Expression of epidermal growth factor receptor (proto-oncogene c-erbB-1) and estrogen receptor in human breast carcinoma

1993 ◽  
Vol 252 (4) ◽  
pp. 169-177 ◽  
Author(s):  
C. Garcìa Castro ◽  
M. Ravina ◽  
V. Castro ◽  
E. C. Salido
Keyword(s):  
Estrogen Receptor ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Breast Carcinoma ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Human Breast Carcinoma ◽  
Human Breast ◽  
Epidermal Growth

Immunohistochemical and Clinicopathologic Characteristics of Invasive Ductal Carcinoma of Breast With Micropapillary Carcinoma Component

2005 ◽  
Vol 129 (10) ◽  
pp. 1277-1282 ◽  
Author(s):  
Mi-Jung Kim ◽  
Gyungyub Gong ◽  
Hee Jae Joo ◽  
Se-Hyun Ahn ◽  
Jae Y. Ro
Keyword(s):  
Estrogen Receptor ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Breast Carcinoma ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Invasive Breast Carcinoma ◽  
Nodal Metastases ◽  
Micropapillary Carcinoma ◽  
Epidermal Growth

Abstract Context.—A micropapillary carcinoma (MC) component is generally considered to behave aggressively. Although several reports have described the prognostic significance of MC in breast carcinomas, immunohistochemical findings of MC, especially as compared to non-MC, are rarely described. Objective.—We compared clinicopathologic and immunohistochemical findings between 38 cases of invasive breast carcinoma with an MC component (IMC) and 217 cases of invasive breast carcinoma without an MC component (NIMC). Design.—We constructed a tissue microarray from 38 cases of IMC and performed immunohistochemical stainings for cytokeratin (CK) 7, CK20, estrogen receptor, progesterone receptor, p53, c-Erb-B2, CD34, CK5, epidermal growth factor receptor, and c-Kit in both MC and non-MC components. Results.—Cases with IMC were associated with greater tumor size, more frequent lymphovascular invasion, nodal metastases, greater mean numbers of positive lymph nodes, and higher stage than those with NIMC, but were not associated with poorer survival rates. On immunohistochemistry, only p53 reactivity was statistically different between MC and non-MC components in IMC cases. Estrogen receptor positivity tended to be lower in MC than non-MC, but the difference was not significant. Most of the MCs and non-MCs in IMC cases were positive for CK7, but none of them were positive for CK20, CK5, epidermal growth factor receptor, or c-Kit. Conclusions.—Based on the frequent nodal metastases and association with higher stage found in IMC as compared with NIMC cases, as well as higher p53 positivity and lower frequency of estrogen receptor expression, MC could be considered an aggressive histologic type of breast carcinoma. In both MC and non-MC components in IMC cases, no basallike immunostaining pattern was detected.

scholarly journals Immunohistochemical Staining of Estrogen Receptor and Human Epidermal Growth Factor Receptor 2 in Carcinoma Breast in Bangladeshi Women

2016 ◽  
Vol 11 (1) ◽  
pp. 7-13
Author(s):  
Md Jaynul Islam ◽  
Selina Akhter ◽  
SM Mahbubul Alam ◽  
Md Yousuf Ali ◽  
Shamoli Yesmin
Keyword(s):  
Estrogen Receptor ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Breast Carcinoma ◽  
Epidermal Growth Factor ◽  
Ductal Carcinoma ◽  
Growth Factor Receptor ◽  
Human Epidermal Growth Factor ◽  
Her 2 ◽  
Epidermal Growth

Introduction: Breast cancer is the most common cause of cancer death among women. Estrogen Receptor (ER), Progesterone Receptor (PR) and human epidermal growth factor receptor 2 (Her-2/ neu) status are used as an important prognostic marker for breast cancer.Objectives: The aim of this study was to evaluate ER and Her-2 in breast carcinoma among Bangladeshi women and to co-relate with other prognostic parameters.Materials and Methods: The study was carried out in a tertiary level hospital in Bangladesh during the period of January 2010 to December 2011. Total 100 histologically proved breast carcinoma cases were included in the study. Immunostaining for ER and Her-2/neu were carried out. Quick scoring of ER and expression of Her-2/neu were correlated with histomorphological parameters.Results: Among 100 cases 93 were ductal carcinoma and 07 were non ductal. Among all, 38% show ER positive (score- 3-8) while 62% are ER negative (score 0-2). Her-2/neu was over expressed in 30%, 22% were borderline and 48% were negative. There were inverse relationship between ER positivity and Her-2/neu overexpression. ER positivity was related with lower histological grade, while Her-2/neu overexpression was related with higher histological grade.Conclusions: ER positivity in Breast carcinoma patients in Bangladesh is lower in comparison to western literature while Her-2/neu overexpression rate is quite high like other Asian countries.Journal of Armed Forces Medical College Bangladesh Vol.11(1) 2015: 7-13

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