Human Papillomavirus 16 E6/E7 Transcript and E2 Gene Status in Patients with Cervical Neoplasia

2004 ◽  
Vol 8 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Narayanan Sathish ◽  
Priya Abraham ◽  
Abraham Peedicayil ◽  
Gopalan Sridharan ◽  
Subhashini John ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cervical Neoplasia ◽  
Human Papillomavirus 16 ◽  
E2 Gene ◽  
Gene Status

Impact of viral E2-gene status on outcome after radiotherapy for patients with human papillomavirus 16–positive cancer of the uterine cervix

2006 ◽  
Vol 65 (3) ◽  
pp. 760-765 ◽  
Author(s):  
Katja Lindel ◽  
Ethel-Michele de Villiers ◽  
Philipp Burri ◽  
Ueli Studer ◽  
Hans J. Altermatt ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Uterine Cervix ◽  
Human Papillomavirus 16 ◽  
E2 Gene ◽  
Gene Status

Clinical Significance of Serum Anti-Human Papillomavirus 16 and 18 Antibodies in Cervical Neoplasia

2013 ◽  
Vol 121 (2, PART 1) ◽  
pp. 321-329 ◽  
Author(s):  
Doo Byung Chay ◽  
Hanbyoul Cho ◽  
Bo Wook Kim ◽  
Eun Suk Kang ◽  
Eunseop Song ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Clinical Significance ◽  
Cervical Neoplasia ◽  
Human Papillomavirus 16

Human papillomavirus 16 E6, L1, L2 and E2 gene variants in cervical lesion progression

2008 ◽  
Vol 131 (1) ◽  
pp. 106-110 ◽  
Author(s):  
K. Lee ◽  
I. Magalhaes ◽  
C. Clavel ◽  
J. Briolat ◽  
P. Birembaut ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cervical Lesion ◽  
Gene Variants ◽  
Human Papillomavirus 16 ◽  
E2 Gene

Dominant human papillomavirus 16 infection in cervical neoplasia in young Japanese women; study of 881 outpatients

2004 ◽  
Vol 94 (2) ◽  
pp. 509-514 ◽  
Author(s):  
Nobuo Masumoto ◽  
Takuma Fujii ◽  
Mitsuya Ishikawa ◽  
Makio Mukai ◽  
Akiko Ono ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cervical Neoplasia ◽  
Japanese Women ◽  
Human Papillomavirus 16 ◽  
Young Japanese Women

scholarly journals Enhanced oncogenicity of Asian-American human papillomavirus 16 is associated with impaired E2 repression of E6/E7 oncogene transcription

2004 ◽  
Vol 85 (6) ◽  
pp. 1433-1444 ◽  
Author(s):  
Rosa M. Ordóñez ◽  
Ana María Espinosa ◽  
Dolores Javier Sánchez-González ◽  
Juan Armendáriz-Borunda ◽  
Jaime Berumen
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Asian American ◽  
Long Control Region ◽  
Hpv 16 ◽  
E2 Protein ◽  
Human Papillomavirus 16 ◽  
E2 Gene ◽  
E7 Oncogene

Asian-American (AA) variants of human papillomavirus 16 (HPV-16) are linked to a high incidence of cervical cancer in Mexico, with some evidence strongly suggesting that they are more oncogenic than European (E) variants, including their association with younger women and their higher associated risk of cervical cancer. Differences in the regulation of viral E6/E7 oncogene transcription by the E2 protein may be involved in the higher oncogenicity of AA variants. In E variants, E6/E7 oncogene transcription is repressed by the E2 protein and is frequently up-regulated by the destruction of the E2 gene during viral integration. In contrast, the E2 gene is retained in full in most AA-positive carcinomas, raising the possibility of alternative mechanisms for increasing viral oncogene transcription. The authors investigated whether the higher oncogenicity of AA variants is linked to differences in E6/E7 oncogene transcription and the mechanism of E2 deactivation. E6/E7 and E1/E2 transcripts were explored by RT-PCR in 53 HPV-16-positive cervical carcinomas, 39 retaining (20 European and 19 AA) and 14 having lost (12 European and 2 AA) the E1/E2 genes, and transcription repression activity of the AA E2 genes was tested in four cell lines that constitutively express the β-galactosidase reporter or E6/E7 genes driven by the viral long control region. E6/E7 oncogene transcripts were found in all carcinomas, but only those positive for AA variants with E1/E2 genes had complete E2 transcripts. E2 transcripts were down-regulated by splicing in E-positive carcinomas retaining E1/E2. AA E2 genes were impaired for repression of E6/E7 oncogene transcription in vivo. These results suggest that E6/E7 oncogene expression starts earlier in AA than E variant infections, since E variants need E2 to be destroyed or down-regulated.

scholarly journals Methylation of human papillomavirus 16, 18, 31, and 45 L2 and L1 genes and the cellular DAPK gene: Considerations for use as biomarkers of the progression of cervical neoplasia

Virology ◽  
2014 ◽  
Vol 448 ◽  
pp. 314-321 ◽  
Author(s):  
Mina Kalantari ◽  
Kathryn Osann ◽  
Itzel E. Calleja-Macias ◽  
Seong Kim ◽  
Bing Yan ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cervical Neoplasia ◽  
Human Papillomavirus 16

scholarly journals In vitro Progression of Human Papillomavirus 16 Episome-Associated Cervical Neoplasia Displays Fundamental Similarities to Integrant-Associated Carcinogenesis

2010 ◽  
Vol 70 (10) ◽  
pp. 4081-4091 ◽  
Author(s):  
Elizabeth Gray ◽  
Mark R. Pett ◽  
Dawn Ward ◽  
David M. Winder ◽  
Margaret A. Stanley ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cervical Neoplasia ◽  
Human Papillomavirus 16

scholarly journals Viral Load, E2 Gene Disruption Status, and Lineage of Human Papillomavirus Type 16 Infection in Cervical Neoplasia

2006 ◽  
Vol 194 (12) ◽  
pp. 1706-1712 ◽  
Author(s):  
Jo L. K. Cheung ◽  
Keith W. K. Lo ◽  
Tak‐Hong Cheung ◽  
Julian W. Tang ◽  
Paul K. S. Chan
Keyword(s):  
Human Papillomavirus ◽  
Viral Load ◽  
Gene Disruption ◽  
Cervical Neoplasia ◽  
Human Papillomavirus Type 16 ◽  
E2 Gene
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