Clinical importance of technetium-99m-methoxyisobutylisonitrile (MIBI) scintigraphy in differentiated thyroid carcinoma patients with elevated thyroglobulin levels and negative I-131 scanning results

2006 ◽  
Vol 20 (6) ◽  
pp. 393-397 ◽  
Author(s):  
Nuriye Özlem KüÇük ◽  
Hülya Atalay Kulak ◽  
Gülseren Aras
Keyword(s):  
Thyroid Carcinoma ◽  
Clinical Importance ◽  
Differentiated Thyroid Carcinoma ◽  
Technetium 99M ◽  
Technetium 99M Methoxyisobutylisonitrile ◽  
Mibi Scintigraphy

Technetium-99m tetrofosmin and technetium-99m sestamibi imaging of multiple metastases from differentiated thyroid carcinoma

1995 ◽  
Vol 22 (10) ◽  
pp. 1218-1220 ◽  
Author(s):  
Shigeru Kosuda ◽  
Hisaaki Yokoyama ◽  
Michiaki Katayama ◽  
Tokuzo Yokokawa ◽  
Shoichi Kusano ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Technetium 99M Sestamibi ◽  
Technetium 99M ◽  
Technetium 99M Tetrofosmin ◽  
Sestamibi Imaging ◽  
Multiple Metastases

Usefulness of technetium-99m hydroxymethylene diphosphonate scans in localizing bone metastases of differentiated thyroid carcinoma

1993 ◽  
Vol 20 (12) ◽  
Author(s):  
F. Tenenbaum ◽  
M. Schlumberger ◽  
F. Bonnin ◽  
J. Lumbroso ◽  
B. Aubert ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Bone Metastases ◽  
Differentiated Thyroid Carcinoma ◽  
Technetium 99M

Tc99m-MIBI scintigraphy in patients with non-functioning metastases of differentiated thyroid carcinoma (DTC)

1998 ◽  
Vol 52 (7-8) ◽  
pp. 333
Author(s):  
D. Casara ◽  
G. Saladini ◽  
D. Rubello ◽  
G. Tomasella ◽  
M.E. Girelli ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Mibi Scintigraphy

scholarly journals Measuring Thyroglobulin Concentrations in Patients with Differentiated Thyroid Carcinoma

2010 ◽  
Vol 29 (4) ◽  
pp. 243-253 ◽  
Author(s):  
Svetlana Savin ◽  
Dubravka Cvejić ◽  
Ljiljana Mijatović ◽  
Snežana Simonović
Keyword(s):  
Thyroid Carcinoma ◽  
Thyroid Tissue ◽  
Cancer Recurrence ◽  
Clinical Importance ◽  
Differentiated Thyroid Carcinoma ◽  
Antigenic Determinants ◽  
Endocrine Tumors ◽  
Patient Anxiety ◽  
Serum Factors ◽  
Secondary Antibodies

Measuring Thyroglobulin Concentrations in Patients with Differentiated Thyroid CarcinomaThyroid carcinomas are the most common malignant endocrine tumors. Thyroglobulin (Tg), a specific thyroid protein, is the most important tumor marker in thyroid oncology. After total thyroidectomy or radioiodine therapy, detectable or increasing serum Tg levels in patients with differentiated thyroid carcinoma indicate persistence of active thyroid tissue or cancer recurrence. Serum Tg concentration primarily reflects three variables: the mass of differentiated thyroid tissue present; the degree of thyrotropin receptor stimulation and the intrinsic ability of the tumor to synthesize and secrete Tg. Measurement of serum Tg by current immunometric (IMA) and radioimmunological (RIA) assays encounters some methodological problems which can diminish its clinical importance. Discrepancy between the results for Tg using different methods may be caused by: different reference materials, specific properties of the primary and secondary antibodies for antigenic determinants on Tg and diverse binding affinities of these epitopes, together with interference by serum factors (usually antibodies to Tg (TgAb)) with the primary and secondary Tg antibodies from the diagnostic set. In the presence of endogenous TgAb, Tg values measured by immunoradiometric assay (IRMA) and similar assays are usually lower than the real concentrations, while in RIA apparently lower or higher results can be obtained. Falsely low values may lead to delay in necessary treatment, while an inappropriately high Tg value can cause patient anxiety and unnecessary scans. Despite current methodological limitations, serum Tg measurement is a useful test for determining worsening disease and monitoring the effects of therapy in patients who have undergone surgery for differentiated thyroid carcinoma.

Clinical utility of technetium-99m methoxisobutylisonitrile imaging in differentiated thyroid carcinoma: comparison with thallium-201 and iodine-131 Na scintigraphy, and serum thyroglobulin quantitation

1995 ◽  
Vol 22 (11) ◽  
pp. 1330-1338 ◽  
Author(s):  
Simin Dadparvar ◽  
Anita Chevres ◽  
Mark Tulchinsky ◽  
Lalitha Krishna-Badrinath ◽  
Angabeen S. Khan ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Clinical Utility ◽  
Differentiated Thyroid Carcinoma ◽  
Thallium 201 ◽  
Serum Thyroglobulin ◽  
Technetium 99M ◽  
Iodine 131

Clinical importance of anti-thyroglobulin auto-antibodies in patients with differentiated thyroid carcinoma: Comparison with 99mTc-MIBI scans

2006 ◽  
Vol 27 (11) ◽  
pp. 873-876 ◽  
Author(s):  
Ozlem N. K??????k ◽  
G??lseren Aras ◽  
Hulya A. Kulak ◽  
Erkan ??bi??
Keyword(s):  
Thyroid Carcinoma ◽  
Clinical Importance ◽  
Differentiated Thyroid Carcinoma ◽  
99Mtc Mibi

Clinical evaluation of a new thyroglobulin immunoradiometric assay in the follow-up of differentiated thyroid carcinoma

2003 ◽  
Vol 42 (02) ◽  
pp. 71-77 ◽  
Author(s):  
I. Schreivogel ◽  
C. Angerstein ◽  
U. Siefker ◽  
K. Lehmann ◽  
G. Altenvoerde ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Residual Disease ◽  
False Negative ◽  
Differentiated Thyroid Carcinoma ◽  
Threshold Concentration ◽  
High Rate ◽  
Functional Assay ◽  
Hypothyroid Patient ◽  
Assay Sensitivity ◽  
Significant Difference

SummaryAim: Formal and clinical comparison of a new 3rd-gene-ration-Tg-IRMA (3-G-IRMA; Dynotest®Tg-plus) with a conventional Tg-IRMA (3-G-IRMA; SELco®Tg-assay) for patients with differentiated thyroid carcinoma. In addition we evaluated, if thyroglobulin (Tg) levels above a specific threshold concentration indicate the need for further investigations for residual disease. Patients, methods: Tg concentration of 105 sera of 93 consecutive patients with a differentiated thyroid cancer was determined with both assays and compared at different cut-off values (Dynotest®Tg-plus: 0.2, 1, 2 ng/ml; SELco®Tg-assay: 0.5, 1, 2 ng/ml) with the clinical results in respect to the corresponding TSH concentration. Results: Tg concentration did not show any significant difference (SELco®Tg-assay 0.5 ng/ml, Dynotest® Tg-plus 0.2 ng/ml). The Tg-values of both assays correlated with 97%. However, correlation of recovery in both assays was small (40%). The sensitivities and specificities of both assays at different cut-offs and TSH values did not reveal significant differences. In patients with TSH concentration >30 µU/ml the functional assay sensitivity was superior to arbitrary cut-offs in the decision to start further evaluations. Conclusions: In our study neither formal nor clinical significant differences between two Tg-assays were found. In a hypothyroid patient (TSH >30 µU/ml, Tg concentration exceeding the functional assay sensitivity) further investigations for residual disease are warranted. Higher thresholds are of limited value, due to a inacceptable high rate of false negative results.

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