Acquisition of Lever Pressing by Rats with and without Magazine Training

1976 ◽  
Vol 26 (3) ◽  
pp. 355-359 ◽  
Author(s):  
Laurence Miller
Keyword(s):  
Magazine Training ◽  
Lever Pressing

Dopamine and the elements of incentive learning

2018 ◽  
Author(s):  
Richard J. Beninger
Keyword(s):  
Dopamine Receptor ◽  
Dopaminergic Neurons ◽  
Lever Press ◽  
Conditioned Avoidance ◽  
Magazine Training ◽  
Warning Stimulus ◽  
Incentive Learning ◽  
Conditioned Activity ◽  
Lever Pressing ◽  
Conditioned Incentive Stimuli

Dopamine and the elements of incentive learning explains how, in lever pressing for food tasks, incentive learning produces a gradient of attractiveness of environment stimuli: during magazine training, food activates dopaminergic neurons and the click and food cup become conditioned incentive stimuli, acquiring the ability to elicit approach and other responses; during lever-press training, the click activates dopaminergic neurons and the lever and lever-related stimuli become conditioned incentive stimuli. In conditioned place preference, amphetamine enhances dopaminergic neurotransmission and stimuli paired with amphetamine become conditioned incentive stimuli. In conditioned activity experiments, test-box stimuli paired with a dopamine-enhancer, e.g., cocaine, produce greater activity revealing incentive learning. In conditioned avoidance, the offset of an aversive warning stimulus putatively activates dopaminergic neurons leading safety-related stimuli to become conditioned incentive stimuli. If trained animals are treated with a dopamine receptor blocker, the initially intact ability of conditioned incentive stimuli to control responding declines over trials.

EFFECTS OF SEVERAL DRUGS ON RELEVANT AND IRRELEVANT BEHAVIOR COMPONENTS IN A LEVER-PRESSING SITUATION

1962 ◽  
Vol 11 (6) ◽  
pp. 307 ◽  
Author(s):  
DALBIR BINDRA
Keyword(s):  
Lever Pressing

scholarly journals Cannabinoid-Induced Conditioned Place Preference, Intravenous Self-Administration, and Behavioral Stimulation Influenced by Ghrelin Receptor Antagonism in Rats

2021 ◽  
Vol 22 (5) ◽  
pp. 2397
Author(s):  
Chrysostomos Charalambous ◽  
Tereza Havlickova ◽  
Marek Lapka ◽  
Nina Puskina ◽  
Romana Šlamberová ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Fixed Ratio ◽  
Place Preference ◽  
Self Administration ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Ghrelin Receptor ◽  
Addiction Therapy ◽  
Significant Efficacy ◽  
Lever Pressing

Cannabis/cannabinoids are widely used for recreational and therapy purposes, but their risks are largely disregarded. However, cannabinoid-associated use disorders and dependence are alarmingly increasing and an effective treatment is lacking. Recently, the growth hormone secretagogue receptor (GHSR1A) antagonism was proposed as a promising mechanism for drug addiction therapy. However, the role of GHS-R1A and its endogenous ligand ghrelin in cannabinoid abuse remains unclear. Therefore, the aim of our study was to investigate whether the GHS-R1A antagonist JMV2959 could reduce the tetrahydrocannabinol (THC)-induced conditioned place preference (CPP) and behavioral stimulation, the WIN55,212-2 intravenous self-administration (IVSA), and the tendency to relapse. Following an ongoing WIN55,212-2 self-administration, JMV2959 3 mg/kg was administered intraperitoneally 20 min before three consequent daily 120-min IVSA sessions under a fixed ratio FR1, which significantly reduced the number of the active lever-pressing, the number of infusions, and the cannabinoid intake. Pretreatment with JMV2959 suggested reduction of the WIN55,212-2-seeking/relapse-like behavior tested in rats on the twelfth day of the forced abstinence period. On the contrary, pretreatment with ghrelin significantly increased the cannabinoid IVSA as well as enhanced the relapse-like behavior. Co-administration of ghrelin with JMV2959 abolished/reduced the significant efficacy of the GHS-R1A antagonist in the cannabinoid IVSA. Pretreatment with JMV2959 significantly and dose-dependently reduced the manifestation of THC-induced CPP. The THC-CPP development was reduced after the simultaneous administration of JMV2959 with THC during conditioning. JMV2959 also significantly reduced the THC-induced behavioral stimulation in the LABORAS cage. Our findings suggest that GHS-R1A importantly participates in the rewarding/reinforcing effects of cannabinoids.

Gamma-butyrolactone's discriminability and effect on low rates of lever pressing by rats: Alone and in combination with d-amphetamine and naloxone

1988 ◽  
Vol 30 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Kenneth D. McIntire ◽  
James Cleary ◽  
Sharon Weinfurter
Keyword(s):  
Lever Pressing

Discrimination with Light Stimuli and a Lever-Pressing Response inMelipona Rufiventris

1972 ◽  
Vol 11 (2) ◽  
pp. 89-93 ◽  
Author(s):  
I. Pessotti
Keyword(s):  
Light Stimuli ◽  
Lever Pressing

Acquisition of lever pressing for cocaine in C57BL/6J mice: effects of prior Pavlovian conditioning

2003 ◽  
Vol 76 (3-4) ◽  
pp. 543-549 ◽  
Author(s):  
W.C. Griffin ◽  
L.D. Middaugh
Keyword(s):  
Pavlovian Conditioning ◽  
Lever Pressing

Effects of Acceleration Forces on Lever Pressing by the White Rat

1959 ◽  
Vol 5 (1) ◽  
pp. 143-147 ◽  
Author(s):  
William F. Oakes ◽  
John H. Hollis
Keyword(s):  
Lever Pressing
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