Estimation of Blood Flow Heterogeneity in Human Skeletal Muscle Using Intravascular Tracer Data: Importance for Modeling Transcapillary Exchange

10.1114/1.64 ◽  
1998 ◽  
Vol 26 (5) ◽  
pp. 764-774 ◽  
Author(s):  
Paolo Vicini ◽  
Riccardo C. Bonadonna ◽  
Mikko Lehtovirta ◽  
Leif C. Groop ◽  
Claudio Cobelli
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Human Skeletal Muscle ◽  
Transcapillary Exchange ◽  
Flow Heterogeneity ◽  
Blood Flow Heterogeneity

Estimation of blood flow heterogeneity distribution in human skeletal muscle from positron emission tomography data

1997 ◽  
Vol 25 (5) ◽  
pp. 906-910 ◽  
Author(s):  
Paolo Vicini ◽  
Riccardo C. Bonadonna ◽  
Tapio Utriainen ◽  
Pirjo Nuutila ◽  
Maria Raitakari ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Positron Emission Tomography ◽  
Blood Flow ◽  
Human Skeletal Muscle ◽  
Emission Tomography ◽  
Flow Heterogeneity ◽  
Positron Emission ◽  
Heterogeneity Distribution ◽  
Blood Flow Heterogeneity ◽  
Tomography Data

scholarly journals Computational Assessment of Blood Flow Heterogeneity in Peritoneal Dialysis Patients' Cardiac Ventricles

2018 ◽  
Vol 9 ◽  
Author(s):  
Sanjay R. Kharche ◽  
Aaron So ◽  
Fabio Salerno ◽  
Ting-Yim Lee ◽  
Chris Ellis ◽  
...  
Keyword(s):  
Blood Flow ◽  
Peritoneal Dialysis ◽  
Dialysis Patients ◽  
Flow Heterogeneity ◽  
Cardiac Ventricles ◽  
Blood Flow Heterogeneity

Blood flow distribution in working in situ canine muscle during blood flow reduction

1996 ◽  
Vol 80 (6) ◽  
pp. 1978-1983 ◽  
Author(s):  
S. S. Kurdak ◽  
B. Grassi ◽  
P. D. Wagner ◽  
M. C. Hogan
Keyword(s):  
Blood Flow ◽  
Muscle Blood Flow ◽  
Flow Distribution ◽  
Blood Flow Distribution ◽  
Strong Negative Correlation ◽  
Flow Heterogeneity ◽  
Blood Flow Reduction ◽  
Blood Flow Heterogeneity

The purpose of this study was to determine whether reduction in apparent muscle O2 diffusing capacity (Dmo2) calculated during reduced blood flow conditions in maximally working muscle is a reflection of alterations in blood flow distribution. Isolated dog gastrocnemius muscle (n = 6) was stimulated for 3 min to achieve peak O2 uptake (VO2) at two levels of blood flow (controlled by pump perfusion): control (C) conditions at normal perfusion pressure (blood flow = 111 +/- 10 ml.100 g-1.min-1) and reduced blood flow treatment [ischemia (I); 52 +/- 6 ml.100 g-1.min-1]. In addition, maximal vasodilation was achieved by adenosine (A) infusion (10(-2)M) at both levels of blood flow, so that each muscle was subjected randomly to a total of four conditions (C, CA, I, and IA; each separated by 45 min of rest). Muscle blood flow distribution was measured with 15-microns-diameter colored microspheres. A numerical integration technique was used to calculate Dmo2 for each treatment with use of a model that calculates O2 loss along a capillary on the basis of Fick's law of diffusion. Peak VO2 was reduced significantly (P < 0.01) with ischemia and was unchanged by adenosine infusion at either flow rate (10.6 +/- 0.9, 9.7 +/- 1.0, 6.7 +/- 0.2, and 5.9 +/- 0.8 ml.100 g-1.min-1 for C, CA, I, and IA, respectively). Dmo2 was significantly lower by 30-35% (P < 0.01) when flow was reduced (except for CA vs. I; 0.23 +/- 0.03, 0.20 +/- 0.02, 0.16 +/- 0.01, and 0.13 +/- 0.01 ml.100 g-1.min-1.Torr-1 for C, CA, I, and IA, respectively). As expressed by the coefficient of variation (0.45 +/- 0.04, 0.47 +/- 0.04, 0.55 +/- 0.03, and 0.53 +/- 0.04 for C, CA, I, and IA, respectively), blood flow heterogeneity per se was not significantly different among the four conditions when examined by analysis of variance. However, there was a strong negative correlation (r = 0.89, P < 0.05) between Dmo2 and blood flow heterogeneity among the four conditions, suggesting that blood flow redistribution (likely a result of a decrease in the number of perfused capillaries) becomes an increasingly important factor in the determination of Dmo2 as blood flow is diminished.

scholarly journals Microdialysis of skeletal muscle at rest

1999 ◽  
Vol 58 (4) ◽  
pp. 919-923 ◽  
Author(s):  
Jan Henriksson
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Human Skeletal Muscle ◽  
Human Metabolism ◽  
High Expectations ◽  
Perfusate Flow ◽  
Muscle Research ◽  
Interstitial Glucose

Techniques in human skeletal muscle research are by necessity predominantly 'descriptive'.Microdialysis has raised high expectations that it could meet the demand for a method that allows 'mechanistic' investigations to be performed in human skeletal muscle. In the present review, some views are given on how well the initial expectations on the use of the microdialysis technique in skeletal muscle have been fulfilled, and the areas in which additional work is needed in order to validate microdialysis as an important metabolic technique in this tissue. The microdialysis catheter has been equated to an artificial blood vessel, which is introduced into the tissue. By means of this 'vessel' the concentrations of compounds in the interstitial space can be monitored. The concentration of substances in the collected samples is dependent on the rate of perfusate flow. When perfusate flow is slow enough to allow complete equilibration between interstitial and perfusate fluids, the concentration in the perfusate is maximal and identical to the interstitial concentration. Microdialysis data may be influenced by changes in blood flow, especially in instances where the tissue diffusivity limits the recovery in vivo, i.e. when recovery in vitro is 100 %, whereas the recovery in vivo is less than 100 %. Microdialysis data indicate that a significant arterial-interstitial glucose concentration gradient exists in skeletal muscle but not in adipose tissue at rest. While the concentrations of glucose and lactate in the dialysate from skeletal muscle are close to the expected values, the glycerol values obtained for muscle are still puzzling. Ethanol added to the perfusate will be cleared by the tissue at a rate that is determined by the nutritive blood flow (the microdialysis ethanol technique). It is concluded that microdialysis of skeletal muscle has become an important technique for mechanistic studies in human metabolism and nutrition.

BLOOD FLOW AND TRANSCAPILLARY EXCHANGE IN SKELETAL MUSCLE

1968 ◽  
pp. 83-91
Author(s):  
EUGENE M. RENKIN
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Transcapillary Exchange

scholarly journals Physiological responses of human skeletal muscle to acute blood flow restricted exercise assessed by multimodal MRI

2020 ◽  
Vol 129 (4) ◽  
pp. 748-759
Author(s):  
Bryan Haddock ◽  
Sofie K. Hansen ◽  
Ulrich Lindberg ◽  
Jakob Lindberg Nielsen ◽  
Ulrik Frandsen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Human Skeletal Muscle ◽  
Knee Extensor ◽  
Blood Oxygenation ◽  
Cross Sectional ◽  
Physiological Variables ◽  
Acute Changes ◽  
Response To Exercise ◽  
Blood Flow Restricted Exercise

Acute changes in blood flow, diffusion, blood oxygenation, cross-sectional area, and the “T2 shift” are evaluated in human skeletal muscle in response to blood flow-restricted (BFR) and conventional free-flow knee extensor exercise performed in an MRI scanner. The acute physiological response to exercise was dependent on the magnitude of load and the application of BFR. Physiological variables changed markedly and established a steady state rapidly after the first of four exercise sets.

Pulmonary Blood Flow Heterogeneity during Hypoxia and High-Altitude Pulmonary Edema

2005 ◽  
Vol 171 (1) ◽  
pp. 83-87 ◽  
Author(s):  
Susan R. Hopkins ◽  
Joy Garg ◽  
Divya S. Bolar ◽  
Jamal Balouch ◽  
David L. Levin
Keyword(s):  
Blood Flow ◽  
Pulmonary Edema ◽  
High Altitude ◽  
Pulmonary Blood Flow ◽  
Flow Heterogeneity ◽  
High Altitude Pulmonary Edema ◽  
Blood Flow Heterogeneity

scholarly journals The mechanical and metabolic basis of myocardial blood flow heterogeneity

2001 ◽  
Vol 96 (6) ◽  
pp. 582-594 ◽  
Author(s):  
James B. Bassingthwaighte ◽  
Daniel A. Beard ◽  
Zheng Li
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Flow Heterogeneity ◽  
Metabolic Basis ◽  
Blood Flow Heterogeneity
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