Evidence for dissociation of insulin stimulation of blood flow and glucose uptake in human skeletal muscle: studies using [15O]H2O, [18F]fluoro-2-deoxy-D-glucose, and positron emission tomography

Diabetes ◽  
1996 ◽  
Vol 45 (11) ◽  
pp. 1471-1477 ◽  
Author(s):  
M. Raitakari ◽  
P. Nuutila ◽  
U. Ruotsalainen ◽  
H. Laine ◽  
M. Teras ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Positron Emission Tomography ◽  
Blood Flow ◽  
Glucose Uptake ◽  
Human Skeletal Muscle ◽  
Emission Tomography ◽  
Insulin Stimulation ◽  
Positron Emission ◽  
Stimulation Of

Estimation of blood flow heterogeneity distribution in human skeletal muscle from positron emission tomography data

1997 ◽  
Vol 25 (5) ◽  
pp. 906-910 ◽  
Author(s):  
Paolo Vicini ◽  
Riccardo C. Bonadonna ◽  
Tapio Utriainen ◽  
Pirjo Nuutila ◽  
Maria Raitakari ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Positron Emission Tomography ◽  
Blood Flow ◽  
Human Skeletal Muscle ◽  
Emission Tomography ◽  
Flow Heterogeneity ◽  
Positron Emission ◽  
Heterogeneity Distribution ◽  
Blood Flow Heterogeneity ◽  
Tomography Data

Evaluation of individual skeletal muscle activity by glucose uptake during pedaling exercise at different workloads using positron emission tomography

2009 ◽  
Vol 107 (2) ◽  
pp. 599-604 ◽  
Author(s):  
Yuichi Gondoh ◽  
Manabu Tashiro ◽  
Masatoshi Itoh ◽  
Mohammad M. Masud ◽  
Hiroomi Sensui ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Positron Emission Tomography ◽  
Glucose Uptake ◽  
Muscle Activity ◽  
Rectus Femoris ◽  
Emission Tomography ◽  
Whole Body ◽  
Control Subjects ◽  
Positron Emission ◽  
Iliacus Muscle

Skeletal muscle glucose uptake closely reflects muscle activity at exercise intensity levels <55% of maximal oxygen consumption (V̇o2max). Our purpose was to evaluate individual skeletal muscle activity from glucose uptake in humans during pedaling exercise at different workloads by using [18F]fluorodeoxyglucose (FDG) and positron emission tomography (PET). Twenty healthy male subjects were divided into two groups (7 exercise subjects and 13 control subjects). Exercise subjects were studied during 35 min of pedaling exercise at 40 and 55% V̇o2max exercise intensities. FDG was injected 10 min after the start of exercise or after 20 min of rest. PET scanning of the whole body was conducted after completion of the exercise or rest period. In exercise subjects, mean FDG uptake [standardized uptake ratio (SUR)] of the iliacus muscle and muscles of the anterior part of the thigh was significantly greater than uptake in muscles of control subjects. At 55% V̇o2max exercise, SURs of the iliacus muscle and thigh muscles, except for the rectus femoris, increased significantly compared with SURs at 40% V̇o2max exercise. Our results are the first to clarify that the iliacus muscle, as well as the muscles of the anterior thigh, is the prime muscle used during pedaling exercise. In addition, the iliacus muscle and all muscles in the thigh, except for the rectus femoris, contribute when the workload of the pedaling exercise increases from 40 to 55% V̇o2max.

Assessment of Skeletal Muscle Ventricle Tissue Blood Flow Using Positron Emission Tomography

2001 ◽  
Vol 25 (4) ◽  
pp. 306-312
Author(s):  
Tajinder P. Singh ◽  
Kevin Greer ◽  
Otto Muzik ◽  
Robert L. Hammond ◽  
Larry W. Stephenson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Positron Emission Tomography ◽  
Blood Flow ◽  
Emission Tomography ◽  
Tissue Blood Flow ◽  
Positron Emission

Functional electrical stimulation effect on skeletal muscle blood flow measured with H215O positron emission tomography

1998 ◽  
Vol 79 (6) ◽  
pp. 641-646 ◽  
Author(s):  
Oscar U. Scremin ◽  
Ramon L. Cuevas-Trisan ◽  
A.M.Erika Scremin ◽  
Charles V. Brown ◽  
Mark A. Mandelkern
Keyword(s):  
Skeletal Muscle ◽  
Positron Emission Tomography ◽  
Blood Flow ◽  
Electrical Stimulation ◽  
Functional Electrical Stimulation ◽  
Muscle Blood Flow ◽  
Emission Tomography ◽  
Skeletal Muscle Blood Flow ◽  
Positron Emission

scholarly journals Quantitative Assessment of Glucose Transport in Human Skeletal Muscle: Dynamic Positron Emission Tomography Imaging of [O-Methyl-11C]3-O-Methyl-d-Glucose

2005 ◽  
Vol 90 (3) ◽  
pp. 1752-1759 ◽  
Author(s):  
Alessandra Bertoldo ◽  
Julie Price ◽  
Chet Mathis ◽  
Scott Mason ◽  
Daniel Holt ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Positron Emission Tomography ◽  
Glucose Transport ◽  
Pet Imaging ◽  
Human Skeletal Muscle ◽  
Insulin Infusion ◽  
Emission Tomography ◽  
Dynamic Pet ◽  
Positron Emission ◽  
18F Fdg

Insulin-stimulated glucose transport in skeletal muscle is regarded as a key determinant of insulin sensitivity, yet isolation of this step for quantification in human studies is a methodological challenge. One notable approach is physiological modeling of dynamic positron emission tomography (PET) imaging using 2-[18-fluoro]2-deoxyglucose ([18F]FDG); however, this has a potential limitation in that deoxyglucose undergoes phosphorylation subsequent to transport, complicating separate estimations of these steps. In the current study we explored the use of dynamic PET imaging of [11C]3-O-methylglucose ([11C]3-OMG), a glucose analog that is limited to bidirectional glucose transport. Seventeen lean healthy volunteers with normal insulin sensitivity participated; eight had imaging during basal conditions, and nine had imaging during euglycemic insulin infusion at 30 mU/min·m2. Dynamic PET imaging of calf muscles was conducted for 90 min after the injection of [11C]3-OMG. Spectral analysis of tissue activity indicated that a model configuration of two reversible compartments gave the strongest statistical fit to the kinetic pattern. Accordingly, and consistent with the structure of a model previously used for [18F]FDG, a two-compartment model was applied. Consistent with prior [18F]FDG findings, insulin was found to have minimal effect on the rate constant for movement of [11C]3-OMG from plasma to tissue interstitium. However, during insulin infusion, a robust and highly significant increase was observed in the kinetics of inward glucose transport; this and the estimated tissue distribution volume for [11C]3-OMG increased 6-fold compared with basal conditions. We conclude that dynamic PET imaging of [11C]3-OMG offers a novel quantitative approach that is both chemically specific and tissue specific for in vivo assessment of glucose transport in human skeletal muscle.

scholarly journals Role of blood flow in regulating insulin-stimulated glucose uptake in humans. Studies using bradykinin, [15O]water, and [18F]fluoro-deoxy-glucose and positron emission tomography.

1996 ◽  
Vol 97 (7) ◽  
pp. 1741-1747 ◽  
Author(s):  
P Nuutila ◽  
M Raitakari ◽  
H Laine ◽  
O Kirvelä ◽  
T Takala ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Glucose Uptake ◽  
Emission Tomography ◽  
Positron Emission
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