Multiple Oral Dose Pharmacokinetic and Pharmacodynamic Study of a Sustained-Release Formulation of Bunazosin (E1015) in Healthy Volunteers

1993 ◽  
Vol 5 (6) ◽  
pp. 302-308
Author(s):  
Nobumichi Morishita ◽  
Yoshiro Tomono ◽  
Jiro Hasegawa ◽  
Paul Branagan
Keyword(s):  
Oral Dose ◽  
Sustained Release ◽  
Healthy Volunteers ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Multiple Oral Dose ◽  
Pharmacodynamic Study

A Dose Dumping Study with a Sustained-Release Formulation of Bunazosin (E1015) in Healthy Volunteers

1993 ◽  
Vol 6 (1) ◽  
pp. 1-4
Author(s):  
Nobumichi Morishita ◽  
Yoshiro Tomono ◽  
Yves Mainguy ◽  
Paul Branagan ◽  
Maguy Bromet-Petit ◽  
...  
Keyword(s):  
Sustained Release ◽  
Healthy Volunteers ◽  
Release Formulation ◽  
Sustained Release Formulation

Pharmacokinetic Evaluation of a Sustained-release Formulation of Trihexyphenidyl in Healthy Volunteers

1988 ◽  
Vol 77 (9) ◽  
pp. 748-750 ◽  
Author(s):  
Wing K. Cheung ◽  
Steven S. Stravinski ◽  
Steven I. Engel ◽  
Luisa L. Sia ◽  
Avraham Yacobi ◽  
...  
Keyword(s):  
Sustained Release ◽  
Healthy Volunteers ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Pharmacokinetic Evaluation

scholarly journals Sustained-Release Formulation of Doxycycline Hyclate for Prophylaxis of Tick Bite Infection in a Murine Model of Lyme Borreliosis

2004 ◽  
Vol 48 (7) ◽  
pp. 2697-2699 ◽  
Author(s):  
N. S. Zeidner ◽  
K. S. Brandt ◽  
E. Dadey ◽  
M. C. Dolan ◽  
C. Happ ◽  
...  
Keyword(s):  
Oral Dose ◽  
Sustained Release ◽  
Single Oral Dose ◽  
Lyme Borreliosis ◽  
Murine Model ◽  
Single Injection ◽  
Tick Bite ◽  
Doxycycline Hyclate ◽  
Release Formulation ◽  
Sustained Release Formulation

ABSTRACT The prophylactic potential of a single injection of sustained-release doxycycline hyclate (Atridox) was compared to that of a single oral dose of doxycycline hyclate in a murine model of Lyme borreliosis. Prophylaxis, as measured by the lack of cultivable spirochetes and demonstrable pathology, was noted for 43% of orally treated mice; in contrast, the sustained-release doxycycline hyclate completely protected mice from infection and resultant pathology.

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