Evidence for Cell-Mediated Immunity and Specific Suppressor T Lymphocyte Dysfunction in Graves’ Disease and Diabetes Mellitus*

Abstract. To explore suppressor T lymphocyte function in Graves' disease, studies were performed in one group of patients in the hyperthyroid state and in another group in the euthyroid state after treatment. Peripheral blood lymphocytes were cultured for 1–7 days., Pokeweed mitogen (PWM; 1.25 μg/ml) was added at the initiation of the cultures or after 24 h. The degree of lymphocyte activation was assessed by measurements of the cellular uptake of [3H]thymidine and expressed in counts per minute (cpm). The suppressor lymphocyte function was estimated by a quotient between the maximum cpm values from cultures with and without pre-incubation. For the hyperthyroid group (n = 15) the quotient was 1.00 ± 0.07 (mean ± sem), for the euthyroid patient group (n = 21) 1.12 ± 0.05 and for the healthy control group (n = 21) 1.37 ± 0.08. There was a significant difference between the quotients for the control group and the hyperthyroid (P < 0.01) as well as the euthyroid (P < 0.05) patient group. The quotients for the two groups of patients did not differ significantly. In conclusion, the present study supports the view of a defect in suppressor T lymphocyte function in patients with Graves' disease in the hyperthyroid state and indicates that this defect can persist in the euthyroid state after treatment.

Download Full-text

Studies on suppressor T lymphocyte function in Graves’ disease by3H-thymidine interpolation

Journal of Tongji Medical University ◽

10.1007/bf02888142 ◽

1987 ◽

Vol 7 (1) ◽

pp. 40-43

Author(s):

Fang Wei-yi ◽

Ye Wei-xin

Keyword(s):

T Lymphocyte ◽

Graves Disease ◽

Lymphocyte Function ◽

Suppressor T Lymphocyte

Download Full-text

Suppressor T-Lymphocyte Deficiency in Graves’ Disease and Hashimoto’s Thyroiditis*

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem-52-3-528 ◽

1981 ◽

Vol 52 (3) ◽

pp. 528-533 ◽

Cited By ~ 60

Author(s):

NOBUMITSU OKITA ◽

VAS V. ROW ◽

ROBERT VOLPÉ

Keyword(s):

T Lymphocyte ◽

Hashimoto’S Thyroiditis ◽

Hashimoto's Thyroiditis ◽

Graves Disease ◽

Suppressor T Lymphocyte

Download Full-text

Suppressor T Lymphocyte Dysfunction in Graves' Disease: Role of the H-2 Histamine Receptor-Bearing Suppressor T Lymphocytes*

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem-53-5-1002 ◽

1981 ◽

Vol 53 (5) ◽

pp. 1002-1007 ◽

Cited By ~ 21

Author(s):

NOBUMITSU OKITA ◽

JACQUES HOW ◽

DUNCAN TOPLISS ◽

MARK LEWIS ◽

VAS V. ROW ◽

...

Keyword(s):

T Lymphocytes ◽

T Lymphocyte ◽

Histamine Receptor ◽

Graves Disease ◽

Suppressor T Lymphocytes ◽

Suppressor T Lymphocyte

Download Full-text

T Lymphocyte Polyclonal Proliferation and Stress Response Style

Psychological Reports ◽

10.1177/0033294187060003-221.1 ◽

1987 ◽

Vol 60 (3_part_2) ◽

pp. 1121-1122

Author(s):

Edward A. Workman ◽

Mariano F. La Via

Keyword(s):

T Cell ◽

T Lymphocyte ◽

Life Stress ◽

Type A Behavior ◽

Response Style ◽

Cell Mediated Immunity ◽

Behavioral Indices ◽

Cell Immunity ◽

Stress Avoidance ◽

Pearson Correlations

18 subjects were measured on cell-mediated immunity (T lymphocyte polyclonal proliferation) and four behavioral indices including over-all life stress, stress-avoidance tendency, stress-intrusion tendency, and tendency toward cardiovascular Type A behavior. Of Pearson correlations computed between T lymphocyte polyclonal proliferation and each of the four behavioral indices, the only significant value was that, .47, between T cell immunity and tendency toward stress avoidance. Of the variables investigated, the best predictor of T cell immunocompetence is the tendency toward avoiding stress. Results are discussed in terms of implications for research.

Download Full-text