Estimation of blood flow heterogeneity distribution in human skeletal muscle from positron emission tomography data

1997 ◽  
Vol 25 (5) ◽  
pp. 906-910 ◽  
Author(s):  
Paolo Vicini ◽  
Riccardo C. Bonadonna ◽  
Tapio Utriainen ◽  
Pirjo Nuutila ◽  
Maria Raitakari ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Positron Emission Tomography ◽  
Blood Flow ◽  
Human Skeletal Muscle ◽  
Emission Tomography ◽  
Flow Heterogeneity ◽  
Positron Emission ◽  
Heterogeneity Distribution ◽  
Blood Flow Heterogeneity ◽  
Tomography Data

scholarly journals Positron emission tomography detects greater blood flow and less blood flow heterogeneity in the exercising skeletal muscles of old compared with young men during fatiguing contractions

2013 ◽  
Vol 592 (2) ◽  
pp. 337-349 ◽  
Author(s):  
Thorsten Rudroff ◽  
Jessica A. Weissman ◽  
Marco Bucci ◽  
Marko Seppänen ◽  
Kimmo Kaskinoro ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Skeletal Muscles ◽  
Young Men ◽  
Emission Tomography ◽  
Flow Heterogeneity ◽  
Positron Emission ◽  
Blood Flow Heterogeneity ◽  
Fatiguing Contractions

Assessment of Skeletal Muscle Ventricle Tissue Blood Flow Using Positron Emission Tomography

2001 ◽  
Vol 25 (4) ◽  
pp. 306-312
Author(s):  
Tajinder P. Singh ◽  
Kevin Greer ◽  
Otto Muzik ◽  
Robert L. Hammond ◽  
Larry W. Stephenson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Positron Emission Tomography ◽  
Blood Flow ◽  
Emission Tomography ◽  
Tissue Blood Flow ◽  
Positron Emission

Muscle blood flow and flow heterogeneity during exercise studied with positron emission tomography in humans

2000 ◽  
Vol 83 (4-5) ◽  
pp. 395-401 ◽  
Author(s):  
Kari K. Kalliokoski ◽  
Jukka Kemppainen ◽  
Kirsti Larmola ◽  
Teemu O. Takala ◽  
Pauliina Peltoniemi ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Muscle Blood Flow ◽  
Emission Tomography ◽  
Flow Heterogeneity ◽  
Positron Emission

Functional electrical stimulation effect on skeletal muscle blood flow measured with H215O positron emission tomography

1998 ◽  
Vol 79 (6) ◽  
pp. 641-646 ◽  
Author(s):  
Oscar U. Scremin ◽  
Ramon L. Cuevas-Trisan ◽  
A.M.Erika Scremin ◽  
Charles V. Brown ◽  
Mark A. Mandelkern
Keyword(s):  
Skeletal Muscle ◽  
Positron Emission Tomography ◽  
Blood Flow ◽  
Electrical Stimulation ◽  
Functional Electrical Stimulation ◽  
Muscle Blood Flow ◽  
Emission Tomography ◽  
Skeletal Muscle Blood Flow ◽  
Positron Emission

scholarly journals Quantitative Assessment of Glucose Transport in Human Skeletal Muscle: Dynamic Positron Emission Tomography Imaging of [O-Methyl-11C]3-O-Methyl-d-Glucose

2005 ◽  
Vol 90 (3) ◽  
pp. 1752-1759 ◽  
Author(s):  
Alessandra Bertoldo ◽  
Julie Price ◽  
Chet Mathis ◽  
Scott Mason ◽  
Daniel Holt ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Positron Emission Tomography ◽  
Glucose Transport ◽  
Pet Imaging ◽  
Human Skeletal Muscle ◽  
Insulin Infusion ◽  
Emission Tomography ◽  
Dynamic Pet ◽  
Positron Emission ◽  
18F Fdg

Insulin-stimulated glucose transport in skeletal muscle is regarded as a key determinant of insulin sensitivity, yet isolation of this step for quantification in human studies is a methodological challenge. One notable approach is physiological modeling of dynamic positron emission tomography (PET) imaging using 2-[18-fluoro]2-deoxyglucose ([18F]FDG); however, this has a potential limitation in that deoxyglucose undergoes phosphorylation subsequent to transport, complicating separate estimations of these steps. In the current study we explored the use of dynamic PET imaging of [11C]3-O-methylglucose ([11C]3-OMG), a glucose analog that is limited to bidirectional glucose transport. Seventeen lean healthy volunteers with normal insulin sensitivity participated; eight had imaging during basal conditions, and nine had imaging during euglycemic insulin infusion at 30 mU/min·m2. Dynamic PET imaging of calf muscles was conducted for 90 min after the injection of [11C]3-OMG. Spectral analysis of tissue activity indicated that a model configuration of two reversible compartments gave the strongest statistical fit to the kinetic pattern. Accordingly, and consistent with the structure of a model previously used for [18F]FDG, a two-compartment model was applied. Consistent with prior [18F]FDG findings, insulin was found to have minimal effect on the rate constant for movement of [11C]3-OMG from plasma to tissue interstitium. However, during insulin infusion, a robust and highly significant increase was observed in the kinetics of inward glucose transport; this and the estimated tissue distribution volume for [11C]3-OMG increased 6-fold compared with basal conditions. We conclude that dynamic PET imaging of [11C]3-OMG offers a novel quantitative approach that is both chemically specific and tissue specific for in vivo assessment of glucose transport in human skeletal muscle.

Estimation of Blood Flow Heterogeneity in Human Skeletal Muscle Using Intravascular Tracer Data: Importance for Modeling Transcapillary Exchange

10.1114/1.64 ◽  
1998 ◽  
Vol 26 (5) ◽  
pp. 764-774 ◽  
Author(s):  
Paolo Vicini ◽  
Riccardo C. Bonadonna ◽  
Mikko Lehtovirta ◽  
Leif C. Groop ◽  
Claudio Cobelli
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Human Skeletal Muscle ◽  
Transcapillary Exchange ◽  
Flow Heterogeneity ◽  
Blood Flow Heterogeneity
Sign in / Sign up

Export Citation Format

Share Document