Chloroquine challenges quinine for severe falciparum malaria

InPharma ◽  
1989 ◽  
Vol 717 (1) ◽  
pp. 8-8
Keyword(s):  
Falciparum Malaria ◽  
Severe Falciparum Malaria

scholarly journals Identifying prognostic factors of severe metabolic acidosis and uraemia in African children with severe falciparum malaria: a secondary analysis of a randomized trial

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Grace Mzumara ◽  
Stije Leopold ◽  
Kevin Marsh ◽  
Arjen Dondorp ◽  
Eric O. Ohuma ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Metabolic Acidosis ◽  
Falciparum Malaria ◽  
Model Building ◽  
Statistical Significance ◽  
Severe Metabolic Acidosis ◽  
African Countries ◽  
Prognostic Features ◽  
African Children ◽  
Severe Falciparum Malaria

Abstract Background Severe metabolic acidosis and acute kidney injury are major causes of mortality in children with severe malaria but are often underdiagnosed in low resource settings. Methods A retrospective analysis of the ‘Artesunate versus quinine in the treatment of severe falciparum malaria in African children’ (AQUAMAT) trial was conducted to identify clinical features of severe metabolic acidosis and uraemia in 5425 children from nine African countries. Separate models were fitted for uraemia and severe metabolic acidosis. Separate univariable and multivariable logistic regression were performed to identify prognostic factors for severe metabolic acidosis and uraemia. Both analyses adjusted for the trial arm. A forward selection approach was used for model building of the logistic models and a threshold of 5% statistical significance was used for inclusion of variables into the final logistic model. Model performance was assessed through calibration, discrimination, and internal validation with bootstrapping. Results There were 2296 children identified with severe metabolic acidosis and 1110 with uraemia. Prognostic features of severe metabolic acidosis among them were deep breathing (OR: 3.94, CI 2.51–6.2), hypoglycaemia (OR: 5.16, CI 2.74–9.75), coma (OR: 1.72 CI 1.17–2.51), respiratory distress (OR: 1.46, CI 1.02–2.1) and prostration (OR: 1.88 CI 1.35–2.59). Features associated with uraemia were coma (3.18, CI 2.36–4.27), Prostration (OR: 1.78 CI 1.37–2.30), decompensated shock (OR: 1.89, CI 1.31–2.74), black water fever (CI 1.58. CI 1.09–2.27), jaundice (OR: 3.46 CI 2.21–5.43), severe anaemia (OR: 1.77, CI 1.36–2.29) and hypoglycaemia (OR: 2.77, CI 2.22–3.46) Conclusion Clinical and laboratory parameters representing contributors and consequences of severe metabolic acidosis and uraemia were independently associated with these outcomes. The model can be useful for identifying patients at high risk of these complications where laboratory assessments are not routinely available.

scholarly journals Direct In Vivo Assessment of Microcirculatory Dysfunction in Severe Falciparum Malaria

2008 ◽  
Vol 197 (1) ◽  
pp. 79-84 ◽  
Author(s):  
A. M. Dondorp ◽  
C. Ince ◽  
P. Charunwatthana ◽  
J. Hanson ◽  
A. van Kuijen ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Microcirculatory Dysfunction ◽  
Severe Falciparum Malaria ◽  
In Vivo Assessment

scholarly journals Relationship of Cell‐Free Hemoglobin to Impaired Endothelial Nitric Oxide Bioavailability and Perfusion in Severe Falciparum Malaria

2009 ◽  
Vol 200 (10) ◽  
pp. 1522-1529 ◽  
Author(s):  
Tsin W. Yeo ◽  
Daniel A. Lampah ◽  
Emiliana Tjitra ◽  
Retno Gitawati ◽  
Enny Kenangalem ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Falciparum Malaria ◽  
Free Hemoglobin ◽  
Relationship Of ◽  
Endothelial Nitric Oxide ◽  
Severe Falciparum Malaria ◽  
Nitric Oxide Bioavailability

scholarly journals Prophylactic phenobarbitone in young children with severe falciparum malaria: pharmacokinetics and clinical effects.

1992 ◽  
Vol 33 (2) ◽  
pp. 149-154 ◽  
Author(s):  
PA Winstanley ◽  
CR Newton ◽  
G Pasvol ◽  
FJ Kirkham ◽  
E Mberu ◽  
...  
Keyword(s):  
Young Children ◽  
Falciparum Malaria ◽  
Clinical Effects ◽  
Severe Falciparum Malaria

scholarly journals Severe falciparum malaria with hypophosphataemia and presumed hypophosphatemia induced rhabdomyolysis: a case report

2018 ◽  
Vol 8 (2) ◽  
pp. 142
Author(s):  
M Perera ◽  
V Samarawickrama ◽  
K Lokuketagoda ◽  
K Thirumavalawan
Keyword(s):  
Case Report ◽  
Falciparum Malaria ◽  
Severe Falciparum Malaria
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