Studies on suppressor T lymphocyte function in Graves’ disease by3H-thymidine interpolation

1987 ◽  
Vol 7 (1) ◽  
pp. 40-43
Author(s):  
Fang Wei-yi ◽  
Ye Wei-xin
Keyword(s):  
T Lymphocyte ◽  
Graves Disease ◽  
Lymphocyte Function ◽  
Suppressor T Lymphocyte

Suppressor T lymphocyte function in Graves' disease

1982 ◽  
Vol 101 (3) ◽  
pp. 354-358 ◽  
Author(s):  
Bengt Hallengren ◽  
Arne Forsgren
Keyword(s):  
Patient Group ◽  
T Lymphocyte ◽  
Pokeweed Mitogen ◽  
Control Group ◽  
Graves Disease ◽  
Lymphocyte Function ◽  
Euthyroid State ◽  
Hyperthyroid State ◽  
Significant Difference ◽  
Suppressor T Lymphocyte

Abstract. To explore suppressor T lymphocyte function in Graves' disease, studies were performed in one group of patients in the hyperthyroid state and in another group in the euthyroid state after treatment. Peripheral blood lymphocytes were cultured for 1–7 days., Pokeweed mitogen (PWM; 1.25 μg/ml) was added at the initiation of the cultures or after 24 h. The degree of lymphocyte activation was assessed by measurements of the cellular uptake of [3H]thymidine and expressed in counts per minute (cpm). The suppressor lymphocyte function was estimated by a quotient between the maximum cpm values from cultures with and without pre-incubation. For the hyperthyroid group (n = 15) the quotient was 1.00 ± 0.07 (mean ± sem), for the euthyroid patient group (n = 21) 1.12 ± 0.05 and for the healthy control group (n = 21) 1.37 ± 0.08. There was a significant difference between the quotients for the control group and the hyperthyroid (P < 0.01) as well as the euthyroid (P < 0.05) patient group. The quotients for the two groups of patients did not differ significantly. In conclusion, the present study supports the view of a defect in suppressor T lymphocyte function in patients with Graves' disease in the hyperthyroid state and indicates that this defect can persist in the euthyroid state after treatment.

scholarly journals Increased thymic hormone responsive suppressor T lymphocyte function in chronic active hepatitis

1983 ◽  
Vol 28 (4) ◽  
pp. 328-334 ◽  
Author(s):  
Milton G. Mutchnick ◽  
John A. Schaffner ◽  
Jorge A. Prieto ◽  
Frederick E. Weller ◽  
Allan L. Goldstein
Keyword(s):  
T Lymphocyte ◽  
Chronic Active Hepatitis ◽  
Lymphocyte Function ◽  
Thymic Hormone ◽  
Suppressor T Lymphocyte

Preserved Short-Living Suppressor T Lymphocyte Function in Lichen planus

Dermatology ◽  
1987 ◽  
Vol 175 (1) ◽  
pp. 47-48 ◽  
Author(s):  
M. Simon ◽  
J., Jr. Hunyadi ◽  
O.P. Hornstein
Keyword(s):  
Lichen Planus ◽  
T Lymphocyte ◽  
Lymphocyte Function ◽  
Suppressor T Lymphocyte

scholarly journals Suppressor T lymphocyte function in patients with idiopathic congestive cardiomyopathy.

Heart ◽  
1987 ◽  
Vol 57 (5) ◽  
pp. 458-461 ◽  
Author(s):  
P J Lowry ◽  
M D Gammage ◽  
T A Gentle ◽  
M I Baynham ◽  
R A Thompson ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Function ◽  
Congestive Cardiomyopathy ◽  
Suppressor T Lymphocyte
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