Characterization of a continuous human glioma cell line DBTRG-05MG: growth kinetics, karyotype, receptor expression, and tumor suppressor gene analyses

1992 ◽  
Vol 28 (9-10) ◽  
pp. 609-614 ◽  
Author(s):  
Carol A. Kruse ◽  
Dawn H. Mitchell ◽  
Bette K. Kleinschmidt-DeMasters ◽  
Wilbur A. Franklin ◽  
Helvise G. Morse ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Cell Line ◽  
Tumor Suppressor Gene ◽  
Growth Kinetics ◽  
Glioma Cell ◽  
Suppressor Gene ◽  
Glioma Cell Line ◽  
Receptor Expression ◽  
Human Glioma

scholarly journals Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line

FEBS Letters ◽  
1986 ◽  
Vol 201 (1) ◽  
pp. 109-113 ◽  
Author(s):  
J.-E. Månsson ◽  
P. Fredman ◽  
D.D. Bigner ◽  
K. Molin ◽  
B. Rosengren ◽  
...  
Keyword(s):  
Cell Line ◽  
Glioma Cell ◽  
Glioma Cell Line ◽  
Human Glioma ◽  
Human Glioma Cell Line ◽  
Human Glioma Cell

Characterization of hyaluronan synthase from a human glioma cell line

1998 ◽  
Vol 1380 (3) ◽  
pp. 377-388 ◽  
Author(s):  
Tomas Asplund ◽  
Jonas Brinck ◽  
Masanobu Suzuki ◽  
Michael J Briskin ◽  
Paraskevi Heldin
Keyword(s):  
Cell Line ◽  
Glioma Cell ◽  
Glioma Cell Line ◽  
Hyaluronan Synthase ◽  
Human Glioma ◽  
Human Glioma Cell Line ◽  
Human Glioma Cell

scholarly journals P01.17 * ROLE OF PHOSPHATYDILCHOLINE-SPECIFIC PHOSPHOLIPASE C IN MODULATION OF CXCL12/CXCR4 AXIS IN A HUMAN GLIOMA CELL LINE

2014 ◽  
Vol 16 (suppl 2) ◽  
pp. ii30-ii30 ◽  
Author(s):  
L. Mercurio ◽  
A. Ricci ◽  
S. Cecchetti ◽  
A. Pacella ◽  
F. Podo ◽  
...  
Keyword(s):  
Phospholipase C ◽  
Cell Line ◽  
Glioma Cell ◽  
Glioma Cell Line ◽  
Human Glioma ◽  
Human Glioma Cell Line ◽  
Human Glioma Cell ◽  
Cxcr4 Axis

Characterization of HRG22, a Human Homologue of the Putative Tumor Suppressor Gene HIC1

2001 ◽  
Vol 287 (2) ◽  
pp. 427-434 ◽  
Author(s):  
Sophie Deltour ◽  
Sébastien Pinte ◽  
Cateline Guérardel ◽  
Dominique Leprince
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Human Homologue ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor

scholarly journals Characterization of cells recovered from the xenotransplanted NG97 human-derived glioma cell line subcultured in a long-term in vitro

BMC Cancer ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Camila ML Machado ◽  
Rafael Y Ikemori ◽  
Tatiana Q Zorzeto ◽  
Ana CMA Nogueira ◽  
Suse DS Barbosa ◽  
...  
Keyword(s):  
Cell Line ◽  
Glioma Cell ◽  
Glioma Cell Line

scholarly journals Functional evidence for a second tumor suppressor gene on human chromosome 17

1994 ◽  
Vol 14 (1) ◽  
pp. 534-542
Author(s):  
P Chen ◽  
N Ellmore ◽  
B E Weissman
Keyword(s):  
Tumor Suppressor ◽  
Cell Line ◽  
Tumor Suppressor Gene ◽  
Cell Lines ◽  
Suppressor Gene ◽  
Chromosome 17 ◽  
Hybrid Cells ◽  
Tumorigenic Potential ◽  
Normal Human ◽  
Second Tumor

The development and progression of human tumors often involves inactivation of tumor suppressor gene function. Observations that specific chromosome deletions correlate with distinct groups of cancer suggest that some types of tumors may share common defective tumor suppressor genes. In support of this notion, our initial studies showed that four human carcinoma cell lines belong to the same complementation group for tumorigenic potential. In this investigation, we have extended these studies to six human soft tissue sarcoma cell lines. Our data showed that hybrid cells between a peripheral neuroepithelioma (PNET) cell line and normal human fibroblasts or HeLa cells were nontumorigenic. However, hybrid cells between the PNET cell line and five other soft tissue sarcoma cell lines remained highly tumorigenic, suggesting at least one common genetic defect in the control of tumorigenic potential in these cells. To determine the location of this common tumor suppressor gene, we examined biochemical and molecular polymorphic markers in matched pairs of tumorigenic and nontumorigenic hybrid cells between the PNET cell line and a normal human fibroblast. The data showed that loss of the fibroblast-derived chromosome 17 correlated with the conversion from nontumorigenic to tumorigenic cells. Transfer of two different chromosome 17s containing a mutant form of the p53 gene into the PNET cell line caused suppression of tumorigenic potential, implying the presence of a second tumor suppressor gene on chromosome 17.

Sign in / Sign up

Export Citation Format

Share Document