In vivo and in vitro31P MRS studies on myocardial energy metabolism of brain dead cats

2000 ◽  
Vol 11 (1) ◽  
pp. 23-26
Author(s):  
G. J. Brandon Bravo Bruinsma ◽  
J. J. Bredée ◽  
T. J. C. Ruigrok ◽  
C. J. A. Echteld
Keyword(s):  
Energy Metabolism ◽  
Myocardial Energy Metabolism ◽  
Brain Dead

Validity of the microdialysis technique for experimental in vivo studies of myocardial energy metabolism

2003 ◽  
Vol 179 (1) ◽  
pp. 61-65 ◽  
Author(s):  
M. Kavianipour ◽  
G. Wikström ◽  
G. Ronquist ◽  
A. Waldenström
Keyword(s):  
Energy Metabolism ◽  
In Vivo Studies ◽  
Myocardial Energy Metabolism

scholarly journals Clinical motivation for31P MRS studies on the myocardial energy metabolism of brain dead cats

2003 ◽  
Vol 17 (2-3) ◽  
pp. 503-510
Author(s):  
G. J. Brandon Bravo Bruinsma ◽  
C. J. A. Van Echteld
Keyword(s):  
Energy Metabolism ◽  
Brain Death ◽  
Hemodynamic Instability ◽  
High Energy ◽  
Exclusion Criterion ◽  
High Energy Phosphates ◽  
Myocardial Energy Metabolism ◽  
Brain Dead ◽  
The Brain ◽  
Death Group

Hemodynamic instability of the brain dead potential heart donor is an exclusion criterion for heart donation for transplantation. Based on the results of myocardial biopsies it has been reported that brain death-related catecholamine induced damage of the heart causes depletion of high-energy phosphates which could explain contractile dysfunction. Our group has shown in a series of31P MRS experiments in cats that neither the onset of brain death, nor the hemodynamic deterioration which follows, nor its treatment with high dosages of dopamine affect the heart energetically as expressed by PCr/ATP ratios. However, after cardioplegic arrest and explantation, an initial and prolonged lower ATP content and an anomalous higher PCr/ATP ratio in the brain death group was found when compared with controls during long-term unperfused cold storage of the hearts. During subsequent reperfusion of the hearts, ATP and PCr levels in the brain death group were lower than in controls but equal partial recovery of PCr/ATP ratios was observed in both groups. It was concluded that PCr/ATP ratios need to be interpreted with great caution. Secondly, brain death-related hemodynamic instability is not related to significant changes of myocardial energy metabolism. Thirdly, brain death does affect the myocardial energy metabolism but the impact became apparent only during hypothermic storage and subsequent reperfusion of the donor heart.

scholarly journals In vivo Profile of Myocardial Energy Metabolism of Pressure-overloaded Rat.

1993 ◽  
Vol 34 (3) ◽  
pp. 313-331 ◽  
Author(s):  
Satoshi TAKEO ◽  
Kouichi TANONAKA ◽  
Manabu AOKI ◽  
Yasufumi NAKAI ◽  
Atsushi SANBE ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Myocardial Energy Metabolism

Effects of in Vivo Heart Irradiation on Myocardial Energy Metabolism in Rats

1993 ◽  
Vol 134 (1) ◽  
pp. 79 ◽  
Author(s):  
N. A. P. Franken ◽  
L. Hollaar ◽  
F. J. Bosker ◽  
F. J. M. van Ravels ◽  
A. van der Laarse ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Myocardial Energy Metabolism
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