Cardiac Function in Brain Death, Usage of Advanced Hemodynamic Monitoring

Background: This study used advanced hemodynamic monitoring along with simultaneous echocardiography to assess donated heart function of brain death patients using advanced hemodynamic monitoring and its efficacy in organ donation. Methods: Forty-eight brain death patients who were candidates of heart donation on the basis of primary standard investigations were selected with purposive and convenient sampling methods. They were investigated with advanced hemodynamic monitoring after echocardiography and primary assessments and the gleaned data were recorded. Results: Echocardiography showed that LVS (left ventricle size) and LVF (left ventricle function) were normal in %100 and %87.5 of patients, respectively. LVEF (left ventricle ejection fraction) was <%50 in %12.5 and >%50 in %87.5 of patients. SVR was smaller than 1200 at the beginning of the study that reached %54.4 at the end of the study. CI (cardiac index) was < 2.4 in %16.7 of the patients at the onset of the study that reached %25 at the end. Reduction of CI and SVR in patients with EF <%50 was significantly higher than that in patients with EF>%50. Conclusion: Given the extensive pathological changes in the cardiovascular system exerted by brain death, advanced hemodynamic monitoring, if performed continually, can greatly aid in managing inotropic drugs in these patients, decision-making for managing intravascular volume, creating hemodynamic stability, and finally, preventing deterioration of function of the donated heart and loss of a donated organ.

BRAIN DEATH DIAGNOSIS IN SEVERE TRAUMATIC BRAIN INJURY (TBI)

Проведено клинико-неврологическое и инструментальное исследование смерти мозга у 23 пациентов с тяжелой черепно-мозговой травмой за 2020 год. Результаты исследования показали, что летальность в первые 72 часа была в 14 случаях - 60,9%. Досуточная летальность составила 9 случаев - 39,1 %. Пациенты трудоспособного возраста составили 83%. В большинстве случаев клиническая картина смерти мозга осложнялась наличием травм лица, спонтанными или индуцированными автоматизмами, ушибом легких при сочетанной травме. В данной статье описаны виды клинических исследований, используемых в диагностике смерти мозга, в сложных случаях дополнительных подтверждающих тестов. Research has been done of 23 patients with а severe traumatic brain injury (TBI) in 2020. Outcomes of our research have indicated mortality in the first 72 hours was in 14 cases - 60,9%.And the first day lethality was 9 cases - 39,1%. The significant quantity of working age patients amounts to 83%. Generally, brain death in any patient with catastrophic brain injury and a bedside exam consistent with brain death complicated by facial injuries, spontaneous or induced automatism, lungs contusion with concomitant injury. The article describes types of clinical examination, used in the definition of brain death. In complicated cases, supplementary confirm tests.