. Berend ◽  
Dan F. Via ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Lymphoproliferative Disease ◽  
Epstein Barr Virus Infection ◽  
Immunodeficient Mice ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Human B Cell

Remarkable Depression of CD4+2H4+ T Cells in Severe Chronic Active Epstein-Barr Virus Infection

1987 ◽  
Vol 26 (6) ◽  
pp. 769-773 ◽  
Author(s):  
E. FRANCO ◽  
K. KAWA-HA ◽  
S. DOl ◽  
K. YUMURA ◽  
M. MURATA ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

Differential cellular susceptibility to Epstein-Barr virus infection in a patient with X-linked lymphoproliferative disease

1990 ◽  
Vol 32 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Motohiko Okano ◽  
Geoffrey M. Thiele ◽  
Thomas G. Gross ◽  
Jack R. Davis ◽  
David T. Purtilo
Keyword(s):  
Virus Infection ◽  
Epstein Barr Virus ◽  
Lymphoproliferative Disease ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

scholarly journals A Case Report of Lymphoproliferative Disease in Larynx with Chronic Active Epstein-Barr Virus Infection

2004 ◽  
Vol 16 (1) ◽  
pp. 56-59
Author(s):  
Hisaya Yukawa ◽  
Nobuo Kubo ◽  
Kaori Nakae ◽  
Hiroyuki Tsuji ◽  
Sachiko Fujimoto ◽  
...  
Keyword(s):  
Case Report ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Lymphoproliferative Disease ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

scholarly journals A new therapy in Epstein-Barr virus-associated lymphoproliferative disease: a case report and a revision of the literature

2019 ◽  
Vol 45 (1) ◽  
Author(s):  
Lingling Xu ◽  
Hongjun Ba ◽  
Hongrong Lin ◽  
Liangying Zhong ◽  
Suping Li ◽  
...  
Keyword(s):  
Virus Infection ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Internal Carotid ◽  
Lymphoproliferative Disease ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
The Right

Abstract Background Systemic chronic active Epstein-Barr virus infection is an extremely rare childhood disease. Since chronic active Epstein-Barr virus infection can trigger the onset of Epstein-Barr virus-associated lymphoproliferative disease. The clinical manifestations of the disease vary according to the site of involvement; therefore, management may be challenging. Currently, there are no standardized guidelines for treating Chronic active Epstein-Barr virus infection effectively. Case presentation We report a case of chronic active Epstein-Barr virus infection in a 5-year-old Chinese boy with intestinal, vascular, and neurological involvement. At age of 2 years and 7 months old, he had hepatomegaly and been diagnosed with Epstein-Barr virus infection. After treatment, he showed some clinical improvement. At age of 3 years and 3 months old, he presented with recurrent fever and diarrhea. Then he received methylprednisolone for 1 year and his symptoms ameliorated. At the age of 5 years, his symptoms recurred and had gastrointestinal hemorrhage and developed polyuria, frequent convulsions and hyponatremia. He was transferred to our hospital for further management. He was unconscious on admission and was diagnosised Epstein-Barr virus-lymphoproliferative disorder, based on the results in situ hybridization of EBV-encoded miRNA in sigmoid colon. Three-dimensional CT angiography demonstrated an aneurysm in the right internal carotid artery. Abdominal CT showed dilatation of vessels in part of the intestinal wall. He was also diagnosised Epstein-Barr virus encephalitis based on the elevated Epstein-Barr virus antibody titers and presence of Epstein-Barr virus DNA in the Cerebrospinal Fluid. A repeated duodenal artery embolization and symptomatic therapy could not control the hemorrhage after admission. He subsequently received treatment with ganciclovir, glucocorticoid, thalidomide, and propranolol. Hemorrhage was controlled in 5 days; his symptoms improved. The fever did not recur and the CSF pressure was also normalized. A follow-up CT at 3 months after admission showed regression of the aneurysm in the right internal carotid artery and the vascular lesion in the duodenum. Discussion and conclusions A new treatment protocol including thalidomide and propranolol resulted in a marked improvement in his clinical symptoms, and shows promise as a novel and effective therapeutic approach for Chronic active Epstein-Barr virus infection-associated lymphoproliferative disorder.

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