Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations

2008 ◽  
Vol 31 (11) ◽  
pp. 946-949 ◽  
Author(s):  
R. M. Ruggeri ◽  
L. Santarpia ◽  
L. Curtò ◽  
M. L. Torre ◽  
M. Galatioto ◽  
...  
Keyword(s):  
G Protein ◽  
Pituitary Adenomas ◽  
Protein Gene ◽  
Gene Mutations ◽  
Non Functioning Pituitary Adenomas

Familial isolated pituitary adenoma syndrome

2011 ◽  
Vol 152 (18) ◽  
pp. 722-730 ◽  
Author(s):  
Judit Dénes ◽  
Márta Korbonits ◽  
Erika Hubina ◽  
Gábor László Kovács ◽  
László Kovács ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Aryl Hydrocarbon Receptor ◽  
Pituitary Adenomas ◽  
Protein Gene ◽  
Gene Mutations ◽  
Carney Complex ◽  
Incomplete Penetrance ◽  
Causative Gene ◽  
Interacting Protein ◽  
Aryl Hydrocarbon

Familial pituitary adenomas occur in multiple endocrine neoplasia type 1, Carney complex, as well as in familial isolated pituitary adenoma syndrome. Familial isolated pituitary adenoma syndrome is an autosomal dominant disease with incomplete penetrance. Pituitary adenomas occur in familial setting but without any other specific tumors. In 20-40% of families with this syndrome, mutations have been identified in the aryl hydrocarbon receptor interacting protein gene while in the rest of the families the causative gene or genes have not been identified. Families carrying aryl hydrocarbon receptor interacting protein gene mutations have a distinct phenotype with younger age at diagnosis and a predominance of somatotroph and lactotroph adenomas. Germline mutations of the aryl hydrocarbon receptor interacting protein gene can be occasionally identified in usually young-onset seemingly sporadic cases. Genetic and clinical testing of relatives of patients with aryl hydrocarbon receptor interacting protein gene mutations can lead to earlier diagnosis and treatment at an earlier stage of the pituitary tumor. Orv. Hetil., 2011, 152, 722–730.

G protein gene mutations in patients with multiple endocrinopathies.

1995 ◽  
Vol 80 (5) ◽  
pp. 1702-1705
Author(s):  
E A Williamson ◽  
S J Johnson ◽  
S Foster ◽  
P Kendall-Taylor ◽  
P E Harris
Keyword(s):  
G Protein ◽  
Protein Gene ◽  
Gene Mutations

scholarly journals Diagnosis of G-Protein Gene Mutations in Mc Cune-Albright Syndrome. 15

1998 ◽  
Vol 43 (2) ◽  
pp. 297-297 ◽  
Author(s):  
H M Domene ◽  
M Gryngarten ◽  
G Sanso ◽  
S Copelli ◽  
M E Escobar
Keyword(s):  
G Protein ◽  
Protein Gene ◽  
Gene Mutations ◽  
Albright Syndrome

Genomic instability in non-functioning pituitary adenomas

2005 ◽  
Vol 113 (08) ◽  
Author(s):  
J Szymas ◽  
K Schluens ◽  
W Liebert ◽  
I Petersen
Keyword(s):  
Genomic Instability ◽  
Pituitary Adenomas ◽  
Non Functioning Pituitary Adenomas

AIP expression in non-functioning pituitary adenomas is strongly associated with the gonadotroph phenotype but not with tumour aggressiveness

2014 ◽  
Author(s):  
Sandra Rotondi ◽  
Maria Antonietta Oliva ◽  
Vincenzo Esposito ◽  
Luca Ventura ◽  
Felice Giangaspero ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Non Functioning Pituitary Adenomas
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