Transplantation of cultured fetal pancreatic islet cells in the treatment of insulin-dependent diabetes mellitus

1994 ◽  
Vol 117 (4) ◽  
pp. 357-364 ◽  
Author(s):  
N. N. Skaletskii ◽  
N. L. Fateeva ◽  
G. T. Sukhikh ◽  
E. M. Molnar
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Islet ◽  
Islet Cells ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Pancreatic Islet Cells ◽  
Insulin Dependent

scholarly journals Effect of an oral α2-adrenergic blocker (MK-912) on pancreatic islet function in non-insulin-dependent diabetes mellitus

Metabolism ◽  
1991 ◽  
Vol 40 (11) ◽  
pp. 1160-1167 ◽  
Author(s):  
F.Javier Ortiz-Alonso ◽  
William H. Herman ◽  
Barry J. Gertz ◽  
Vanessa C. Williams ◽  
Marla J. Smith ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Islet ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Islet Function ◽  
Adrenergic Blocker ◽  
Insulin Dependent

Pancreatic and Islet Replacement Therapy For Insulin-Dependent Diabetes Mellitus

1993 ◽  
Vol 32 (5) ◽  
pp. 258-263 ◽  
Author(s):  
Ben H. Brouhard ◽  
Douglas G. Rogers
Keyword(s):  
Diabetes Mellitus ◽  
Islet Cells ◽  
Insulin Dependent Diabetes Mellitus ◽  
Normal Function ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Islet Cell Transplantation ◽  
Term Survival ◽  
Insulin Dependent

The only known cure for insulin-dependent diabetes mellitus is transplantation of functioning islet cells, either alone or via transplantation of the entire pancreas in sufficient mass to restore normal carbohydrate metabolism. Such therapy may also ameliorate or eliminate certain long-term consequences of diabetes. More than 3,000 patients have received pancreas transplants at 150 centers worldwide since 1966. Urinary drainage of pancreatic exocrine secretions has dramatically improved long-term survival, especially when a kidney was transplanted at the same time. Metabolic control then resumes normal function for up to six years, in some cases preventing or reversing long-term complications of diabetes. While nephropathy and neuropathy can be prevented and even somewhat reversed, retinopathy and neuropathy resist improvement. The large number of islets that must be harvested makes islet cell transplantation difficult to achieve, although the process has been accomplished in humans with limited success.

scholarly journals Human pancreatic islet function at the onset of Type 1 (insulin-dependent) diabetes mellitus

Diabetologia ◽  
1993 ◽  
Vol 36 (4) ◽  
pp. 358-360 ◽  
Author(s):  
I. Conget ◽  
J. Fern�ndez-Alvarez ◽  
J. Ferrer ◽  
Y. Sarri ◽  
A. Novials ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Islet ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Islet Function ◽  
Human Pancreatic Islet ◽  
Insulin Dependent
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