On physical mapping algorithms: An error-tolerant test for the consecutive ones property

Author(s):  
Wen-Liar Hsu
2003 ◽  
Vol 19 (11) ◽  
pp. 1303-1310 ◽  
Author(s):  
J. Huang ◽  
S. M. Bhandarkar

1996 ◽  
Vol 71 (1-3) ◽  
pp. 23-40 ◽  
Author(s):  
Jonathan E. Atkins ◽  
Martin Middendorf

Genetics ◽  
1999 ◽  
Vol 153 (4) ◽  
pp. 1701-1708 ◽  
Author(s):  
Martin Beye ◽  
Greg J Hunt ◽  
Robert E Page ◽  
M Kim Fondrk ◽  
Lore Grohmann ◽  
...  

Abstract Sex determination in Hymenoptera is controlled by haplo-diploidy in which unfertilized eggs develop into fertile haploid males. A single sex determination locus with several complementary alleles was proposed for Hymenoptera [so-called complementary sex determination (CSD)]. Heterozygotes at the sex determination locus are normal, fertile females, whereas diploid zygotes that are homozygous develop into sterile males. This results in a strong heterozygote advantage, and the sex locus exhibits extreme polymorphism maintained by overdominant selection. We characterized the sex-determining region by genetic linkage and physical mapping analyses. Detailed linkage and physical mapping studies showed that the recombination rate is <44 kb/cM in the sex-determining region. Comparing genetic map distance along the linkage group III in three crosses revealed a large marker gap in the sex-determining region, suggesting that the recombination rate is high. We suggest that a “hotspot” for recombination has resulted here because of selection for combining favorable genotypes, and perhaps as a result of selection against deleterious mutations. The mapping data, based on long-range restriction mapping, suggest that the Q DNA-marker is within 20,000 bp of the sex locus, which should accelerate molecular analyses.


Author(s):  
Ramtin Afshar ◽  
Michael T. Goodrich ◽  
Pedro Matias ◽  
Martha C. Osegueda

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